Patents by Inventor AKSHAYA RAVICHANDRAN

AKSHAYA RAVICHANDRAN has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • ENGINEERING THE PRODUCTION OF A CONFORMATIONAL VARIANT OF OCCIDIOFUNGIN THAT HAS ENHANCED INHIBITORY ACTIVITY AGAINST FUNGAL SPECIES
    Publication number: 20220007652
    Abstract: Occidiofungin is a cyclic nonribosomally synthesized antifungal peptide with submicromolar activity. This invention is directed to compositions enriched for particular occidiofungin diastereomers/conformers, methods of making compositions enriched for particular diastereomers/conformers and microorganisms suitable for producing enriched compositions of particular diastereomers/conformers. Methods of treating fungal infections or plants infected by fungi are also provided.
    Type: Application
    Filed: December 7, 2020
    Publication date: January 13, 2022
    Applicants: Mississippi State University, The Texas A&M University System
    Inventors: JAMES LEIF SMITH, AKSHAYA RAVICHANDRAN, SHIEN LU, GANYU GU
  • SYNTHESIS OF NOVEL XYLOSE FREE OCCIDIOFUNGIN ANALOGUES AND METHODS OF USING THEM
    Publication number: 20210169846
    Abstract: The subject invention pertains to methods for producing novel occidiofungin analogues lacking xylose (OF-?xyl analogue). OF-?xyl analogues can contain aldehyde, amine, triazole, or hydrazones. The aldehyde, amine, triazole or hydrazone containing analogues of OF-?xyl can be further modified by substitution with additional functional groups. Various OF-?xyl analogues described herein have reduced inflammation and toxicity and superior pharmacological properties compared to the natural occidiofungins. Accordingly, certain embodiments of the invention provide methods of treating or preventing fungal infections by administering to the subjects in need thereof the OF-?xyl analogues described herein.
    Type: Application
    Filed: April 5, 2019
    Publication date: June 10, 2021
    Inventors: JAMES L. SMITH, MENGXIN GENG, AKSHAYA RAVICHANDRAN, RAVI ORUGUNTY
  • ENGINEERING THE PRODUCTION OF A CONFORMATIONAL VARIANT OF OCCIDIOFUNGIN THAT HAS ENHANCED INHIBITORY ACTIVITY AGAINST FUNGAL SPECIES
    Publication number: 20190270777
    Abstract: Occidiofungin is a cyclic nonribosomally synthesized antifungal peptide with submicromolar activity. This invention is directed to compositions enriched for particular occidiofungin diastereomers/conformers, methods of making compositions enriched for particular diastereomers/conformers and microorganisms suitable for producing enriched compositions of particular diastereomers/conformers. Methods of treating fungal infections or plants infected by fungi are also provided.
    Type: Application
    Filed: May 3, 2019
    Publication date: September 5, 2019
    Applicants: Mississippi State University, The Texas A&M University System
    Inventors: JAMES LEIF SMITH, AKSHAYA RAVICHANDRAN, SHIEN LU, GANYU GU
  • ENGINEERING THE PRODUCTION OF A CONFORMATIONAL VARIANT OF OCCIDIOFUNGIN THAT HAS ENHANCED INHIBITORY ACTIVITY AGAINST FUNGAL SPECIES
    Publication number: 20170247415
    Abstract: Occidiofungin is a cyclic nonribosomally synthesized antifungal peptide with submicromolar activity. This invention is directed to compositions enriched for particular occidiofungin diastereomers/conformers, methods of making compositions enriched for particular diastereomers/conformers and microorganisms suitable for producing enriched compositions of particular diastereomers/conformers. Methods of treating fungal infections or plants infected by fungi are also provided.
    Type: Application
    Filed: February 22, 2017
    Publication date: August 31, 2017
    Applicants: MISSISSIPPI STATE UNIVERSITY, THE TEXAS A&M UNIVERSITY SYSTEM
    Inventors: JAMES LEIF SMITH, AKSHAYA RAVICHANDRAN, SHIEN LU, GANYU GU
  • Engineering the production of a conformational variant of occidiofungin that has enhanced inhibitory activity against fungal species
    Patent number: 9624270
    Abstract: Occidiofungin is a cyclic nonribosomally synthesized antifungal peptide with submicromolar activity. This invention is directed to compositions enriched for particular occidiofungin diastereomers/conformers, methods of making compositions enriched for particular diastereomers/conformers and microorganisms suitable for producing enriched compositions of particular diastereomers/conformers. Methods of treating fungal infections or plants infected by fungi are also provided.
    Type: Grant
    Filed: November 26, 2013
    Date of Patent: April 18, 2017
    Assignees: MISSISSIPPI STATE UNIVERSITY, THE TEXAS A&M UNIVERSITY SYSTEM
    Inventors: James Leif Smith, Akshaya Ravichandran, Shien Lu, Ganyu Gu
  • ENGINEERING THE PRODUCTION OF A CONFORMATIONAL VARIANT OF OCCIDIOFUNGIN THAT HAS ENHANCED INHIBITORY ACTIVITY AGAINST FUNGAL SPECIES
    Publication number: 20140147416
    Abstract: Occidiofungin is a cyclic nonribosomally synthesized antifungal peptide with submicromolar activity. This invention is directed to compositions enriched for particular occidiofungin diastereomers/conformers, methods of making compositions enriched for particular diastereomers/conformers and microorganisms suitable for producing enriched compositions of particular diastereomers/conformers. Methods of treating fungal infections or plants infected by fungi are also provided.
    Type: Application
    Filed: November 26, 2013
    Publication date: May 29, 2014
    Inventors: JAMES LEIF SMITH, AKSHAYA RAVICHANDRAN, SHIEN LU, GANYU GU