Patents by Inventor Akiyoshi Hirata

Akiyoshi Hirata has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 9857369
    Abstract: A substrate for biochips which has a high probe loading amounts and a uniform immobilization density, and which further has a high detection sensitivity and a high reproducibility by preventing a non-specific adsorption of proteins, when used as a substrate for biochips for immobilizing probes composed of biologically relevant substances such as proteins and nucleic acids, is disclosed. Amino groups can be bound to the surface of the substrate uniformly, at a high density and stably by covalently immobilizing an amino group-containing polymer on the surface of the substrate. The probe immobilization rate is high and immobilizing density was uniform by immobilizing a probe composed of a biologically relevant substance such as a protein or nucleic acid by utilizing the amino groups. Further, detection sensitivity and reproducibility are high by inhibiting non-specific adsorption of proteins.
    Type: Grant
    Filed: July 22, 2014
    Date of Patent: January 2, 2018
    Assignees: HIPEP LABORATORIES, NIPPON LIGHT METAL COMPANY, LTD.
    Inventors: Kiyoshi Nokihara, Akiyoshi Hirata, Yasuo Oka, Yasushi Takebayashi
  • Publication number: 20140336081
    Abstract: A substrate for biochips which has a high probe loading amounts and a uniform immobilization density, and which further has a high detection sensitivity and a high reproducibility by preventing a non-specific adsorption of proteins, when used as a substrate for biochips for immobilizing probes composed of biologically relevant substances such as proteins and nucleic acids, is disclosed. Amino groups can be bound to the surface of the substrate uniformly, at a high density and stably by covalently immobilizing an amino group-containing polymer on the surface of the substrate. The probe immobilization rate is high and immobilizing density was uniform by immobilizing a probe composed of a biologically relevant substance such as a protein or nucleic acid by utilizing the amino groups. Further, detection sensitivity and reproducibility are high by inhibiting non-specific adsorption of proteins.
    Type: Application
    Filed: July 22, 2014
    Publication date: November 13, 2014
    Applicants: NIPPON LIGHT METAL COMPANY, LTD., HIPEP LABORATORIES
    Inventors: Kiyoshi NOKIHARA, Akiyoshi HIRATA, Yasuo OKA, Yasushi TAKEBAYASHI
  • Patent number: 8822607
    Abstract: A substrate for biochips which has a high probe loading amounts and a uniform immobilization density, and which further has a high detection sensitivity and a high reproducibility by preventing a non-specific adsorption of proteins, when used as a substrate for biochips for immobilizing probes composed of biologically relevant substances such as proteins and nucleic acids, is disclosed. Amino groups can be bound to the surface of the substrate uniformly, at a high density and stably by covalently immobilizing an amino group-containing polymer on the surface of the substrate. The probe immobilization rate is high and immobilizing density was uniform by immobilizing a probe composed of a biologically relevant substance such as a protein or nucleic acid by utilizing the amino groups. Further, detection sensitivity and reproducibility are high by inhibiting non-specific adsorption of proteins.
    Type: Grant
    Filed: June 30, 2009
    Date of Patent: September 2, 2014
    Assignees: Hipep Laboratories, Nippon Light Metal Company, Ltd.
    Inventors: Kiyoshi Nokihara, Akiyoshi Hirata, Yasuo Oka, Yasushi Takebayashi
  • Publication number: 20110152409
    Abstract: A substrate for biochips which has a high probe loading amounts and a uniform immobilization density, and which further has a high detection sensitivity and a high reproducibility by preventing a non-specific adsorption of proteins, when used as a substrate for biochips for immobilizing probes composed of biologically relevant substances such as proteins and nucleic acids, is disclosed. Amino groups can be bound to the surface of the substrate uniformly, at a high density and stably by covalently immobilizing an amino group-containing polymer on the surface of the substrate. The probe immobilization rate is high and immobilizing density was uniform by immobilizing a probe composed of a biologically relevant substance such as a protein or nucleic acid by utilizing the amino groups. Further, detection sensitivity and reproducibility are high by inhibiting non-specific adsorption of proteins.
    Type: Application
    Filed: June 30, 2009
    Publication date: June 23, 2011
    Inventors: Kiyoshi Nokihara, Akiyoshi Hirata, Yasuo Oka, Yasushi Takebayashi
  • Patent number: 5159022
    Abstract: A crystalline block copolymer containing at least a triblock or at least a radial structure and a process for producing the same, wherein at least one block comprising a vinyl aromatic compound having a glass transition temperature (Tg) of not lower than 50.degree. C., at least one block comprising a conjugated diene polymer having a 1,4-trans linkage content, a Tg not higher than 10.degree. C. and crystallinity at 25.degree. C. and in which the crystalline block copolymer optionally which contains the radial structure further comprises a coupling agent. The polymer or the composition containing the same can be utilized for fixing materials of affected portions for medical purposes, protector materials for various sports, films, laminates, toys, artificial flowers, heat-sensitive sensors, coupling devices, insulating materials, framework materials, etc.
    Type: Grant
    Filed: May 21, 1991
    Date of Patent: October 27, 1992
    Assignee: Asahi Kasei Kogyo Kabushiki Kaisha
    Inventors: Takeshi Ikematu, Hideo Morita, Akiyoshi Hirata