Patents by Inventor Aladar A. Szalay

Aladar A. Szalay has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Smallpox vaccine for cancer treatment
    Patent number: 10076569
    Abstract: Disclosed herein are methods and compositions related to therapy for cancer. More specifically, the disclosed methods and compositions are related to the use of smallpox vaccine to induce an effective anti-tumor immune response.
    Type: Grant
    Filed: August 11, 2016
    Date of Patent: September 18, 2018
    Assignee: Calidi Biotherapeutics, Inc.
    Inventors: Aladar Szalay, Boris Minev
  • MODIFIED VACCINIA VIRUS STRAINS FOR USE IN DIAGNOSTIC AND THERAPEUTIC METHODS
    Publication number: 20180195050
    Abstract: Modified viruses and methods for preparing the modified viruses are provided. Vaccines that contain the viruses are provided. The viruses can be used in methods of treatment of diseases, such as proliferative and inflammatory disorders, including cancer, and as anti-tumor and/or antiangiogenic agents. The viruses also can be used in diagnostic methods.
    Type: Application
    Filed: March 2, 2018
    Publication date: July 12, 2018
    Inventors: Aladar A. SZALAY, Alexa Frentzen, Yong A. Yu, Nanhai Chen, Qian Zhang
  • Modified vaccinia virus strains for use in diagnostic and therapeutic methods
    Patent number: 9944903
    Abstract: Modified viruses and methods for preparing the modified viruses are provided. Vaccines that contain the viruses are provided. The viruses can be used in methods of treatment of diseases, such as proliferative and inflammatory disorders, including cancer, and as anti-tumor and/or antiangiogenic agents. The viruses also can be used in diagnostic methods.
    Type: Grant
    Filed: March 4, 2015
    Date of Patent: April 17, 2018
    Assignee: Genelux Corporation
    Inventors: Aladar A. Szalay, Alexa Frentzen, Yong A. Yu, Nanhai Chen, Qian Zhang
  • VIROTHERAPY WITH AN ANTIBODY COMBINATION
    Publication number: 20180092951
    Abstract: Disclosed herein are viruses that can be used in methods of treatment for cancer. More specifically, the viruses express two or more antibodies which induce an effective anti-tumor immune response. The viruses also can be used in diagnostic methods.
    Type: Application
    Filed: March 17, 2016
    Publication date: April 5, 2018
    Applicant: StemImmune, Incorporated
    Inventors: Aladar SZALAY, Boris MINEV
  • COMBINATION IMMUNOTHERAPY APPROACH FOR TREATMENT OF CANCER
    Publication number: 20170239338
    Abstract: Disclosed herein are methods and compositions related to combination therapy for cancer. More specifically, several treatment modalities are used in combination to induce an effective anti-tumor immune response. The present invention relates generally to the treatment of human cancer and, more specifically, to use of several treatment modalities in combination to induce effective anti-tumor immune responses.
    Type: Application
    Filed: October 23, 2015
    Publication date: August 24, 2017
    Applicant: StemImmune, Incorporated
    Inventors: Aladar SZALAY, Boris MINEV
  • MICROORGANISMS FOR THERAPY
    Publication number: 20170095552
    Abstract: Therapeutic methods and vaccinia virus therefor are provided. The viruses are designed so that they accumulate in immunoprivileged tissues and cells, such as in tumors and other proliferating tissue and in inflamed tissues, compared to other tissues, cells and organs, so that they exhibit relatively low toxicity to host organisms. Combinations of the viruses and anti-cancer agents and uses thereof for treating cancer also are provided.
    Type: Application
    Filed: October 21, 2016
    Publication date: April 6, 2017
    Inventors: Aladar A. SZALAY, Tatyana Timiryasova, Yong A. Yu, Qian Zhang
  • SMALLPOX VACCINE FOR CANCER TREATMENT
    Publication number: 20170043010
    Abstract: Disclosed herein are methods and compositions related to therapy for cancer. More specifically, the disclosed methods and compositions are related to the use of smallpox vaccine to induce an effective anti-tumor immune response.
    Type: Application
    Filed: August 11, 2016
    Publication date: February 16, 2017
    Applicant: StemImmune, Incorporated
    Inventors: Aladar Szalay, Boris Minev
  • ONCOLYTIC VIRUS ADJUNCT THERAPY WITH AGENTS THAT INCREASE VIRUS INFECTIVITY
    Publication number: 20160339066
    Abstract: Provided are adjunct therapies for use in combinations and compositions with an oncolytic virus, such as a vaccinia virus. The adjunct therapies include co-administration and co-formulation of a complement inhibitor and/or a lipid emulsion composition with the oncolytic virus. Also provided herein are therapeutic methods using the adjunct therapies for treatment of disease and conditions employing an oncolytic therapeutic virus, such as for the treatment of hyperproliferative diseases or conditions including tumors or cancers.
    Type: Application
    Filed: December 31, 2014
    Publication date: November 24, 2016
    Inventors: Aladar A. SZALAY, Joseph CAPPELLO, Nanhai G. CHEN, Boris MINEV
  • Microorganisms for therapy
    Patent number: 9492534
    Abstract: Therapeutic methods and vaccinia virus therefor are provided. The viruses are designed so that they accumulate in immunoprivileged tissues and cells, such as in tumors and other proliferating tissue and in inflamed tissues, compared to other tissues, cells and organs, so that they exhibit relatively low toxicity to host organisms. Combinations of the viruses and anti-cancer agents and uses thereof for treating cancer also are provided.
    Type: Grant
    Filed: June 11, 2014
    Date of Patent: November 15, 2016
    Assignee: Genelux Corporation
    Inventors: Aladar A. Szalay, Tatyana Timiryasova, Yong A. Yu, Qian Zhang
  • MODIFIED VACCINIA VIRUS STRAINS FOR USE IN DIAGNOSTIC AND THERAPEUTIC METHODS
    Publication number: 20150175976
    Abstract: Modified viruses and methods for preparing the modified viruses are provided. Vaccines that contain the viruses are provided. The viruses can be used in methods of treatment of diseases, such as proliferative and inflammatory disorders, including cancer, and as anti-tumor and/or antiangiogenic agents. The viruses also can be used in diagnostic methods.
    Type: Application
    Filed: March 4, 2015
    Publication date: June 25, 2015
    Inventors: Aladar A. Szalay, Alexa Frentzen, Yong A. Yu, Nanhai Chen, Qian Zhang
  • Modified vaccinia virus strains for use in diagnostic and therapeutic methods
    Patent number: 9005602
    Abstract: Modified viruses and methods for preparing the modified viruses are provided. Vaccines that contain the viruses are provided. The viruses can be used in methods of treatment of diseases, such as proliferative and inflammatory disorders, including cancer, and as anti-tumor and/or antiangiogenic agents. The viruses also can be used in diagnostic methods.
    Type: Grant
    Filed: August 2, 2011
    Date of Patent: April 14, 2015
    Assignee: Genelux Corporation
    Inventors: Aladar A. Szalay, Yong A. Yu, Nanhai Chen, Qian Zhang
  • METHOD FOR DETECTING REPLICATION OR COLONIZATION OF A BIOLOGICAL THERAPEUTIC
    Publication number: 20150024403
    Abstract: Methods for detecting replication in or colonization of a host by a biological therapeutic, such as an oncolytic virus, cells administered for cell therapy and gene therapy vectors, are provided. In the methods, a product produced by the biological therapeutic is detected in a sample of tissue or body fluid distinct from the administered therapy or locus thereof, thereby permitting assessment of the therapy and/or monitoring its progress.
    Type: Application
    Filed: September 30, 2014
    Publication date: January 22, 2015
    Inventors: Aladar A. SZALAY, Jochen Stritzker, Michael Hess
  • Microorganisms for imaging and/or treatment of tumors
    Patent number: 8865153
    Abstract: Modified viruses encoding transporter proteins and methods for preparing the modified viruses are provided. Vaccines that contain the viruses are provided. The viruses also can be used in diagnostic methods, such detection and imaging of tumors. The viruses also can be used in methods of treatment of diseases, such as proliferative and inflammatory disorders, including as anti-tumor agents.
    Type: Grant
    Filed: May 10, 2012
    Date of Patent: October 21, 2014
    Assignee: Genelux Corporation
    Inventors: Aladar A. Szalay, Nanhai Chen, Yong A. Yu, Qian Zhang
  • Method for detecting replication or colonization of a biological therapeutic
    Patent number: 8859256
    Abstract: Methods for detecting replication in or colonization of a host by a biological therapeutic, such as an oncolytic virus, cells administered for cell therapy and gene therapy vectors, are provided. In the methods, a product produced by the biological therapeutic is detected in a sample of tissue or body fluid distinct from the administered therapy or locus thereof, thereby permitting assessment of the therapy and/or monitoring its progress.
    Type: Grant
    Filed: October 5, 2012
    Date of Patent: October 14, 2014
    Assignee: Genelux Corporation
    Inventors: Aladar A. Szalay, Jochen Stritzker, Michael Hess
  • Microorganisms for imaging and/or treatment of tumors
    Patent number: 8852927
    Abstract: Modified viruses encoding transporter proteins and methods for preparing the modified viruses are provided. Vaccines that contain the viruses are provided. The viruses also can be used in diagnostic methods, such detection and imaging of tumors. The viruses also can be used in methods of treatment of diseases, such as proliferative and inflammatory disorders, including as anti-tumor agents.
    Type: Grant
    Filed: February 23, 2010
    Date of Patent: October 7, 2014
    Assignee: Genelux Corporation
    Inventors: Aladar A. Szalay, Nanhai Chen, Yong A. Yu, Qian Zhang
  • MICROORGANISMS FOR THERAPY
    Publication number: 20140294891
    Abstract: Therapeutic methods and vaccinia virus therefor are provided. The viruses are designed so that they accumulate in immunoprivileged tissues and cells, such as in tumors and other proliferating tissue and in inflamed tissues, compared to other tissues, cells and organs, so that they exhibit relatively low toxicity to host organisms.
    Type: Application
    Filed: June 11, 2014
    Publication date: October 2, 2014
    Inventors: Aladar A. Szalay, Tatyana Timiryasova, Yong A. Yu, Qian Zhang
  • Use of Antibiotics to Enhance Treatment With Therapeutic Viruses
    Publication number: 20140271549
    Abstract: Provided are methods for increasing the therapeutic efficacy of viral therapy by administering an antibiotic effective against commensal bacteria with the viral therapy. Included are methods for treating cancers, tumors and metastases by administering the virus and the antibiotic.
    Type: Application
    Filed: March 11, 2014
    Publication date: September 18, 2014
    Inventor: Aladar A. Szalay
  • Microorganisms for therapy
    Patent number: 8784836
    Abstract: Therapeutic methods and vaccinia virus therefor are provided. The viruses are designed so that they accumulate in immunoprivileged tissues and cells, such as in tumors and other proliferating tissue and in inflamed tissues, compared to other tissues, cells and organs, so that they exhibit relatively low toxicity to host organisms. Combinations of the viruses and anti-cancer agents and uses thereof for treating cancer also are provided.
    Type: Grant
    Filed: July 10, 2012
    Date of Patent: July 22, 2014
    Assignee: Genelux Corporation
    Inventors: Aladar A. Szalay, Tatyana Timiryasova, Yong A. Yu, Qian Zhang
  • Energy Absorbing-Based Diagnostic and Therapeutic Methods Employing Nucleic Acid Molecules Encoding Chromophore-Producing Enzymes
    Publication number: 20140140959
    Abstract: Provided are diagnostic and therapeutic methods using a composition containing a nucleic acid encoding a chromophore-producing enzyme(s), such as a melanin-producing enzyme or enzymes. The nucleic acid molecules can be used for directed or localized delivery to tumors or other cells associated with disease resulting in production of a chromophore product that can be used for diagnosis and therapy, including of tumors and metastases.
    Type: Application
    Filed: October 4, 2013
    Publication date: May 22, 2014
    Inventors: Aladar A. Szalay, Jochen Stritzker
  • Methods for assessing effectiveness and monitoring oncolytic virus treatment
    Publication number: 20140087362
    Abstract: Diagnostic methods for in vivo and ex vivo detection of circulating tumor cells (CTCs) for the diagnosis and treatment of cancer are provided. The diagnostic methods employ oncolytic viruses alone or in combination with one or more tumor cell enrichment and/or detection methods. Combinations and kits for use in the practicing the methods also are provided.
    Type: Application
    Filed: March 13, 2013
    Publication date: March 27, 2014
    Inventors: Aladar A. Szalay, Nanhai G. Chen, Huiqiang Wang, Melody Fells, Albert Roeder, Qian Zhang, Boris Minev