Patents by Inventor Alain Burgos

Alain Burgos has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 9102658
    Abstract: The invention relates to a process for the preparation of a compound of formula (I) wherein R1 is C1C6 alkyl or benzyl by reacting a compound of formula (II) wherein R1 is as defined for formula (I) with 2-quinoline carboxaldehyde. The process is suitable for use on an industrial scale.
    Type: Grant
    Filed: December 14, 2012
    Date of Patent: August 11, 2015
    Assignee: Atopix Therapeutics Limited
    Inventors: Jacques Tonnel, Tony Pintus, Alain Burgos
  • Patent number: 8981127
    Abstract: The present invention relates to a process for the preparation of nebivolol and, more particularly, to an improved process of synthesizing an alpha-haloketone of formula a key intermediate in the preparation of nebivolol.
    Type: Grant
    Filed: September 22, 2009
    Date of Patent: March 17, 2015
    Assignee: Zach System
    Inventors: Yvon Derrien, Eric Chenard, Alain Burgos
  • Publication number: 20140350264
    Abstract: The invention relates to a process for the preparation of a compound of formula (I) wherein R1 is C1C6 alkyl or benzyl by reacting a compound of formula (II) wherein R1 is as defined for formula (I) with 2-quinoline carboxaldehyde. The process is suitable for use on an industrial scale.
    Type: Application
    Filed: December 14, 2012
    Publication date: November 27, 2014
    Inventors: Jacques Tonnel, Tony Pintus, Alain Burgos
  • Patent number: 8198054
    Abstract: This disclosure relates to the synthesis of the compound of formula (I) according to Scheme A below: in which R1, R2 and R3, which may be identical or different, represent, individually and independently, an alkyl group, characterized by an enzymatic hydrolysis reaction that involves placing the compound of formula (II) in contact with an enzyme that performs a chemoselective hydrolysis of only one of the two ester functions of the compound of formula (II) to obtain the compound of formula (I).
    Type: Grant
    Filed: January 22, 2008
    Date of Patent: June 12, 2012
    Assignees: Zach System, Novacta Biosystem Limited
    Inventors: Alain Burgos, Jean-Claude Caille, Michelle Lorraine-Gradley
  • Publication number: 20110237808
    Abstract: The present invention relates to a process for the preparation of nebivolol and, more particularly, to an improved process of synthesizing an alpha-haloketone of formula a key intermediate in the preparation of nebivolol.
    Type: Application
    Filed: September 22, 2009
    Publication date: September 29, 2011
    Applicant: ZACH SYSTEM
    Inventors: Yvon Derrien, Eric Chenard, Alain Burgos
  • Patent number: 7884243
    Abstract: A process for the production of ene-amide derivatives represented by the formula (I) wherein R1 and R2 and R3 are independently a hydrogen atom, an alkyl, a cycloalkyl, a cycloalkylalkyl, an alkylaryl, an aryl, a heterocycle, a cyano, an alkoxy, an aryloxy, a carboxyl, a carbamoyl, —CONR5R6 (in which R5 and R6 are independently an alkyl, arylalkyl or aryl group said ring being substituted or not with a functional group or with R5) or —COOR5 group (in which R5 is an alkyl, alkylaryl or aryl group), said alkyl, cycloalkyl, cycloalkylalkyl, alkylaryl and aryl groups being substituted or not with a functional group or with R5; or R1 and R2 taken together, may form a ring (which terms includes mono-, di- and higher polycyclic ring systems); R4 is a hydrogen atom, an alkyl, an aryl, an alkylaryl, said groups are substituted or not with a halogen atom as Cl, Br, or F; X is an oxygen atom or a leaving group and m is an integer 1 or 2; when m is 1 then X is a leaving group; when m is 2 then X is a oxygen atom, whi
    Type: Grant
    Filed: December 22, 2004
    Date of Patent: February 8, 2011
    Assignee: Zach System
    Inventors: Alain Burgos, Blandine Bertrand, Sonia Roussiasse, Jean-François Pluvie, Sylvie Blanchet, Juliette Martin, Florence Perrin, Françoise Bourdeau
  • Publication number: 20100068770
    Abstract: The invention relates to a synthesis process. This process relates to the synthesis of the compound of formula (I) according to Scheme A below: in which R1, R2 and R3, which may be identical or different, represent, individually and independently, an alkyl group, characterized by an enzymatic hydrolysis reaction that involves placing the compound of formula (II) in contact with an enzyme that performs a chemoselective hydrolysis of only one of the two ester functions of the compound of formula (II) to obtain the compound of formula (I). The invention allows the industrial preparation of the intermediate of formula (I), which may be used for the preparation of the pharmaceutical active principle repaglinide.
    Type: Application
    Filed: January 22, 2008
    Publication date: March 18, 2010
    Applicants: ZACH SYSTEM, NOVACTA BIOSYSTEMS LIMITED
    Inventors: Alain Burgos, Jean-Claude Caille, Michelle Lorraine Gradley
  • Patent number: 7586015
    Abstract: A process is used for the preparation of 1,3,2-oxazaborolidine compounds. This process prepares compounds of formula (I) or (IA): in which: R1 is an alkyl or an aryl; and R2, R3, R4 and R5 are especially a hydrogen atom or an alkyl, wherein the following are reacted in two steps: a) a boric precursor compound with an acetal compound to give a boronate compound; and b) the boronate compound with an amino alcohol compound. This process avoids by-products and exhibits a very good stereospecificity.
    Type: Grant
    Filed: January 25, 2007
    Date of Patent: September 8, 2009
    Assignee: Zach System
    Inventors: Alain Burgos, Stëphane Frein
  • Publication number: 20090131688
    Abstract: The invention concerns a novel method for synthesis of 4-benzofuran-carboxylic acid or alkyl ester thereof. This method is characterized in that a reaction for aromatization of a compound of formula (II) is performed for the synthesis of the compound of formula (I), according to the scheme A2 below: wherein R independently represents hydrogen or a linear or branched C1-15 alkyl group. With the invention, it is possible to industrially synthesize 4-benzofuran-carboxylic acid or alkyl ester thereof with good yield and very good purity.
    Type: Application
    Filed: February 25, 2008
    Publication date: May 21, 2009
    Applicant: ZACH SYSTEM
    Inventors: Alain Burgos, Martine Maruani, Florence Perrin, Stephane Frein
  • Patent number: 7462742
    Abstract: An in situ or one-pot process for the preparation of the compounds of formula (I) uses a compound of general formula (I): and includes: a) the hydrogenation of a nitrile group of the compound of general formula (II): in which R1 to R4 are especially H or alkyl and n varies from 0 to 4, in the presence of a hydrogenation catalyst, a methylating agent and an organic acid as solvent, and at a temperature Ta below the initiation temperature of a reductive amination reaction, to give a primary amine from the nitrile group; and b) the reductive amination of the primary amine in the presence of hydrogen, at a temperature Tb above Ta, to give the dimethylated amine of general formula (I) by activation of the methylating age.
    Type: Grant
    Filed: January 23, 2007
    Date of Patent: December 9, 2008
    Assignee: Zach System
    Inventors: Alain Burgos, Jacques Tonnel, Valéry Dambrin, Denis Lucet, Patricia Poirier
  • Patent number: 7456320
    Abstract: A process for the preparation of optically active substituted alpha-amino-indane derivatives of formula (I), which include: an asymmetric hydrogenation reaction of an en-amide derivative of formula (III) in presence of hydrogen and an optically active catalyst, in order to obtain an amide derivative of formula (II), a hydrolysis reaction of the amide derivative of formula (II) obtained in the previous step, in order to obtain optically active substituted alpha-amino-indane derivatives of formula (I).
    Type: Grant
    Filed: February 21, 2005
    Date of Patent: November 25, 2008
    Assignee: ZaCh System
    Inventors: Blandine Bertrand, Sylvie Blanchet, Alain Burgos, Juliette Martin, Florence Perrin, Sonia Roussiasse, Yvon Derrien
  • Publication number: 20080139851
    Abstract: A process is used for the preparation of 1,3,2-oxazaborolidine compounds. This process prepares compounds of formula (I) or (IA): in which: R1 is an alkyl or an aryl; and R2, R3, R4 and R5 are especially a hydrogen atom or an alkyl, wherein the following are reacted in two steps: a) a boric precursor compound with an acetal compound to give a boronate compound; and b) the boronate compound with an amino alcohol compound. This process avoids by-products and exhibits a very good stereospecificity.
    Type: Application
    Filed: January 25, 2007
    Publication date: June 12, 2008
    Applicant: PPG-SIPSY
    Inventors: Alain Burgos, Stephane Frein
  • Publication number: 20080125606
    Abstract: An in situ or one-pot process for the preparation of the compounds of formula (I) uses a compound of general formula (I): and includes: a) the hydrogenation of a nitrile group of the compound of general formula (II): in which R1 to R4 are especially H or alkyl and n varies from 0 to 4, in the presence of a hydrogenation catalyst, a methylating agent and an organic acid as solvent, and at a temperature Ta below the initiation temperature of a reductive amination reaction, to give a primary amine from the nitrile group; and b) the reductive amination of the primary amine in the presence of hydrogen, at a temperature Tb above Ta, to give the dimethylated amine of general formula (I) by activation of the methylating age.
    Type: Application
    Filed: January 23, 2007
    Publication date: May 29, 2008
    Applicant: PPG-SIPSY
    Inventors: Alain Burgos, Jacques Tonnel, Valerie Dambrin, Denis Lucet, Patricia Poirier
  • Patent number: 7378521
    Abstract: The invention relates to a process for the preparation of substituted 2-vinyl-2-arylmorpholine derivatives as described herein. This invention also relates to 2-vinyl-2-arylmorpholine derivatives as well as intermediates therefor.
    Type: Grant
    Filed: March 29, 2007
    Date of Patent: May 27, 2008
    Assignee: Sanofi-Aventis
    Inventors: Alain Aulombard, Francoise Bernon, Alain Burgos, Claude Cabos, Eric Lucas, Sabrina Bonnefoy
  • Patent number: 7365212
    Abstract: A process for the in situ preparation of chiral compounds derived from oxazaborolidine-borane complexes, wherein a metal borohydride, a Lewis base and an inorganic acid ester are brought together and an optically active amino alcohol and optionally a halide are then added. The compound obtained is a complex that is useful as a catalyst in asymmetric reduction reactions. The reaction is performed by adding the substance to be reduced, particularly prochiral ketones or ether oximes, in order to synthesize chiral alcohols or chiral amines.
    Type: Grant
    Filed: October 11, 2004
    Date of Patent: April 29, 2008
    Assignee: ZaCh System S.p.A.
    Inventors: Alain Burgos, Blandine Bertrand, Stéphane Frein, Jean-François Pluvie, Sonia Roussiasse
  • Patent number: 7262326
    Abstract: A process for preparing indanylamine and aminotetralin derivatives from indanone or tetralone oximes by acylating the oximes with an organic anhydride, followed by catalytic hydrogenation in the presence of an organic anhydride with subsequent hydrolysis is described. The process is commercially feasible providing indanylamine and aminotetralin derivatives in high yield that are useful as intermediates in the production of therapeutically active compounds. Also described are novel intermediates, 1-indanone O-acetyl oximes and 1-tetralone O-acetyl oximes.
    Type: Grant
    Filed: September 7, 2005
    Date of Patent: August 28, 2007
    Assignee: Teva Pharmaceuticals Industries Ltd.
    Inventors: Sylvie Blanchet, Bertrand Blandine, Alain Burgos, Yvon Derrien, Marie-Laure Moreau
  • Publication number: 20070191640
    Abstract: A process is for the preparation of optically active substituted alpha-indanyl amide derivatives of formula (I), which include: an asymmetric hydrogenation reaction of an en-amide derivative of formula (III) in presence of hydrogen and an optically active catalyst, in order to obtain an amide derivative of formula (II), a hydrolysis reaction of the amide derivative of formula (II) obtained in the previous step, in order to obtain optically active-substituted alpha-indanyl amide derivatives of formula (I).
    Type: Application
    Filed: February 21, 2005
    Publication date: August 16, 2007
    Applicant: PPG-SIPSY
    Inventors: Blandine Bertrand, Sylvie Blanchet, Alain Burgos, Juliette Martin, Florence Perrin, Sonia Roussiasse, Yvon Derrien
  • Publication number: 20070167623
    Abstract: The invention relates to a process for the preparation of substituted 2-vinyl-2-arylmorpholine derivatives as described herein. This invention also relates to 2-vinyl-2-arylmorpholine derivatives as well as intermediates therefor.
    Type: Application
    Filed: March 29, 2007
    Publication date: July 19, 2007
    Applicant: SANOFI-AVENTIS
    Inventors: Alain AULOMBARD, Francoise BERNON, Sabrina BONNEFOY, Alain BURGOS, Claude CABOS, Eric LUCAS
  • Publication number: 20070129573
    Abstract: A process for the production of ene-amide derivatives represented by the formula (I) wherein R1 and R2 and R3 are independently a hydrogen atom, an alkyl, a cycloalkyl, a cycloalkylalkyl, an alkylaryl, an aryl, a heterocycle, a cyano, an alkoxy, an aryloxy, a carboxyl, a carbamoyl, —CONR5R6 (in which R5 and R6 are independently an alkyl, arylalkyl or aryl group said ring being substituted being substituted or not with a functional group or with R5) or —COOR5 group (in which R5 is an alkyl, alkylaryl or aryl group), said alkyl, cycloalkyl, cycloalkylalkyl, alkylaryl and aryl groups being substituted or not with a functional group or with R5; or R1 and R2 taken together, may form a ring (which terms includes mono-, di- and higher polycyclic ring systems); R4 is a hydrogen atom, an alkyl, an aryl, an alkylaryl, said groups substituted or not with a halogen atom as Cl, Br, or F; X is an oxygen atom or a leaving group and m is an integer 1 or 2; when m is 1 then X is a leaving group; when m is 2 then X is a o
    Type: Application
    Filed: December 22, 2004
    Publication date: June 7, 2007
    Applicant: PPG-SIPSY
    Inventors: Alain Burgos, Blandine Bertrand, Sonia Roussiasse, Jean-Francois Pluvie, Sylvie Blanchet, Juliette Martin, Florence Perrin, Francoise Bourdeau
  • Patent number: 7223860
    Abstract: The invention relates to a process for the preparation of substituted 2-vinyl-2-arylmorpholine derivatives as described herein. This invention also relates to 2-vinyl-2-arylmorpholine derivatives as well as intermediates therefor.
    Type: Grant
    Filed: March 8, 2006
    Date of Patent: May 29, 2007
    Assignee: Sanofi-Aventis
    Inventors: Alain Aulombard, Francoise Bernon, Alain Burgos, Claude Cabos, Eric Lucas, Sabrina Bonnefoy