Patents by Inventor Alain Martel

Alain Martel has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 5945561
    Abstract: Certain novel substituted (5,6)-dihydroanthracenyl compounds of the general formula ##STR1## wherein A, n, p, R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, R.sub.6, R.sub.7 and R.sub.8 are as defined in the specification exhibit retinoid-like properties and are particularly useful in the prevention of post-surgical adhesions.
    Type: Grant
    Filed: April 24, 1998
    Date of Patent: August 31, 1999
    Assignee: Bristol-Myers Squibb Company
    Inventors: John E. Starrett, Jr., Kenneth M. Tramposch, Xina Nair, Peter R. Reczek, Anna Ericsson, Anne Marinier, Alain Martel, Fred C. Zusi
  • Patent number: 5747463
    Abstract: There is provided a novel series of malonate derivatives of glycolipid compounds of the formula ##STR1## wherein R is an acyl residue of a fatty acid:R.sup.1 is --(CH.dbd.CH).sub.m --(CH.sub.2).sub.n --CH.sub.3 ;R.sup.2, R.sup.3, R.sup.4, R.sup.5 and R.sup.6 each are independently hydrogen, unsubstituted or substituted (lower)alkanoyl, arylalkyl or arylcarbonyl wherein said substituent is selected from the group consisting of halogen, C.sub.1-4 alkyl, trifluoromethyl, hydroxy and C.sub.1-4 alkoxy provided that one of R.sup.2, R.sup.3, R.sup.4 and R.sup.6 substituents is --(CH.sub.2).sub.p --CH(CO.sub.2 R.sup.7).sub.2 ;m is an integer of 0 or 1;n is an integer of from 5 to 14 inclusive;p is an integer of from 2 to 6 inclusive; andR.sup.
    Type: Grant
    Filed: October 2, 1996
    Date of Patent: May 5, 1998
    Assignee: Bristol-Myers Squibb Company
    Inventors: Anne Marinier, Alain Martel
  • Patent number: 5686426
    Abstract: There is provided a novel series of O-carboxymethylated .alpha.- and .beta.-glycolipid compounds of the formula ##STR1## wherein R is an acyl residue of a fatty acid;R.sup.1 is --(CH.dbd.CH).sub.m --(CH.sub.2).sub.n --CH.sub.3 ;R.sup.2, R.sup.3, R.sup.4 R.sup.5 and R.sup.6 each are independently hydrogen, unsubstituted or substituted alkanoyl, arylalkyl or arylcarbonyl wherein said substituent is selected from halogen, C.sub.1-4 alkyl, trifluoromethyl, hydroxy and C.sub.1-4 alkoxy;R.sup.3, R.sup.4 and R.sup.6 each are independently --CH.sub.2 COOR.sup.7, provided at least two of the R.sup.3, R.sup.4 and R.sup.6 substituents are --CH.sub.2 COOR.sub.7 ;m is an integer of 0 or 1;n is an integer of from 5 to 14, inclusive; andR.sup.
    Type: Grant
    Filed: November 17, 1994
    Date of Patent: November 11, 1997
    Assignee: Bristol-Myers Squibb Company
    Inventors: Alain Martel, John J. Wright
  • Patent number: 5672701
    Abstract: Compounds of the formula ##STR1## wherein A is an unsubstituted or hydroxy-substituted straight or branched C.sub.1-10 alkylene group or a straight or branched C.sub.1-10 alkylene group having an intervening heteroatom selected from oxygen, sulfur and nitrogen;R.sup.2 is hydroxy, halogen, C.sub.1-4 alkoxy, nitrile, azido, a quaternary ammonio group, --NR.sup.5 R.sup.6, ##STR2## azetidinyl, or a 5- or 6-membered heterocyclic group selected from heteroaromatic and heteroalicyclic joined through a carbon atom thereof;or a non-toxic pharmaceutically acceptable salt thereof, are novel antimicrobial agents which are useful in the treatment of infectious disease in humans and other animals. Novel intermediates and processes for their preparation are also disclosed.
    Type: Grant
    Filed: January 26, 1995
    Date of Patent: September 30, 1997
    Assignee: Bristol-Myers Squibb Company
    Inventors: Alain Martel, Carol Bachand, Marcel Menard
  • Patent number: 5663151
    Abstract: There is provided novel sulfated .alpha.-glycolipid compounds of the formula ##STR1## wherein R is an acyl residue of a fatty acid;R.sup.1 is --(CH.dbd.CH).sub.m --(CH.sub.2).sub.n --CH.sub.3 ;R.sup.2, R.sup.3, R.sup.4and R.sup.6 are independently at least two --SO.sub.3 H;R.sup.2, R.sup.3, R.sup.4R.sup.5 and R.sup.6 each are independently hydrogen, unsubstituted or substituted alkanoyl, arylalkyl or arylcarbonyl wherein said substituent is selected from halogen, C.sub.1-4 alkyl, trifluoromethyl, hydroxy and C.sub.1-4 alkoxy;m is an integer of 0 or 1;n is an integer of from 5 to 14, inclusive;or a non-toxic pharmaceutically acceptable salt, solvate or hydrate thereof which are inhibitors of selectin-mediated cellular adhesion and are useful in the treatment or prevention of inflammatory diseases and other pathological conditions in mammals.
    Type: Grant
    Filed: January 27, 1995
    Date of Patent: September 2, 1997
    Assignee: Bristol-Myers Squibb Company
    Inventors: Alain Martel, Jacques Banville, Alejandro A. Aruffo
  • Patent number: 5565433
    Abstract: There is provided novel sulfated p-glycolipid compounds of the formula ##STR1## wherein R is an acyl residue of a fatty acid;R.sup.1 is --(CH.dbd.CH).sub.m --(CH.sub.2).sub.n --CH.sub.3 ;R.sup.2, R.sup.3, R.sup.4 and R.sup.6 each are independently --SO.sub.3 H, hydrogen, unsubstituted or substituted alkanoyl, arylalkyl or arylcarbonyl wherein said substituent is selected from the group consisting of halogen, C.sub.1-4 alkyl, trifluoromethyl, hydroxy and C.sub.1-4 alkoxy; or R.sub.4 and R.sub.6, taken together are isopropylidene; provided at least two of R.sup.2, R.sup.3, R.sup.4 and R.sup.6 are --SO.sub.3 H;R.sup.5 is hydrogen, unsubstituted or substituted alkanoyl, arylalkyl or arylcarbonyl wherein said substituent is selected from the group consisting of halogen, C.sub.1-4 alkyl, trifluoromethyl, hydroxy and C.sub.
    Type: Grant
    Filed: February 12, 1996
    Date of Patent: October 15, 1996
    Assignee: Bristol-Myers Squibb Company
    Inventors: Jacques Banville, Alain Martel, Alejandro A. Aruffo
  • Patent number: 5070399
    Abstract: A color and intensity modulation system has an output to be connected to a color light projector and an input to receive a hue control signal and an intensity control signal including at least one modulation frequency component F. The system comprises a color scaling device, receiving in use the hue signal, the color scaling device producing a plurality of color component signals, the plurality of color component signals being supplied as the output to the color light projector, and an intensity control device, receiving in use the intensity control signal, the intensity control device comprising a low frequency oscillator whose output is an intensity modulation signal for varying an intensity of the plurality of color component signals between a preset minimum and a preset maximum value, the oscillator having a frequency responsive to the at least one modulation frequency component F of the intensity control signal, the plurality of color component signals to control in use the projector.
    Type: Grant
    Filed: December 21, 1990
    Date of Patent: December 3, 1991
    Inventor: Alain Martel
  • Patent number: 4895939
    Abstract: Disclosed herein is a novel high .beta.-yield producing novel intermediates of the formula ##STR1## where R.sup.4 is ##STR2## useful in the synthesis of 1-.beta.-alkyl carbapenems.
    Type: Grant
    Filed: June 14, 1988
    Date of Patent: January 23, 1990
    Assignee: Bristol-Myers Company
    Inventors: Alain Martel, Jean-Paul Daris, Jacques Corbeil
  • Patent number: 4772683
    Abstract: Disclosed herein is a novel process using novel silyl enol ether intermediates of the formula ##STR1## to generate novel azetidione thiolester intermediates of the formula ##STR2## which can be used to form 1-.beta.-alkyl carbapenem antibiotics. It has now been discovered that if the R.sup.4 group is selected from a small group of moieties having the formula: ##STR3## an increased .beta.-yield of up to approximately 100% can be obtained.
    Type: Grant
    Filed: February 24, 1986
    Date of Patent: September 20, 1988
    Assignee: Bristol-Myers Company
    Inventors: Alain Martel, Jean-Paul Daris, Jacques Corbeil
  • Patent number: 4665169
    Abstract: Novel carbapenem antibiotics are prepared in which the 2-substituent has the formula ##STR1## wherein n is 0, 1, 2, 3, m, is 1 or 2, and R is C.sub.1 -C.sub.6 alkyl, allyl, propargyl, carboxymethyl, cyanomethyl or aralkyl wherein the aryl moiety is phenyl or heteroaryl and the alkyl moiety is C.sub.1 -C.sub.6 alkyl, said heterocyclic ring containing the sulfonium group being optionally substituted at a ring carbon atom or atoms by one or two C.sub.1 -C.sub.6 alkyl groups.
    Type: Grant
    Filed: September 11, 1985
    Date of Patent: May 12, 1987
    Assignee: Bristol-Myers Company
    Inventors: Alain Martel, Carol Bachand
  • Patent number: 4639335
    Abstract: A novel stereocontrolled process is disclosed for converting 6-aminopenicillanic acid to an optically active azetidinone of the formula ##STR1## wherein R" is a hydroxy-protecting group by use of a 6,6-dihaloanhydropenicillin or 6,6-bis(phenylselenyl)anhydropenicillin intermediate.
    Type: Grant
    Filed: January 13, 1986
    Date of Patent: January 27, 1987
    Assignee: Bristol-Myers Company
    Inventors: Alain Martel, Jean-Paul Daris
  • Patent number: 4596677
    Abstract: A novel stereocontrolled process is disclosed for converting 6-aminopenicillanic acid to an optically active azetidinone of the formula ##STR1## wherein R" is a hydroxy-protecting group by use of a 6,6-dihaloanhydropenicillin or 6,6-bis(phenylselenyl)anhydropenicillin intermediate.
    Type: Grant
    Filed: April 6, 1984
    Date of Patent: June 24, 1986
    Assignee: Bristol-Myers Company
    Inventors: Alain Martel, Jean-Paul Daris
  • Patent number: 4461727
    Abstract: This invention relates to 2-substituted and 2,6-disubstituted penem compounds of the formula ##STR1## wherein Y is hydrogen, halo or certain organic radicals and X represents certain hetero-interrupted substituted alkyl radicals. Also included in the invention are pharmaceutically acceptable salts of the above compounds and derivatives of the above compounds in which the carboxyl group at the 3-position is protected as by an easily removable ester protecting group. The compounds of the present invention are potent antibacterial agents or are of use as intermediates in the preparation of such agents.
    Type: Grant
    Filed: September 10, 1982
    Date of Patent: July 24, 1984
    Assignee: Bristol-Myers Company
    Inventors: Marcel Menard, Alain Martel
  • Patent number: 4406834
    Abstract: This invention relates to 2-substituted and 2,6-disubstituted penem compounds of the formula ##STR1## wherein Y is hydrogen, halo or certain organic radicals and X represents certain hetero-interrupted substituted alkyl radicals. Also included in the invention are pharmaceutically acceptable salts of the above compounds and derivatives of the above compounds in which the carboxyl group at the 3-position is protected as by an easily removable ester protecting group. The compounds of the present invention are potent antibacterial agents or are of use as intermediates in the preparation of such agents.
    Type: Grant
    Filed: April 13, 1981
    Date of Patent: September 27, 1983
    Assignee: Bristol-Myers Company
    Inventors: Marcel Menard, Alain Martel
  • Patent number: 4378314
    Abstract: This invention relates to 2-substituted and 2,6-disubstituted penem compounds of the formula ##STR1## wherein Y is hydrogen, halo or certain organic substituents and X represents certain organic substituents. Also included in the invention are pharmaceutically acceptable salts of the above compounds and derivatives of the above compounds in which the carboxyl group at the 3-position is protected as by an easily removable ester protecting group. The compounds of the present invention are potent antibacterial agents or are of use as intermediates in the preparation of such agents.
    Type: Grant
    Filed: October 24, 1980
    Date of Patent: March 29, 1983
    Assignee: Bristol Myers Company
    Inventors: Marcel Menard, Alain Martel
  • Patent number: 4374065
    Abstract: This invention relates to 2-substituted and 2,6-disubstituted penem compounds of the formula ##STR1## wherein Y is hydrogen, halo or certain organic radicals and X represents certain hereto-interrupted substituted alkyl radicals. Also included in the invention are pharmaceutically acceptable salts of the above compounds and derivatives of the above compounds in which the carboxyl group at the 3-position is protected as by an easily removable ester protecting group. The compounds of the present invention are potent antibacterial agents or are of use as intermediates in the preparation of such agents.
    Type: Grant
    Filed: April 13, 1981
    Date of Patent: February 15, 1983
    Assignee: Bristol-Myers Company
    Inventors: Marcel Menard, Alain Martel
  • Patent number: 4282150
    Abstract: This invention relates to 2-substituted and 2,6-disubstituted penem compounds of the formula ##STR1## wherein Y is hydrogen, halo or certain organic radicals and X represents certain hetero-interrupted substituted alkyl radicals. Also included in the invention are pharmaceutically acceptable salts of the above compounds and derivatives of the above compounds in which the carboxyl group at the 3-position is protected as by an easily removable ester protecting group. The compounds of the present invention are potent antibacterial agents or are of use as intermediates in the preparation of such agents.
    Type: Grant
    Filed: September 21, 1979
    Date of Patent: August 4, 1981
    Assignee: Bristol-Myers Company
    Inventors: Marcel Menard, Alain Martel
  • Patent number: 4272437
    Abstract: This invention relates to 2-substituted and 2,6-disubstituted penem compounds of the formula ##STR1## wherein Y is hydrogen, halo or certain organic substituents and X represents certain organic substituents. Also included in the invention are pharmaceutically acceptable salts of the above compounds and derivatives of the above compounds in which the carboxyl group at the 3-position is protected as by an easily removable ester protecting group. The compounds of the present invention are potent antibacterial agents or are of use as intermediates in the preparation of such agents.
    Type: Grant
    Filed: September 21, 1979
    Date of Patent: June 9, 1981
    Assignee: Bristol-Myers Company
    Inventors: Marcel Menard, Alain Martel