Patents by Inventor Aladar Szalay

Aladar Szalay has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • SMALLPOX VACCINE FOR CANCER TREATMENT
    Publication number: 20230173062
    Abstract: Disclosed herein are methods and compositions related to therapy for cancer. More specifically, the disclosed methods and compositions are related to the use of smallpox vaccine to induce an effective anti-tumor immune response.
    Type: Application
    Filed: January 30, 2023
    Publication date: June 8, 2023
    Inventors: Aladar SZALAY, Boris Minev
  • Smallpox vaccine for cancer treatment
    Patent number: 11607450
    Abstract: Disclosed herein are methods and compositions related to therapy for cancer. More specifically, the disclosed methods and compositions are related to the use of smallpox vaccine to induce an effective anti-tumor immune response.
    Type: Grant
    Filed: November 4, 2020
    Date of Patent: March 21, 2023
    Assignee: Calidi Biotherapeutics, Inc.
    Inventors: Aladar Szalay, Boris Minev
  • VACCINIA VIRAL POLYMERASE-MEDIATED VIRAL REPLICATION
    Publication number: 20230040081
    Abstract: Methods and compositions for regulating activity of a poxvirus viral polymerase by modulating the assembly and/or interaction of one or more subunits of the viral polymerase are described.
    Type: Application
    Filed: December 11, 2020
    Publication date: February 9, 2023
    Inventor: Aladar A. SZALAY
  • CELL-BASED VEHICLES FOR POTENTIATION OF VIRAL THERAPY
    Publication number: 20230022205
    Abstract: Provided herein are carrier cells and virus combinations and methods for treatment of cancers. Also provided are modified carrier cells for such treatment, and methods of selecting carrier cells that are matched to subjects for such treatment.
    Type: Application
    Filed: September 26, 2022
    Publication date: January 26, 2023
    Inventors: Dobrin DRAGANOV, Aladar A. Szalay
  • CLONAL STRAINS OF ATTENUATED VACCINIA VIRUSES AND METHODS OF USE THEREOF
    Publication number: 20230008052
    Abstract: Clonal strains of vaccinia viruses are provided. Also provided are methods of identifying and isolating attenuated and oncolytic clonal strains from virus preparations. Modified recombinant forms of the clonal strains also are provided. The clonal strains and virus preparations can be used for diagnostic and therapeutic methods, in particular for therapy and diagnosis or monitoring treatment of proliferative disorders, including neoplastic diseases, such as, but are not limited to, solid tumors and blood cancers.
    Type: Application
    Filed: September 3, 2021
    Publication date: January 12, 2023
    Inventors: Aladar A. SZALAY, Nanhai G. Chen, Yong A. Yu, Qian Zhang
  • Cell-based vehicles for potentiation of viral therapy
    Patent number: 11505782
    Abstract: Provided herein are carrier cells and virus combinations and methods for treatment of cancers. Also provided are modified carrier cells for such treatment, and methods of selecting carrier cells that are matched to subjects for such treatment.
    Type: Grant
    Filed: August 8, 2019
    Date of Patent: November 22, 2022
    Assignee: Calidi Biotherapeutics, Inc.
    Inventors: Dobrin Draganov, Aladar A. Szalay
  • COMBINATION IMMUNOTHERAPY APPROACH FOR TREATMENT OF CANCER
    Publication number: 20220241388
    Abstract: Disclosed herein are methods and compositions related to combination therapy for cancer. More specifically, several treatment modalities are used in combination to induce an effective anti-tumor immune response.
    Type: Application
    Filed: March 8, 2022
    Publication date: August 4, 2022
    Inventors: Aladar SZALAY, Boris MINEV
  • USE OF POXVIRUS WITH AUTOLOGOUS INDUCED PLURIPOTENT STEM CELLS FOR VACCINATION AND DISEASE THERAPY
    Publication number: 20220228128
    Abstract: Provided herein are compositions of induced pluripotent stem cells (iPSCs), or pancreatic beta cells, and poxvirus, and methods of making and using the same to treat disease.
    Type: Application
    Filed: May 29, 2020
    Publication date: July 21, 2022
    Inventor: Aladar SZALAY
  • SMALLPOX VACCINE AND STEM CELLS FOR TREATMENT OF DISEASE
    Publication number: 20220218818
    Abstract: Described herein are methods and compositions for treating an inflammatory disease or infectious disease in a subject in need thereof by administering to the subject a poxvirus and a stem cell, wherein the disease is not a cancer. The disease may be, for example, a chronic inflammatory disease (e.g., an autoimmune disease).
    Type: Application
    Filed: June 2, 2020
    Publication date: July 14, 2022
    Inventor: Aladar SZALAY
  • Combination immunotherapy approach for treatment of cancer
    Patent number: 11285194
    Abstract: Disclosed herein are methods and compositions related to combination therapy for cancer. More specifically, several treatment modalities are used in combination to induce an effective anti-tumor immune response. The present invention relates generally to the treatment of human cancer and, more specifically, to use of several treatment modalities in combination to induce effective anti-tumor immune responses.
    Type: Grant
    Filed: October 23, 2015
    Date of Patent: March 29, 2022
    Assignee: Calidi Biotherapeutics, Inc.
    Inventors: Aladar Szalay, Boris Minev
  • Clonal strains of attenuated vaccinia viruses and methods of use thereof
    Patent number: 11149254
    Abstract: Clonal strains of vaccinia viruses are provided. Also provided are methods of identifying and isolating attenuated and oncolytic clonal strains from virus preparations. Modified recombinant forms of the clonal strains also are provided. The clonal strains and virus preparations can be used for diagnostic and therapeutic methods, in particular for therapy and diagnosis or monitoring treatment of proliferative disorders, including neoplastic diseases, such as, but are not limited to, solid tumors and blood cancers.
    Type: Grant
    Filed: April 13, 2012
    Date of Patent: October 19, 2021
    Assignee: Genelux Corporation
    Inventors: Aladar A. Szalay, Nanhai G. Chen, Yong A. Yu, Qian Zhang
  • SMALLPOX VACCINE FOR CANCER TREATMENT
    Publication number: 20210046178
    Abstract: Disclosed herein are methods and compositions related to therapy for cancer. More specifically, the disclosed methods and compositions are related to the use of smallpox vaccine to induce an effective anti-tumor immune response.
    Type: Application
    Filed: November 4, 2020
    Publication date: February 18, 2021
    Inventors: Aladar Szalay, Boris Minev
  • Smallpox vaccine for cancer treatment
    Patent number: 10857225
    Abstract: Disclosed herein are methods and compositions related to therapy for cancer. More specifically, the disclosed methods and compositions are related to the use of smallpox vaccine to induce an effective anti-tumor immune response.
    Type: Grant
    Filed: July 24, 2018
    Date of Patent: December 8, 2020
    Assignee: Calidi Biotherapeutics, Inc.
    Inventors: Aladar Szalay, Boris Minev
  • CELL-BASED VEHICLES FOR POTENTIATION OF VIRAL THERAPY
    Publication number: 20200318073
    Abstract: Provided herein are carrier cells and virus combinations and methods for treatment of cancers. Also provided are modified carrier cells for such treatment, and methods of selecting carrier cells that are matched to subjects for such treatment.
    Type: Application
    Filed: August 8, 2019
    Publication date: October 8, 2020
    Inventors: Dobrin Draganov, Aladar A. Szalay
  • Modified vaccinia virus strains for use in diagnostic and therapeutic methods
    Patent number: 10584317
    Abstract: Modified viruses and methods for preparing the modified viruses are provided. Vaccines that contain the viruses are provided. The viruses can be used in methods of treatment of diseases, such as proliferative and inflammatory disorders, including cancer, and as anti-tumor and/or antiangiogenic agents. The viruses also can be used in diagnostic methods.
    Type: Grant
    Filed: March 2, 2018
    Date of Patent: March 10, 2020
    Assignee: Genelux Corporation
    Inventors: Aladar A. Szalay, Alexa Frentzen, Yong A. Yu, Nanhai Chen, Qian Zhang
  • CELL-BASED VEHICLES FOR POTENTIATION OF VIRAL THERAPY
    Publication number: 20190367880
    Abstract: Provided herein are carrier cells and virus combinations and methods for treatment of cancers. Also provided are modified carrier cells for such treatment, and methods of selecting carrier cells that are matched to subjects for such treatment.
    Type: Application
    Filed: August 8, 2019
    Publication date: December 5, 2019
    Inventors: Dobrin Draganov, Aladar A. Szalay
  • Microorganisms for therapy
    Patent number: 10463730
    Abstract: Therapeutic methods and vaccinia virus therefor are provided. The viruses are designed so that they accumulate in immunoprivileged tissues and cells, such as in tumors and other proliferating tissue and in inflamed tissues, compared to other tissues, cells and organs, so that they exhibit relatively low toxicity to host organisms. Combinations of the viruses and anti-cancer agents and uses thereof for treating cancer also are provided.
    Type: Grant
    Filed: October 21, 2016
    Date of Patent: November 5, 2019
    Assignee: Genelux Corporation
    Inventors: Aladar A. Szalay, Tatyana Timiryasova, Yong A. Yu, Qian Zhang
  • Oncolytic virus adjunct therapy with agents that increase virus infectivity
    Patent number: 10238700
    Abstract: Provided are adjunct therapies for use in combinations and compositions with an oncolytic virus, such as a vaccinia virus. The adjunct therapies include co-administration and co-formulation of a complement inhibitor and/or a lipid emulsion composition with the oncolytic virus. Also provided herein are therapeutic methods using the adjunct therapies for treatment of disease and conditions employing an oncolytic therapeutic virus, such as for the treatment of hyperproliferative diseases or conditions including tumors or cancers.
    Type: Grant
    Filed: December 31, 2014
    Date of Patent: March 26, 2019
    Assignee: Genelux Corporation
    Inventors: Aladar A. Szalay, Joseph Cappello, Nanhai G. Chen, Boris Minev
  • SMALLPOX VACCINE FOR CANCER TREATMENT
    Publication number: 20180326048
    Abstract: Disclosed herein are methods and compositions related to therapy for cancer. More specifically, the disclosed methods and compositions are related to the use of smallpox vaccine to induce an effective anti-tumor immune response.
    Type: Application
    Filed: July 24, 2018
    Publication date: November 15, 2018
    Inventors: Aladar Szalay, Boris Minev
  • Smallpox vaccine for cancer treatment
    Patent number: 10105436
    Abstract: Disclosed herein are methods and compositions related to therapy for cancer. More specifically, the disclosed methods and compositions are related to the use of smallpox vaccine to induce an effective anti-tumor immune response.
    Type: Grant
    Filed: August 11, 2016
    Date of Patent: October 23, 2018
    Assignee: Calidi Biotherapeutics, Inc.
    Inventors: Aladar Szalay, Boris Minev