Patents by Inventor Akshay Tambe

Akshay Tambe has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Efficient combinatorial bead barcoding
    Patent number: 12286621
    Abstract: Disclosed herein include methods, compositions, and systems for extending particle-associated oligonucleotides. In some embodiments, the methods of extending particle-associated oligonucleotides enable efficient methods of preparing a library of barcoded beads. It is also provided, in some embodiments, hydrogel beads degradable upon application of a chemical stimulus that comprise releasably attached oligonucleotides.
    Type: Grant
    Filed: September 27, 2019
    Date of Patent: April 29, 2025
    Assignee: California Institute of Technology
    Inventors: Eduardo da Veiga Beltrame, Jase Gehring, Akshay Tambe, Lior S. Pachter, Taleen Dilanyan
  • GUIDE RNAS AND USES THEREOF
    Publication number: 20240409923
    Abstract: Provided herein are DNA targeting systems comprising a site-directed modifying polypeptide and a Tumor Necrosis Factor Alpha-induced Protein 3 (TNFAIP3)-specific guide RNA or a Suppressor of Cytokine Signaling 1 (SOCS1)-specific guide RNA, and uses thereof.
    Type: Application
    Filed: April 19, 2024
    Publication date: December 12, 2024
    Inventors: Benjamin G. Gowen, Mary Janatpour, Kory Melton, Akshay Tambe, Spencer Wei
  • ADAR SPECIFIC GUIDE RNAS AND USES THEREOF
    Publication number: 20240327819
    Abstract: Provided herein are DNA targeting systems comprising a site-directed modifying polypeptide an ADAR-specific guide RNAs, and uses thereof.
    Type: Application
    Filed: October 5, 2023
    Publication date: October 3, 2024
    Inventors: Benjamin G. Gowen, Mary Janatpour, Kory Melton, Akshay Tambe, Spencer Wei
  • METHODS AND COMPOSITIONS FOR NUCLEIC ACID-GUIDED NUCLEASE CELL TARGETING SCREEN
    Publication number: 20220033808
    Abstract: Methods and compositions related to a nucleic acid-guided nuclease cell targeting screen are provided. The invention relates to compositions and methods for identifying cell targeting proteins that, when associated with a nucleic acid-guided nuclease (such as Cas9), enables at least the nucleic acid-guided nuclease to be targeted to the surface of a target cell or internalized by a target cell, i.e., a cell targeted by the cell targeting agent.
    Type: Application
    Filed: October 21, 2021
    Publication date: February 3, 2022
    Applicant: Spotlight Therapeutics
    Inventors: Akshay Tambe, Hariharan Jayaram, Steven Strutt
  • EFFICIENT COMBINATORIAL BEAD BARCODING
    Publication number: 20200102556
    Abstract: Disclosed herein include methods, compositions, and systems for extending particle-associated oligonucleotides. In some embodiments, the methods of extending particle-associated oligonucleotides enable efficient methods of preparing a library of barcoded beads. It is also provided, in some embodiments, hydrogel beads degradable upon application of a chemical stimulus that comprise releasably attached oligonucleotides.
    Type: Application
    Filed: September 27, 2019
    Publication date: April 2, 2020
    Inventors: Eduardo da Veiga Beltrame, Jase Gehring, Akshay Tambe, Lior S. Pachter, Taleen Dilanyan