Patents by Inventor Alain Balland

Alain Balland has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • HOMOGENEOUS ANTIBODY POPULATIONS
    Publication number: 20180105589
    Abstract: The present invention is generally directed to methods of producing an increase in the enrichment and/or recovery of preferred forms of monoclonal antibodies. More particularly, the invention relates to methods for eliminating disulfide heterogeneity in the hinge region of recombinant IgG2 antibody proteins.
    Type: Application
    Filed: September 5, 2017
    Publication date: April 19, 2018
    Inventors: Thomas M. DILLON, Pavel BONDARENKO, Jette WYPYCH, Martin J. ALLEN, Alain BALLAND, Margaret Speed RICCI, Amy GUO, Wenyan SHEN, Jeonghoon SUN, Christopher J. VEZINA
  • Homogeneous Antibody Populations
    Publication number: 20100226925
    Abstract: The present invention is generally directed to methods of producing an increase in the enrichment and/or recovery of preferred forms of monoclonal antibodies. More particularly, the invention relates to methods for eliminating disulfide heterogeneity in the hinge region of recombinant IgG2 antibody proteins.
    Type: Application
    Filed: September 11, 2008
    Publication date: September 9, 2010
    Applicant: AMGEN INC.
    Inventors: Thomas M. Dillon, Pavel Bondarenko, Jette Wypych, Martin J. Allen, Alain Balland, Margaret Speed Ricci, Amy Guo, Wenyan Shen, Jeonghoon Sun, Chris Vezina
  • Functional DNA block and plasmid coding for hirudin, transformed yeast, method for hirudin, hirudin obtained, and its pharmaceutical use
    Patent number: 5902735
    Abstract: The invention relates to a functional DNA block by means of which hirudin may be prepared from yeast, which block contains at least the sequence:-S.sub.tr -L.sub.ex -S.sub.cl -H geneH gene being the gene coding for hirudin or one of its variants,S.sub.tr is a DNA sequence containing the signals which provide for the transcription of the H gene by yeast,L.sub.ex is a leader sequence needed in order to obtain the excretion of the gene product,S.sub.cl is a DNA sequence coding for the site of cleavage by yscF proteinase, which cleavage site is unique and situated in the hirudin precursor immediately upstream from the H gene.The invention relates more especially to a functional DNA block in which the H gene codes for HV1.
    Type: Grant
    Filed: September 5, 1996
    Date of Patent: May 11, 1999
    Assignee: Noechst AG
    Inventors: Gerard Loison, Yves Lemoine, Nathalie Labat, Alain Balland
  • Functional DNA block and plasmid coding for hirudin, transformed yeast, method for preparing hirudin, hirudin obtained and its pharmaceutical use
    Patent number: 5591640
    Abstract: The invention relates to a functional DNA block by means of which hirudin may be prepared from yeast, which block contains at least the sequence:--S.sub.tr --L.sub.ex --S.sub.cl --H geneH gene being the gene coding for hirudin or one of its variants,S.sub.tr is a DNA sequence containing the signals which provide for the transcription of the H gene by yeast,L.sub.ex is a leader sequence needed in order to obtain the excretion of the gene product,S.sub.cl is a DNA sequence coding for the site of cleavage by yscF proteinase, which cleavage site is unique and situated in the hirudin precursor immediately upstream from the H gene,The invention relates more especially to a functional DNA block in which the H gene codes for HV1.
    Type: Grant
    Filed: March 16, 1995
    Date of Patent: January 7, 1997
    Assignee: Behringwerke A.G.
    Inventors: Gerard Loison, Yves Lemoine, Nathalie Labat, Alain Balland