Patents by Inventor Akos Jozsef NYERGES

Akos Jozsef NYERGES has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • NEW CLASS OF DNA GYRASE AND/OR TOPOISOMERASE IV INHIBITORS WITH ACTIVITY AGAINST GRAM-POSITIVE AND GRAM-NEGATIVE BACTERIA
    Publication number: 20210323957
    Abstract: The present invention relates to compounds having a structure of general formula (I), processes for their preparation, pharmaceutical compositions containing them as the active ingredient, to their use as medicaments and to their use in the manufacture of medicaments for use in the treatment of bacterial infections in humans and warm-blooded animals.
    Type: Application
    Filed: September 3, 2019
    Publication date: October 21, 2021
    Inventors: Tihomir Tomasic, Nace Zidar, Martina Durcik, Janez Ilas, Anamarija Zega, Cristina Durante Cruz, Päivi Tammela, Csaba Pál, Ákos József Nyerges, Danijel Kikelj, Lucija Peterlin Masic
  • Mutagenizing intracellular nucleic acids
    Patent number: 10669537
    Abstract: A method of in vivo mutagenesis of a preselected target region (PTR) of an intracellular DNA within a cell culture, which PTR comprises at least one sequence of interest (SOI) which is at least 60 nucleobases long, the method comprising: a) providing a pool of partially overlapping single stranded DNA (ssDNA) oligonucleotides which upon alignment form a continuous sequence that is complementary to the SOI, wherein the pool contains a diversity of mutagenizing oligonucleotides covering nucleobase mismatches at every position of said SOI and combination of said nucleobase mismatches, wherein each mutagenizing oligonucleotide is hybridizing with the PTR and comprises at least one mismatching nucleobase up to 20% mismatching nucleobases, compared to the SOI; b) integrating the pool into said intracellular DNA by homologous recombination and inducing in vivo mutagenesis of the intracellular DNA through hybridizing the oligonucleotides to the PTR, thereby producing a cell library comprising a repertoire of variant
    Type: Grant
    Filed: December 13, 2017
    Date of Patent: June 2, 2020
    Assignee: BIOLOGICAL RESEARCH CENTRE
    Inventors: Akos Jozsef Nyerges, Csaba Pal, Balint Csorgo, Balint Kintses
  • MUTAGENIZING INTRACELLULAR NUCLEIC ACIDS
    Publication number: 20200017850
    Abstract: A method of in vivo mutagenesis of a preselected target region (PTR) of an intracellular DNA within a cell culture, which PTR comprises at least one sequence of interest (SOI) which is at least 60 nucleobases long, the method comprising: a) providing a pool of partially overlapping single stranded DNA (ssDNA) oligonucleotides which upon alignment form a continuous sequence that is complementary to the SOI, wherein the pool contains a diversity of mutagenizing oligonucleotides covering nucleobase mismatches at every position of said SOI and combination of said nucleobase mismatches, wherein each mutagenizing oligonucleotide is hybridizing with the PTR and comprises at least one mismatching nucleobase up to 20% mismatching nucleobases, compared to the SOI; b) integrating the pool into said intracellular DNA by homologous recombination and inducing in vivo mutagenesis of the intracellular DNA through hybridizing the oligonucleotides to the PTR, thereby producing a cell library comprising a repertoire of variant
    Type: Application
    Filed: December 13, 2017
    Publication date: January 16, 2020
    Inventors: Akos Jozsef NYERGES, Csaba PAL, Balint CSORGO, Balint KINTSES