Patents by Inventor Alain GEY

Alain GEY has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • IL-15 AND IL-15RALPHA SUSHI DOMAIN BASED MODULOKINES
    Publication number: 20220193199
    Abstract: The present invention relates to an immunocytokine comprising (a) a conjugate, and (b) an immunomodulatory antibody or a fragment thereof directly or indirectly linked by covalence to said conjugate, wherein said conjugate comprises (i) a polypeptide comprising the amino acid sequence of the interleukin 15 or derivatives thereof, and a polypeptide comprising the amino acid sequence of the sushi domain of the IL-15R? or derivatives thereof; and uses thereof.
    Type: Application
    Filed: March 11, 2022
    Publication date: June 23, 2022
    Inventors: Alain GEY, Eric TARTOUR, David BECHARD
  • IL-15 and IL-15RAPLHA sushi domain based immunocytokines
    Patent number: 11273204
    Abstract: The present invention relates to an immunocytokine comprising (a) a conjugate, and (b) an immunomodulatory antibody or a fragment thereof directly or indirectly linked by covalence to said conjugate, wherein said conjugate comprises (i) a polypeptide comprising the amino acid sequence of the interleukin 15 or derivatives thereof, and a polypeptide comprising the amino acid sequence of the sushi domain of the IL-15R? or derivatives thereof; and uses thereof.
    Type: Grant
    Filed: August 8, 2014
    Date of Patent: March 15, 2022
    Assignees: CYTUNE PHARMA, UNIVERSITE DE PARIS, ASSISTANCE PUBLIQUE—HOPITAUX DE PARIS, INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE (INSERM)
    Inventors: Alain Gey, Eric Tartour, David Bechard
  • USE OF PD-1 AND TIM-3 AS A MEASURE FOR CD8+ CELLS IN PREDICTING AND TREATING RENAL CELL CARCINOMA
    Publication number: 20200264165
    Abstract: The present invention relates to a method for predicting the survival time of a subject suffering from renal cell carcinoma comprising the steps of: i) quantifying the percent of CD8+ T cells co-expressing PD-1 and Tim-3 in a tumor tissue sample obtained from the subject, ii) comparing the percent quantified at step i), with its corresponding predetermined reference value and iii) concluding that the subject will have a short survival time when the percent of CD8+ T cells co-expressing PD-1 and Tim-3 is higher than its corresponding predetermined reference value or concluding that the subject will have a long survival time when the percent of CD8+ T cells co-expressing PD-1 and Tim-3 is lower than its corresponding predetermined reference value.
    Type: Application
    Filed: January 3, 2017
    Publication date: August 20, 2020
    Inventors: Eric TARTOUR, Charles DARIANE, Clemence GRANIER, Alain GEY
  • IL-15 AND IL-15RAPLHA SUSHI DOMAIN BASED MODULOKINES
    Publication number: 20160175459
    Abstract: The present invention relates to an immunocytokine comprising (a) a conjugate, and (b) an immunomodulatory antibody or a fragment thereof directly or indirectly linked by covalence to said conjugate, wherein said conjugate comprises (i) a polypeptide comprising the amino acid sequence of the interleukin 15 or derivatives thereof, and a polypeptide comprising the amino acid sequence of the sushi domain of the IL-15R? or derivatives thereof; and uses thereof.
    Type: Application
    Filed: August 8, 2014
    Publication date: June 23, 2016
    Inventors: Alain GEY, Eric TARTOUR, David BECHARD