Patents by Inventor Alain Brans

Alain Brans has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for measuring beta-lactam antibiotics
    Patent number: 9689021
    Abstract: The present invention relates to methods for determining the concentration of a free beta-lactam antibiotic in a biological sample. In particular, the present invention relates to methods for measuring a free beta-lactam antibiotic in a biological sample, comprising the steps of: (a) providing at least one class C beta-lactamase, a functional fragment or variant thereof; (b) providing at least one biological sample; (c) contacting said at least one class C beta-lactamase with said at least one biological sample; and (d) determining the concentration of said free beta-lactam antibiotic in said at least one biological sample.
    Type: Grant
    Filed: October 15, 2012
    Date of Patent: June 27, 2017
    Assignees: UNIVERSITÉ DE LIÈGE, UNIVERSITÉ CATHOLIQUE DE LOUVAIN, UNIVERSITÉ LIBRE DE BRUXELLES, UNIVERSITÉ DE MONS-HAINAUT
    Inventors: Alain Brans, Bernard Joris, Michael Delmarcelle, Jacqueline Marchand, Paul Tulkens, Catherine Hammaecher, Erik Goormaghtigh, Joel De Coninck
  • METHOD FOR MEASURING BETA-LACTAM ANTIBIOTICS
    Publication number: 20140243241
    Abstract: The present invention relates to methods for determining the concentration of a free beta-lactam antibiotic in a biological sample. In particular, the present invention relates to methods for measuring a free beta-lactam antibiotic in a biological sample, comprising the steps of: (a) providing at least one class C beta-lactamase, a functional fragment or variant thereof; (b) providing at least one biological sample; (c) contacting said at least one class C beta-lactamase with said at least one biological sample; and (d) determining the concentration of said free beta-lactam antibiotic in said at least one biological sample.
    Type: Application
    Filed: October 15, 2012
    Publication date: August 28, 2014
    Applicants: UNIVERSITE DE LIEGE, UNIVERSITE DE MONS, UNIVERSITE LIBRE DE BRUXELLES, UNIVERSITE CATHOLIQUE DE LOUVAIN
    Inventors: Alain Brans, Bernard Joris, Michael Delmarcelle, Jacqueline Marchand, Paul Tulkens, Catherine Hammaecher, Erik Goormaghtigh, Joel De Coninck
  • Hybrid proteins of active-site serine ?-lactamase
    Patent number: 7745193
    Abstract: The present invention refers to a recombinant nucleotide sequence which codes upon expression for at least a part of a bifunctional hybrid active-site serine ?-lactamase protein, wherein the ?-lactamase protein is bearing at least one heterologous sequence, wherein in that the hybrid protein is having two functions, the first function is associated with the ?-lactamase portion and the second function is associated with the heterologous sequence having a biological function which is different from the first function.
    Type: Grant
    Filed: January 17, 2005
    Date of Patent: June 29, 2010
    Assignee: Universite de Liege
    Inventors: Fabrizio Giannotta, Patrice Filee, Moreno Galleni, Jean-Marie Frere, Bernard Joris, Alain Brans, Nadia Ruth
  • Hybrid proteins of active-site serine beta-lactamase
    Publication number: 20070161040
    Abstract: The present invention refers to a recombinant nucleotide sequence which codes upon expression for at least a part of a bifunctional hybrid active-site serine ?-lactamase protein, wherein the ?-lactamase protein is bearing at least one heterologous sequence, wherein in that the hybrid protein is having two functions, the first function is associated with the ?-lactamase portion and the second function is associated with the heterologous sequence having a biological function which is different from the first function.
    Type: Application
    Filed: January 17, 2005
    Publication date: July 12, 2007
    Inventors: Fabrizio Giannotta, Patrice Filee, Moreno Galleni, Jean-Marie Frere, Bernard Joris, Alain Brans, Nadia Ruth
  • Novel use of lipopeptide preparations
    Publication number: 20060166869
    Abstract: The invention relates to the use of lipopeptide preparations as anti-tilted-peptide agents, which are able to inhibit or limit the destabilization effect of tilted peptides on hydrophobic/hydrophilic interfaces, for instance on membranes. The lipopeptides include surfactins, iturins, and fengycins. The invention also relates to a process for the production of the lipopeptide preparations.
    Type: Application
    Filed: June 27, 2003
    Publication date: July 27, 2006
    Inventors: Magali Deleu, Robert Brasseur, Michel Paquot, Herve Legros, Samuel Dufour, Philippe Jacques, Jacqueline Destain, Philippe Thonart, Alain Brans, Bernard Joris, Jean-Marie Frerc