Patents by Inventor Alain Israel
Alain Israel has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20140336126Abstract: The invention relates to Optineurin-derived polypeptide(s) consisting of a polypeptidic sequence disclosed in SEQ ID no2, which represents the portion of the wild-type human Optineurin protein sequence from its amino-acid residue 131 to its amino-acid residue 297, or having a polypeptidic sequence encompassing the polypeptidic sequence disclosed in SEQ ID no2, or having a polypeptidic sequence derived from the polypeptidic sequence disclosed in SEQ ID no2 to the exclusion of the wild-type Optineurin protein. The polypeptide(s) of the invention retain one, any combination of two, or three of the following functional properties: the capacity to bind Rab8 protein, when the latter are associated with the Golgi apparatus of a cell, the capacity to bind MYPT1 protein, when said protein is engaged in a Myosin-Phosphatase (MP) complex, the capacity to be phosphorylated by Plk1.Type: ApplicationFiled: December 18, 2012Publication date: November 13, 2014Inventors: Robert Serge Weil, David Kachaner, Josina Côrte-Real Filipe, Emmanuel François Laplantine, Alain Israël
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Patent number: 8790883Abstract: The present invention relates to polypeptides that inhibit the NF-?B signaling pathway and polynucleotides encoding the same. The present invention further provides methods for the modulation of and/or treatment of inflammatory responses, oncogenesis, viral infection; the regulation of cell proliferation and apoptosis; and regulation of B or T lymphocytes in antigenic stimulation, by administering the polypeptides of the present invention to a subject in need thereof. Finally, the present invention provides a method of identifying polypeptides that modulate oligomerization of NEMO.Type: GrantFiled: April 24, 2008Date of Patent: July 29, 2014Assignee: Institut PasteurInventors: Fabrice Agou, Gilles Courtois, Alain Israel, Michel Vernon, Francois Traincard, Shoji Yamaoka
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Publication number: 20110182811Abstract: The present invention relates to nucleotide sequences encoding a modulator of NF-?B, and to the polypeptides encoded by the nucleotide sequences. In particular, the invention relates to nucleotide sequences and the polypeptides encoded thereby, wherein the polypeptides are involved in the response to NF-?B-activating stimuli, including HTLV-1 Tax, LPS, PMA and IL-1. The invention also relates to antibodies to the modulator of NF-?B, methods of detecting modulator of NF-?B using the antibodies, methods of treatment associated with NF-?B activation and to methods of identifying compounds which modulate the activity of the modulator of NF-?B.Type: ApplicationFiled: July 21, 2010Publication date: July 28, 2011Applicant: INSTITUT PASTEURInventors: Shoji YAMAOKA, Gilles COURTOIS, Alain ISRAEL, Robert WEIL
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Publication number: 20100240040Abstract: The invention relates to methods for screening for selective modulator of NF-?B pathway activation. The invention concerns methods for primary screening molecules that potentially modulate (activate or inhibit) the NF-?B pathway activation by identifying and selecting molecules modulate the interaction of NEMO with other proteins. The invention also concerns methods for secondary screening for modulator (activator or inhibitor) of the NF-?B pathway activation.Type: ApplicationFiled: June 20, 2008Publication date: September 23, 2010Applicants: INSTITUT PASTEUR, Centre National De La Recherche Scient.Inventors: Fabrice Agou, Jeanne Chiaravalli, Yves-Marie Coic, Francoise Baleux, Alain Israel, Michel Veron
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Publication number: 20100144615Abstract: The present invention relates to nucleotide sequences encoding a modulator of NF-?B, and to the polypeptides encoded by the nucleotide sequences. In particular, the invention relates to nucleotide sequences and the polypeptides encoded thereby, wherein the polypeptides are involved in the response to NF-?B-activating stimuli, including HTLV-1 Tax, LPS, PMA and IL-1. The invention also relates to antibodies to the modulator of NF-?B, methods of detecting modulator of NF-?B using the antibodies, methods of treatment associated with NF-?B activation and to methods of identifying compounds which modulate the activity of the modulator of NF-?B.Type: ApplicationFiled: August 13, 2008Publication date: June 10, 2010Applicant: INSTITUT PASTEURInventors: Shoji Yamaoka, Gilles Courtois, Alain Israel, Robert Weil
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Patent number: 7700553Abstract: The present invention relates to polypeptides that inhibit the NF-&kgr;B signaling pathway and polynucleotides encoding the same. The present invention further provides methods for the modulation of and/or treatment of inflammatory responses, oncogenesis, viral infection; the regulation of cell proliferation and apoptosis; and regulation of B or T lymphocytes in antigenic stimulation, by administering the polypeptides of the present invention to a subject in need thereof. Finally, the present invention provides a method of identifying polypeptides that modulate oligomerization of NEMO.Type: GrantFiled: September 24, 2004Date of Patent: April 20, 2010Assignees: Institut Pasteur, INSERM (Institut National de la Sante et de la Recherche Medicale), Centre National De La Recherche ScientifiqueInventors: Fabrice Agou, Gilles Courtois, Alain Israel, Michel Veron, Francois Traincard, Shoji Yamaoka, Yves-Marie Coic, Francoise Baleux
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Publication number: 20090061480Abstract: The present invention relates to nucleotide sequences encoding a modulator of NF-?B, and to the polypeptides encoded by the nucleotide sequences. In particular, the invention relates to nucleotide sequences and the polypeptides encoded thereby, wherein the polypeptides are involved in the response to NF-?B-activating stimuli, including HTLV-1 Tax, LPS, PMA and IL-1. The invention also relates to antibodies to the modulator of NF-?B, methods of detecting modulator of NF-?B using the antibodies, methods of treatment associated with NF-?B activation and to methods of identifying compounds which modulate the activity of the modulator of NF-?B.Type: ApplicationFiled: February 27, 2007Publication date: March 5, 2009Applicant: INSTITUT PASTEURInventors: Shoji Yamaoka, Gilles Courtois, Alain Israel, Robert Weil
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Publication number: 20080242601Abstract: The present invention relates to polypeptides that inhibit the NF-&kgr; B signaling pathway and polynucleotides encoding the same. The present invention further provides methods for the modulation of and/or treatment of inflammatory responses, oncogenesis, viral infection; the regulation of cell proliferation and apoptosis; and regulation of B or T lymphocytes in antigenic stimulation, by administering the polypeptides of the present invention to a subject in need thereof. Finally, the present invention provides a method of identifying polypeptides that modulate oligomerization of NEMO.Type: ApplicationFiled: September 24, 2004Publication date: October 2, 2008Applicants: Institute Pasteur, Inserm (Inst.Nat.de la Sante et de la Rech.Med., CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUEInventors: Fabrice Agou, Gilles Courtois, Alain Israel, Michel Veron, Francois Traincard, Shoji Yamaoka, Yves-Marie Coic, Francoise Baleux
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Publication number: 20080207517Abstract: The present invention relates to polypeptides that inhibit the NF-?B signaling pathway and polynucleotides encoding the same. The present invention further provides methods for the modulation of and/or treatment of inflammatory responses, oncogenesis, viral infection; the regulation of cell proliferation and apoptosis; and regulation of B or T lymphocytes in antigenic stimulation, by administering the polypeptides of the present invention to a subject in need thereof. Finally, the present invention provides a method of identifying polypeptides that modulate oligomerization of NEMO.Type: ApplicationFiled: April 24, 2008Publication date: August 28, 2008Applicant: INSTITUT PASTEURInventors: Fabrice AGOU, Gilles Courtois, Alain Israel, Michel Vernon, Francois Traincard, Shoji Yamaoka
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Patent number: 7390872Abstract: The present invention relates to polypeptides that inhibit the NF-?B signaling pathway and polynucleotides encoding the same. The present invention further provides methods for the modulation of and/or treatment of inflammatory responses, oncogenesis, viral infection; the regulation of cell proliferation and apoptosis; and regulation of B or T lymphocytes in antigenic stimulation, by administering the polypeptides of the present invention to a subject in need thereof. Finally, the present invention provides a method of identifying polypeptides that modulate oligomerization of NEMO.Type: GrantFiled: September 24, 2004Date of Patent: June 24, 2008Assignee: Institut PasteurInventors: Fabrice Agou, Gilles Courtois, Alain Israel, Michel Veron, Francois Traincard, Shoji Yamaoka
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Publication number: 20050220792Abstract: The present invention relates to polypeptides that inhibit the NF-?B signaling pathway and polynucleotides encoding the same. The present invention further provides methods for the modulation of and/or treatment of inflammatory responses, oncogenesis, viral infection; the regulation of cell proliferation and apoptosis; and regulation of B or T lymphocytes in antigenic stimulation, by administering the polypeptides of the present invention to a subject in need thereof. Finally, the present invention provides a method of identifying polypeptides that modulate oligomerization of NEMO.Type: ApplicationFiled: September 24, 2004Publication date: October 6, 2005Applicant: INSTITUT PASTEURInventors: Fabrice Agou, Gilles Courtois, Alain Israel, Michel Veron, Francois Traincard, Shoji Yamaoka
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Patent number: 6824972Abstract: Incontinentia Pigmenti (IP) is a neurocutaneous genodermatosis that segregates as an X-linked dominant disorder with a high probability of prenatal male lethality. A locus in Xq28 containing NF-&kgr;B Essential Modulator, a gene product involved in the activation of NF-kB and central to many pro-inflammatory and apoptotic pathways, contains mutations in the majority of cases of IP. Disclosed are methods, compositions and kits directed to a defect in a NF-&kgr;B related disease such as IP.Type: GrantFiled: May 22, 2001Date of Patent: November 30, 2004Assignees: Baylor College of Medicine, Cambridge University Technical Services Limited, Consiglio Nazionale Delle Richerche, INSERM, L'Institut PasteurInventors: Sue J. Kenwrick, Hayley Woffendin, Arnold Munnich, Asmae Smahi, Alain Israel, Annemarie Poustka, Nina Heiss, Michele D'Urso, Richard A. Lewis, David L. Nelson, Swaroop Aradhya, Moise Levy
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Patent number: 6680366Abstract: The present invention relates to nucleotide sequences encoding a modulator of NF-&kgr;B, and to the polypeptides encoded by the nucleotide sequences. In particular, the invention relates to nucleotide sequences and the polypeptides encoded thereby, wherein the polypeptides are involved in the response to NF-&kgr;B-activating stimuli, including HTLV-1 Tax, LPS, PMA and IL-1. The invention also relates to antibodies to the modulator of NF-&kgr;B, methods of detecting modulator of NF-&kgr;B using the antibodies, methods of treatment associated with NF-&kgr;B activation and to methods of identifying compounds which modulate the activity of the modulator of NF-&kgr;B.Type: GrantFiled: February 22, 1999Date of Patent: January 20, 2004Assignee: Institut PasteurInventors: Shoji Yamaoka, Gilles Courtois, Alain Israel, Robert Weil
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Publication number: 20030228667Abstract: The present invention relates to nucleotide sequences encoding a modulator of NF-&kgr;B, and to the polypeptides encoded by the nucleotide sequences. In particular, the invention relates to nucleotide sequences and the polypeptides encoded thereby, wherein the polypeptides are involved in the response to NF-&kgr;B-activating stimuli, including HTLV-1 Tax, LPS, PMA and IL-1. The invention also relates to antibodies to the modulator of NF-&kgr;B, methods of detecting modulator of NF-&kgr;B using the antibodies, methods of treatment associated with NF-&kgr;B activation and to methods of identifying compounds which modulate the activity of the modulator of NF-&kgr;B.Type: ApplicationFiled: April 8, 2003Publication date: December 11, 2003Applicant: INSTITUT PASTEURInventors: Shoji Yamaoka, Gilles Courtois, Alain Israel, Robert Weil
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Publication number: 20030059911Abstract: The present invention relates to nucleotide sequences encoding a modulator of NF-&kgr;B, and to the polypeptides encoded by the nucleotide sequences. In particular, the invention relates to nucleotide sequences and the polypeptides encoded thereby, wherein the polypeptides are involved in the response to NF-&kgr;B-activating stimuli, including HTLV-1 Tax, LPS, PMA and IL-1. The invention also relates to antibodies to the modulator of NF-&kgr;B, methods of detecting modulator of NF-&kgr;B using the antibodies, methods of treatment associated with NF-&kgr;B activation and to methods of identifying compounds which modulate the activity of the modulator of NF-&kgr;B.Type: ApplicationFiled: July 8, 2002Publication date: March 27, 2003Applicant: INSTITUT PASTEURInventors: Shoji Yamaoka, Gilles Courtois, Alain Israel, Robert Weil
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Publication number: 20030032055Abstract: Incontinentia Pigmenti (IP) is a neurocutaneous genodermatosis that segregates as an X-linked dominant disorder with a high probability of prenatal male lethality. A locus in Xq28 containing NF-&kgr;B Essential Modulator, a gene product involved in the activation of NF-kB and central to many pro-inflammatory and apoptotic pathways, contains mutations in the majority of cases of IP. Disclosed are methods, compositions and kits directed to a defect in a NF-&kgr;B related disease such as IP.Type: ApplicationFiled: May 22, 2001Publication date: February 13, 2003Inventors: Sue J. Kenwrick, Hayley Woffendin, Arnold Munnich, Asmae Smahi, Alain Israel, Annemarie Poustka, Nina Heiss, Michele D'Urso, Richard Alan Lewis, David L. Nelson, Swaroop Aradhya, Moise Levy