Patents by Inventor Alain David

Alain David has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Treatment of a Senescence-Associated Ocular Disease or Disorder Using a Bcl-xL Selective Inhibitor
    Publication number: 20240115563
    Abstract: This invention establishes a new paradigm for treatment of Parkinson's disease (PD) by eliminating senescent cells that reside in or around the site of the disease pathophysiology. Exposure of test subjects to the herbicide paraquat (PQ) increases the risk for developing Parkinson's disease. The data in this disclosure show that PQ induces a senescence arrest and SASP in astrocytes, in culture and in vivo in mice, and senescent cell markers were present in astrocytes in midbrain tissue from PD patients. In a transgenic mouse model, senescent cell ablation protected against PQ-induced PD-like neuropathology. Removal of senescent cells from affected sites using small molecule agents that specifically target senescent cells can help prevent or ameliorate signs and symptoms of the disease.
    Type: Application
    Filed: August 7, 2023
    Publication date: April 11, 2024
    Inventors: Remi-Martin Laberge, Judith Campisi, Marco Demaria, Bennett G. Childs, Jan M. A. Van Deursen, Nathaniel David, Alain Philippe Vasserot
  • Esterases and uses thereof
    Patent number: 11926851
    Abstract: The present invention relates to esterases, more particularly to esterase variants having improved activity and/or improved thermostability compared to the esterase of SEQ ID NO: 1 and the uses thereof for degrading polyester containing material, such as plastic products. The esterases of the invention are particularly suited to degrade polyethylene terephthalate, and material containing polyethylene terephthalate.
    Type: Grant
    Filed: December 22, 2022
    Date of Patent: March 12, 2024
    Assignee: CARBIOS
    Inventors: Benoît David, Isabelle Andre, Maher Ben Khaled, Sophie Duquesne, Alain Marty
  • Microparticles, preparation thereof and applications thereof in biology, particularly in the culture of human diploid cells
    Patent number: 4373027
    Abstract: These microparticles are formed, at least on their surface, from a reticulated protein. (FIG. 1).
    Type: Grant
    Filed: December 5, 1980
    Date of Patent: February 8, 1983
    Inventors: Armand Berneman, Alain David, Florian Horaud, Emile Segard