Patents by Inventor Alain Moreau

Alain Moreau has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10620222
    Abstract: Methods for diagnosing a predisposition to developing a scoliosis (e.g., adolescent idiopathic scoliosis (AIS)) and identifying compounds for treating scoliosis based on the modulation of Gi protein-coupled receptor activity are described. Specific embodiments of the methods involve measuring a change in impedance signals of cells expressing a receptor coupled to a Gi protein with a ligand. To identify compounds useful in treatment, the cell is contacted with a test compound and a ligand. A higher impedance in the presence relative to the absence of said test compound is indicative that the test compound is useful for treating scoliosis.
    Type: Grant
    Filed: July 20, 2015
    Date of Patent: April 14, 2020
    Assignee: CHU Sainte-Justine
    Inventors: Alain Moreau, Marie-Yvonne Akoume Ndong
  • Publication number: 20190195859
    Abstract: Disclosed herein are novel molecular markers associated with idiopathic scoliosis (IS). Accordingly, the present invention concerns novel methods of identifying subjects at risk of developing IS or suffering from IS and of genotyping and classifying IS subjects into genetic and functional groups. Also provided are compositions, DNA chips and kits for applying the methods.
    Type: Application
    Filed: August 23, 2017
    Publication date: June 27, 2019
    Applicant: CHU Sainte-Justine
    Inventors: Alain Moreau, Niaz Oliazadeh, Kristen Fay Gorman, Robert Eveleigh, Guillaume Bourque
  • Publication number: 20190190266
    Abstract: A power control device for use in an AC power grid for regulating an electrical power a load that is supplied by the AC power grid consumes. The power control device has a frequency sensing functional block for detecting a deviation of the grid frequency from a nominal grid frequency and a logic functional block for performing a load adjustment process during which the power the load consumption is reduced. The load adjustment process is based at least in part on the variation of the frequency of the AC power grid. The load adjustment process is design such that for a plurality of power control devices the individual response produce a grid-wide effect that compensates imbalance between power generation and load in fashion that may reduce unwanted distortion in the AC power grid, such as flicker.
    Type: Application
    Filed: May 10, 2017
    Publication date: June 20, 2019
    Inventors: SYLVAIN SOULIERES, SIMON JASMIN, FRANCOIS LAURENCELLE, ALAIN MOREAU, CLAUDE VILLEMURE, STEPHANE BOYER
  • Patent number: 10324095
    Abstract: A method of predicting the risk of developing osteoarthritis (OA) comprising: (a) measuring the nuclear cellular level of prohibitin (PHB-1) in nucleated cells present in a blood sample from a subject having or suspected of having OA; and (b) comparing said nuclear cellular level to that corresponding to a control sample; and (c) identifying the subject as being at risk of developing OA when the nuclear cellular level of said PHB-1 in said blood sample is higher than in the control sample; and a composition for determining the risk of developing osteoarthritis (OA), said composition comprising: a cell sample from a subject; and a non-naturally occurring molecule for detecting nuclear accumulation of PHB1.
    Type: Grant
    Filed: May 19, 2016
    Date of Patent: June 18, 2019
    Assignee: VALORISATION HSJ, LIMITED PARTNERSHIP
    Inventor: Alain Moreau
  • Publication number: 20190178896
    Abstract: A method of classifying a subject having idiopathic scoliosis (IS) or at risk of developing IS comprising: determining the cellular response to Gi stimulation in a cell sample from the subject in the presence of OPN; determining the cellular response to Gi stimulation in a cell sample from the subject in the absence of OPN; and comparing the cellular response obtained in the presence of OPN with the cellular response obtained in the absence of OPN, whereby the comparing step enables the classification of the subject into one IS functional group. Also provided is the use of the foregoing method to classify borderline subjects and kits for applying the methods.
    Type: Application
    Filed: February 15, 2019
    Publication date: June 13, 2019
    Applicant: Chu Sainte-Justine
    Inventors: Alain Moreau, Marie - Yvonne Akoume Ndong
  • Patent number: 10247737
    Abstract: A method of classifying a subject having idiopathic scoliosis (IS) or at risk of developing IS comprising: determining the cellular response to Gi stimulation in a cell sample from the subject in the presence of OPN; determining the cellular response to Gi stimulation in a cell sample from the subject in the absence of OPN; and comparing the cellular response obtained in the presence of OPN with the cellular response obtained in the absence of OPN, whereby the comparing step enables the classification of the subject into one IS functional group. Also provided is the use of the foregoing method to classify borderline subjects and kits for applying the methods.
    Type: Grant
    Filed: September 9, 2014
    Date of Patent: April 2, 2019
    Assignee: Chu Sainte-Justine
    Inventors: Alain Moreau, Marie-Yvonne Akoume Ndong
  • Publication number: 20180284132
    Abstract: Kits for stratifying a subject having or at risk for developing adolescent idiopathic scoliosis (AIS) into diagnostically or clinically useful subclasses are provided. The stratification is based on the subject's Gi? protein serine phosphorylation profile and/or the degree of imbalance in G-protein coupled receptor responses to Gi? and Gs? protein stimulation. In some embodiments, the methods involve detecting or determining the level of serine phosphorylated Gi?1 and/or Gi?3 proteins in the cell sample, and/or determining a ratio between the response to Gi? protein stimulation and the response to Gs? protein stimulation from a biological sample from the subject. Kits for predicting the risk of an AIS subject for developing a severe scoliosis, for predicting the subject's responsiveness to bracing treatment, and for identifying therapeutically useful compounds are also provided.
    Type: Application
    Filed: April 24, 2018
    Publication date: October 4, 2018
    Inventors: Alain MOREAU, Marie-Yvonne AKOUME NDONG
  • Patent number: 10073101
    Abstract: A method for the prevention or treatment of scoliosis in a human subject comprising: (a)(i) measuring osteopontin (OPN) protein expression in a biological fluid sample from the subject over time; or (ii) measuring osteopontin (OPN) protein expression in a biological fluid sample from the subject and comparing the OPN protein expression to an OPN protein expression in a control biological fluid sample; (b) identifying the subject as being at risk of developing scoliosis when OPN protein expression increases in the subject sample over time; or when OPN protein expression is higher in the subject sample than that in the control sample; and (c) reducing OPN protein levels in the subject identified as being at risk of developing a scoliosis, thereby aiding in the prevention or treatment of scoliosis.
    Type: Grant
    Filed: July 23, 2015
    Date of Patent: September 11, 2018
    Assignee: CHU SAINTE-JUSTINE
    Inventor: Alain Moreau
  • Publication number: 20180224467
    Abstract: The present invention provides a method of treating a subject in need thereof comprising classifying the subject into functional group FG1, FG2 or FG3, wherein i) when the subject is classified into the FG1 functional group, (A) the level of OPN or the activity of OPN in said subject is increased; (B) the subject is not treated with a brace; or (C) a combination of (A) and (B); and ii) when the subject is classified into the FG2 or FG3 functional group, (A) the level of OPN or the activity of OPN in said subject is decreased; (B) the subject is treated with a brace; or (C) a combination of (A) and (B).
    Type: Application
    Filed: March 2, 2018
    Publication date: August 9, 2018
    Inventors: Alain Moreau, Marie - Yvonne Akoume Ndong
  • Publication number: 20180171015
    Abstract: Disclosed herein are methods of determining the risk of developing a scoliosis based on the presence of at least one copy of a CD44 risk allele; methods of stratifying a subject having a scoliosis; methods of treating subjects having a scoliosis and compositions and kits for performing these methods.
    Type: Application
    Filed: January 24, 2018
    Publication date: June 21, 2018
    Inventors: Alain Moreau, Marie-Yvonne Akoume Ndong
  • Patent number: 9989531
    Abstract: Methods of stratifying a subject having or at risk for developing adolescent idiopathic scoliosis (AIS) into diagnostically or clinically useful subclasses are provided. The stratification is based on the subject's PTP? expression and/or activity and/or PIPK1? expression and/or activity. Also provided are methods of predicting the risk of developing a scoliosis also based on the subject's PTP? expression and/or activity and/or PIPK1? expression and/or activity; and methods of increasing GiPCR signaling in cells of a subject in need thereof comprising administering to the subject's cells an effective amount of an inhibitor of PIPK1? tyrosine phosphorylation; an activator of PIPK1Y tyrosine dephosphorylation; and/or an inhibitor of PIPK1? expression and/or activity.
    Type: Grant
    Filed: June 17, 2014
    Date of Patent: June 5, 2018
    Assignee: Chu Sainte-Justine
    Inventors: Alain Moreau, Marie-Yvonne Akoume Ndong, Mohamed Elbakry
  • Publication number: 20160368992
    Abstract: There is provided a method of increasing GIPCR signalization in the cells of a subject in need thereof comprising administering to the subject an effective amount of an inhibitor of integrin alpha5beta1 expression and/or activity, whereby GiPCR signalization is increased in the cells of the subject. An inhibitor of integrin alph5beta1 may be, for example, an agent that inhibits the interaction between f osteopontin (OPN) and integrin alpha5beta1. Also provided are methods of determining the risk of developing a scoliosis and based on the presence of at least one copy of a CD44 risk allele and methods of stratifying a subject having a scoliosis and kits for performing these methods. In particular, the method of determining risk identifies SNP rs1467558; an isoleucine to threonine mutation at position 230 of CD44.
    Type: Application
    Filed: June 17, 2014
    Publication date: December 22, 2016
    Inventors: Alain Moreau, Marie-Yvonne Akoume Ndong
  • Publication number: 20160299155
    Abstract: A method of predicting the risk of developing osteoarthritis (OA) comprising: (a) measuring the nuclear cellular level of prohibitin (PHB-1) in nucleated cells present in a blood sample from a subject having or suspected of having OA; and (b) comparing said nuclear cellular level to that corresponding to a control sample; and (c) identifying the subject as being at risk of developing OA when the nuclear cellular level of said PHB-1 in said blood sample is higher than in the control sample; and a composition for determining the risk of developing osteoarthritis (OA), said composition comprising: a cell sample from a subject; and a non-naturally occurring molecule for detecting nuclear accumulation of PHB1.
    Type: Application
    Filed: May 19, 2016
    Publication date: October 13, 2016
    Inventor: ALAIN MOREAU
  • Publication number: 20160291016
    Abstract: Methods of stratifying a subject having or at risk for developing adolescent idiopathic scoliosis (AIS) into diagnostically or clinically useful subclasses are provided. The stratification is based on the subject's PTP? expression and/or activity and/or PIPK1? expression and/or activity. Also provided are methods of predicting the risk of developing a scoliosis also based on the subject's PTP? expression and/or activity and/or PIPK1? expression and/or activity; and methods of increasing GiPCR signaling in cells of a subject in need thereof comprising administering to the subject's cells an effective amount of an inhibitor of PIPK1? tyrosine phosphorylation; an activator of PIPK1Y tyrosine dephosphorylation; and/or an inhibitor of PIPK1? expression and/or activity.
    Type: Application
    Filed: June 17, 2014
    Publication date: October 6, 2016
    Applicant: Chu Sainte-Justine
    Inventors: Alain Moreau, Marie - Yvonne Akoume Ndong, Mohamed Elbakry
  • Publication number: 20160258947
    Abstract: A composition for classifying a human pediatric subject having adolescent idiopathic scoliosis (AIS), comprising (a) a cell sample of the subject; and (b) a known melatonin-signaling pathway agonist, wherein said melatonin signaling pathway in said cell sample has been artificially induced by said melatonin-signaling pathway agonist, wherein the cell sample is selected from the group consisting of blood cell sample, osteoblast cell sample, osteoclast cell sample and myoblast cell sample, and whereby the composition enables the detection of the presence or absence of at least one impairment in the melatonin-signaling pathway in cells from said cell sample and thereby enables the classification of subject.
    Type: Application
    Filed: May 19, 2016
    Publication date: September 8, 2016
    Inventor: ALAIN MOREAU
  • Publication number: 20160223570
    Abstract: A method of determining whether a subject is at risk of developing osteoarthritis (OA), said method comprising: determining the cellular localization of a Prohibitin-1 (PHB1) polypeptide and/or Small Ubiquitin-like Modifier (SUMO) polypeptide and/or UBC9, in a cell sample from said subject; and determining whether said subject is at risk of developing OA based on the cellular localization of a PHB1 polypeptide and/or SUMO and/or UBC9 polypeptide, is described.
    Type: Application
    Filed: February 11, 2016
    Publication date: August 4, 2016
    Inventor: ALAIN MOREAU
  • Publication number: 20160223567
    Abstract: The present invention provides a method of predicting brace treatment outcome in a subject in need thereof comprising i) classifying the subject into functional group FG1, FG2 or FG3, wherein the classification enables the prediction of brace treatment outcome. Also provided are methods of determining risk of developing scoliosis, methods of treating Idiopathic scoliosis and kits for applying the methods.
    Type: Application
    Filed: September 9, 2014
    Publication date: August 4, 2016
    Applicant: Chu Sainte-Justine
    Inventors: Alain Moreau, Marie-Yvonne Akoume Ndong
  • Publication number: 20160216277
    Abstract: A method of classifying a subject having idiopathic scoliosis (IS) or at risk of developing IS comprising: determining the cellular response to Gi stimulation in a cell sample from the subject in the presence of OPN; determining the cellular response to Gi stimulation in a cell sample from the subject in the absence of OPN; and comparing the cellular response obtained in the presence of OPN with the cellular response obtained in the absence of OPN, whereby the comparing step enables the classification of the subject into one IS functional group. Also provided is the use of the foregoing method to classify borderline subjects and kits for applying the methods.
    Type: Application
    Filed: September 9, 2014
    Publication date: July 28, 2016
    Applicant: Chu Sainte-Justine
    Inventors: Alain Moreau, Marie-Yvonne Akoume Ndong
  • Publication number: 20160146839
    Abstract: Methods for diagnosing a predisposition to developing a scoliosis (e.g., adolescent idiopathic scoliosis (AIS)) and identifying compounds for treating scoliosis based on the modulation of Gi protein-coupled receptor activity are described. Specific embodiments of the methods involve measuring a change in impedance signals of cells expressing a receptor coupled to a Gi protein with a ligand. To identify compounds useful in treatment, the cell is contacted with a test compound and a ligand. A higher impedance in the presence relative to the absence of said test compound is indicative that the test compound is useful for treating scoliosis.
    Type: Application
    Filed: July 20, 2015
    Publication date: May 26, 2016
    Applicant: CHU SAINTE-JUSTINE
    Inventors: Alain Moreau, Marie-Yvonne Akoume Ndong
  • Publication number: 20160139146
    Abstract: Methods of stratifying a subject having or at risk for developing adolescent idiopathic scoliosis (AIS) into diagnostically or clinically useful subclasses are provided. The stratification is based on the subject's Gi? protein serine phosphorylation profile and/or the degree of imbalance in G-protein coupled receptor responses to Gi? and Gs? protein stimulation. In some embodiments, the methods involve detecting or determining the level of serine phosphorylated Gi?1 and/or Gi?3 proteins in the cell sample, and/or determining a ratio between the response to Gi? protein stimulation and the response to Gs? protein stimulation from a biological sample from the subject. Methods for predicting the risk of an AIS subject for developing a severe scoliosis, for predicting the subject's responsiveness to bracing treatment, and for identifying therapeutically useful compounds are also provided, as well as kits therefor.
    Type: Application
    Filed: June 16, 2014
    Publication date: May 19, 2016
    Applicant: CHU SAINTE-JUSTINE
    Inventors: Alain Moreau, Marie-Yvonne Akoume Ndong