Patents by Inventor Alain Joliot

Alain Joliot has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • POLYPEPTIDES BINDING SELECTIVELY HEPARIN OR HEPARAN SULFATE GLYCOSAMINOGLYCANS AND CELL-PENETRATING POLYPEPTIDES COMPRISING THE SAME
    Publication number: 20240053345
    Abstract: The present invention relates to a polypeptide X1X2-RK-X3X4-KK-X5X6X7X8X9X10-KR-X11X12 SEQ ID NO: 1 able to bind selectively to cells expressing proteoglycans comprising glycosaminoglycans as heparin or heparan sulfate. The linkage of said polypeptide to an internalization peptide enables the polypeptide to be internalized. The present invention further relates to a conjugated polypeptide comprising said polypeptide and a biomarker, to a cell penetrating polypeptide comprising said polypeptide, optionally a linker and a cell internalization peptide and a chimeric polypeptide comprising said cell penetrating polypeptide and one or more biological cargos.
    Type: Application
    Filed: December 17, 2020
    Publication date: February 15, 2024
    Applicants: SORBONNE UNIVERSITE, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, ECOLE NORMALE SUPERIEURE, INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM), COLLEGE DE FRANCE
    Inventors: Sandrine Sagan, Alain Joliot, Astrid Walrant, Ludovic Carlier, Sébastien Cardon
  • Carrier vectors through an epithelium with tight junctions
    Patent number: 8242088
    Abstract: The invention concerns peptide vectors, comprising a transduction domain, and a nuclear export sequence, for carrying a molecule of interest through an epithelium with tight junctions, such as the blood-brain barrier.
    Type: Grant
    Filed: November 20, 2001
    Date of Patent: August 14, 2012
    Assignee: Centre National de la Recherche Scientifique
    Inventors: Alain Joliot, Edmond Dupont, Alain Prochiantz
  • Composition for intracellular transport of biological particles or macromolecules
    Publication number: 20070054401
    Abstract: The invention relates to a composition comprising a macromolecule or particle having one or several hydrophobic domains on the surface thereof whereby at least one transducer peptide is adsorbed thereon. Said composition can be used to introduce the macromolecule or particle into living cells.
    Type: Application
    Filed: December 31, 2003
    Publication date: March 8, 2007
    Applicants: Centre National De La Recherche Scientifique, Ecole Normale Superieure
    Inventors: Alain Prochiantz, Edmond Dupont, Alain Joliot, Alain Trembleau, Michel Volovitch
  • Carrier vectors through an epithelium with tight junctions
    Publication number: 20040029281
    Abstract: The invention concerns peptide vectors, comprising a transduction domain, and a nuclear export sequence, for carrying a molecule of interest through an epithelium with tight junctions, such as the blood-brain barrier.
    Type: Application
    Filed: May 20, 2003
    Publication date: February 12, 2004
    Inventors: Alain Joliot, Edmond Dupont, Alain Prochiantz
  • Neurotropic growth factors comprising a homeobox peptide
    Patent number: 5888762
    Abstract: The invention relates to a method for introducing a macromolecule comprising at least the helix 3 of a homeobox peptide into a living cell. In particular the macromolecule is active as a cell growth factor, in particular a neurotrope.
    Type: Grant
    Filed: May 5, 1994
    Date of Patent: March 30, 1999
    Assignee: Centre National De La Recherche Scientifique (CNRS)
    Inventors: Alain Joliot, Alain Prochiantz