Patents by Inventor Alain Jouquey
Alain Jouquey has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 4865767Abstract: Novel radioactive steroids labelled with tritium of the formula ##STR1## wherein .sup.3 H is tritium and R and R.sub.1 are individually selected from the group consisting of hydrogen, alkyl of 1 to 6 carbon atoms and acyl of an organic carboxylic acid of 1 to 10 carbon atoms useful for revealing receptors of glucocorticoids and in determining the number of fixation sites of glucocorticoids and novel intermediates.Type: GrantFiled: December 19, 1985Date of Patent: September 12, 1989Assignee: Roussel UclafInventors: Alain Jouquey, Daniel Philibert, Martine Moguilewsky, Jean-Noel Veltz
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Patent number: 4664850Abstract: Novel radioactive steriods labelled with tritium of the formula ##STR1## wherein .sup.3 H is tritium and R and R.sub.1 are individually selected from the group consisting of hydrogen, alkyl of 1 to 6 carbon atoms and acyl of an organic carboxylic acid of 1 to 10 carbon atoms useful for revealing receptors of glucocorticoids and in determining the number of fixation sites on glucocorticoids and novel intermediates.Type: GrantFiled: June 14, 1984Date of Patent: May 12, 1987Assignee: Roussel UclafInventors: Alain Jouquey, Daniel Philibert, Martine Moguilewsky, Jean-Noel Veltz
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Patent number: 4661295Abstract: Novel radioactive estradienes labelled with tritium of the formula ##STR1## wherein .sup.3 H is tritium and R is selected from the group consisting of hydrogen, alkyl of 1 to 6 carbon atoms and acyl of an organic carboxylic acid of 1 to 10 carbon atoms and the study and radioimmunological determination of non-radioactive 11.beta.-(4-dimethylaminophenyl)-17.alpha.-(prop-1-ynyl)-.DELTA..sup.4,9 -estradiene-17.beta.-ol-3-one and its metabolites in biological fluids and novel intermediates.Type: GrantFiled: June 14, 1984Date of Patent: April 28, 1987Assignee: Roussel UclafInventors: Alain Jouquey, Jean-Noel Veltz, Jean Salmon, Michel Mouren
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Patent number: 4639336Abstract: Novel radioactive estradienes labelled with iodine of the formula ##STR1## in the form of their syn or anti isomers or mixtures thereof wherein the wavy line indicates anti or syn position, R is selected from the group consisting of hydrogen, alkyl of 1 to 6 carbon atoms and acyl of an organic carboxylic acid of 1 to 12 carbon atoms and R.sub.1 is the residue of an amino acid R.sub.1 NH.sub.2 possessing an iodine acceptor group or a derivative thereof labelled with iodine .sup.125 or .sup.131 and their preparation and novel intermediates, antigens prepared from the compounds of formula I and bovine seric albumin or human seric albumin and their preparation and their use for the preparation of antibodies.Type: GrantFiled: June 14, 1984Date of Patent: January 27, 1987Assignee: Roussel UclafInventors: Alain Jouquey, Jean Salmon, Michel Mouren, Gaetan Touyer
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Patent number: 4632820Abstract: Novel radioactive .DELTA..sup.4,9,11 -estratrienes marked with iodine 125 or 131 having the formula ##STR1## wherein R is selected from the group consisting of hydrogen, alkyl of 1 to 6 carbon atoms and acyl of an organic carboxylic acid of 2 to 12 carbon atoms, R.sub.1 is the reminder of an amino acid of the formula R.sub.1 NH.sub.2 or a derivative thereof being marked with iodine 125 or 131 and the wavy lines indicate the --OR is in the .alpha.- or .beta.-position and the oximido group is in the syn or anti position, a process and intermediates for their preparation, antigens prepared therefrom and use thereof to prepare antibodies.Type: GrantFiled: December 12, 1983Date of Patent: December 30, 1986Assignee: Roussel UclafInventors: Alain Jouquey, Gaetan Touyer, Jean Salmon, Michel Mouren
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Patent number: 4591461Abstract: A novel process for the preparation of a 16-imino-17-aza-steroid of the formula ##STR1## wherein A is selected from the group consisting of hydrogen and tritium comprising reacting a compound of the formula ##STR2## wherein A has the above definition and R is an acyl of an organic carboxylic acid of 1 to 8 carbon atoms with an oximation agent to obtain a compound of the formula ##STR3## reacting the latter with an agent to form an acid chloride to obtain a compound of the formula ##STR4## reacting the latter with ammonia to obtain a compound of the formula ##STR5## reacting the latter with an alkali metal hypohalite in the presence of a base to obtain a compound of the formula ##STR6## wherein X is a halogen and reacting the latter with a base to obtain the desired compound and the novel compound of formula I wherein A is tritium and the novel intermediates of formulae III, IV, V and VI.Type: GrantFiled: October 28, 1985Date of Patent: May 27, 1986Assignee: Roussel UclafInventors: Alain Jouquey, Peter F. Hunt
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Patent number: 4565876Abstract: A novel process for the preparation of a 16-imino-17-aza-steroid of the formula ##STR1## wherein A is selected from the group consisting of hydrogen and tritium comprising reacting a compound of the formula ##STR2## wherein A has the above definition and R is an acyl of an organic carboxylic acid of 1 to 8 carbon atoms with an oximation agent to obtain a compound of the formula ##STR3## reacting the latter with an agent to form an acid chloride to obtain a compound of the formula ##STR4## reacting the latter with ammonia to obtain a compound of the formula ##STR5## reacting the latter with an alkali metal hypohalite in the presence of a base to obtain a compound of the formula ##STR6## wherein X is a halogen and reacting the latter with a base to obtain the desired compound and the novel compound of formula I wherein A is tritium and the novel intermediates of formulae III, IV, V and VI.Type: GrantFiled: May 21, 1984Date of Patent: January 21, 1986Assignee: Roussel UclafInventors: Alain Jouquey, Peter F. Hunt
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Patent number: 4529713Abstract: Novel radioactive stilbene derivatives marked with iodine 125 or 131 of the formula ##STR1## wherein each A and B are both hydrogen or together form a double bond and R is the remainder of amino acid of the formula R--NH.sub.2 or a derivative thereof possessing an iodine acceptor group and marked with iodine 125 or 131 and their preparation and antigens obtained therefrom and a process for preparing said antigens.Type: GrantFiled: June 22, 1982Date of Patent: July 16, 1985Assignee: Roussel UclafInventors: Alain Jouquey, Gaetan Touyer
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Patent number: 4191697Abstract: Novel .DELTA..sup.1,3,5(10),6 -estratetraenes of the formula ##STR1## R is selected from the group consisting of hydrogen, acyl of an alkanoic acid of 1 to 5 carbon atoms, optionally substituted benzoyl, tetrahydropyranyl, trityl and trimethylsilyl and R.sub.1 is selected from the group consisting of acyl of an alkanoic acid of 1 to 5 carbon atoms, optionally substituted benzoyl, tetrahydropyranyl, trityl and trimethylsilyl, novel intermediates therefore, process for the preparation of estradiols marked with a tritium atom and the novel tritiated estradiols which are useful to the study and dosage of specific receptors of estrogen.Type: GrantFiled: June 15, 1978Date of Patent: March 4, 1980Assignee: Roussel UclafInventors: Alain Jouquey, Jean-Pierre Raynaud, Jean Salmon
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Patent number: 4165326Abstract: Steroids of the formula ##STR1## wherein R is selected from the group consisting of hydrogen, alkyl of 1 to 4 carbon atoms, tetrahydropyranyl, trityl and trimethylsilyl, R.sub.1 is selected from the group consisting of hydrogen, acryl of an alkanoic acid of 1 to 5 carbon atoms and tetrahyropyranyl and the wavy line indicates that the OR.sub.1 group may be in either position about the carbon atom and a process and intermediates for their preparation which compounds are useful as intermediates to form novel tritium compounds of the formula ##STR2## wherein R and R.sub.1 have the above definition which are useful as intermediates for the production of (6,7-H.sup.3) 17.alpha.,21-dimethyl-19-nor-.DELTA..sup.4,9 -pregnadiene-3,20-dione.Type: GrantFiled: March 30, 1978Date of Patent: August 21, 1979Assignee: Roussel UclafInventors: Roland Bardoneschi, Alain Jouquey, Daniel Philibert
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Patent number: 4152325Abstract: Novel pregnatetraenes of the formula ##STR1## wherein R is selected from the group consisting of hydrogen, alkyl of 1 to 4 carbon atoms, tetrahydropyranyl, trityl and trimethylsilyl and intermediates therefore and a process for their preparation and a process for the preparation of tritium labelled steroids.Type: GrantFiled: November 28, 1977Date of Patent: May 1, 1979Assignee: Roussel UclafInventors: Alain Jouquey, Andre Pierdet