Patents by Inventor Alain Boutonnier

Alain Boutonnier has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Reagent for the detection of Staphylococcus aureus by agglutination
    Patent number: 6686169
    Abstract: Reagents and methods for the detection of Staphylococcus aureus are provided. The reagents contain an antibody that binds to a capsular polysaccharide of type 5 of Staphylococcus aureus, and can be used in methods for detection of oxacillin resistant Staphylococcus aureus that escapes detection by agglutination in the presence of fibrinogen and antibodies directed against protein A of Staphylococcus.
    Type: Grant
    Filed: August 7, 2002
    Date of Patent: February 3, 2004
    Assignee: Institut Pasteur
    Inventors: Jean-Michel Fournier, Alain Boutonnier
  • Conjugate vaccine composed of the polysaccharide moiety of the lipopolysaccharide of Vibrio cholerae O139 bound to tetanus toxoid
    Publication number: 20030068324
    Abstract: The epidemic and pandemic potential of V. cholerae O139 is such that a vaccine against this newly emerged serogroup of V. cholerae is required. A conjugate made of the polysaccharide moiety (O-specific polysaccharide+core) of the lipopolysaccharide (LPS) of V. cholerae O139 (pmLPS) was prepared by derivatization of the pmLPS with adipic acid dihydrazide and coupling to tetanus toxoid (TT) by carbodiimide-mediated condensation. The immunologic properties of the conjugate were tested using BALB/c mice injected subcutaneously three times at 2 weeks interval and then a fourth time 4 weeks later. Mice were bled 7 days after each injection and then once each month for the following six months. LPS and TT antibody levels were determined by ELISA using immunoplates coated with either O139 LPS or TT. Both pmLPS and pmLPS-TT conjugate elicited low levels of IgM, peaking 5 weeks after the first immunization.
    Type: Application
    Filed: April 5, 2002
    Publication date: April 10, 2003
    Inventors: Jean-Michel Fournier, Alain Boutonnier
  • Reagent for the detection of Staphylococcus aureus by agglutination
    Publication number: 20030068662
    Abstract: Reagents and methods for the detection of Staphylococcus aureus are provided. The reagents contain an antibody that binds to a capsular polysaccharide of type 5 of Staphylococcus aureus, and can be used in methods for detection of oxacillin resistant Staphylococcus aureus that escapes detection by agglutination in the presence of fibrinogen and antibodies directed against protein A of Staphylococcus.
    Type: Application
    Filed: August 7, 2002
    Publication date: April 10, 2003
    Applicant: Institut Pasteur
    Inventors: Jean-Michel Fournier, Alain Boutonnier
  • Reagent for the detection of Staphylococcus aureus by agglutination
    Patent number: 6482602
    Abstract: Reagents and methods for the detection of Staphylococcus aureus are provided. The reagents contain an antibody that binds to a capsular polysaccharide of type 5 of Staphylococcus aureus, and can be used in methods for detection of oxacillin resistant Staphylococcus aureus that escapes detection by agglutination in the presence of fibrinogen and antibodies directed against protein A of Staphylococcus.
    Type: Grant
    Filed: August 8, 2000
    Date of Patent: November 19, 2002
    Assignee: Institut Pasteur
    Inventors: Jean-Michel Fournier, Alain Boutonnier
  • Reagent for the detection of Staphylococcus aureus by agglutination
    Patent number: 6156524
    Abstract: Reagents and methods for the detection of Staphylococcus aureus are provided. The reagents contain an antibody that binds to a capsular polysaccharide of type 5 of Staphylococcus aureus, and can be used in methods for detection of oxacillin resistant Staphylococcus aureus that escapes detection by agglutination in the presence of fibrinogen and antibodies directed against protein A of Staphylococcus.
    Type: Grant
    Filed: May 30, 1995
    Date of Patent: December 5, 2000
    Assignee: Institut Pasteur
    Inventors: Jean-Michel Fournier, Alain Boutonnier
  • Process for the preparation of capsular polysaccharides of staphylococci, the polysaccharides obtained, uses of these polysaccharides and strains for carrying out of the process
    Patent number: 4902616
    Abstract: The subject of the invention is a process for the preparation of capsular polysaccharides characteristic of Staphylococcus aureus, comprising the use of coagulase-negative strains of staphylococci for the preparation of these polysaccharides.The capsular polysaccharides obtained can be used for the preparation of vaccines against Staphylococcus aureus and diagnostic agents.
    Type: Grant
    Filed: August 2, 1988
    Date of Patent: February 20, 1990
    Assignee: Institut Pasteur
    Inventors: Jean-Michel Fournier, Anne Bouvet, Alain Boutonnier