Patents by Inventor Alain N. Nicoletta

Alain N. Nicoletta has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for determining plasma volume, determination of blood volume thereby, and apparatus therefore
    Patent number: 5685302
    Abstract: The subject invention provides a method for determining in a subject the volume of plasma in the subject's circulation which comprises introducing into the subject's circulation a predetermined amount of a pharmaceutically-acceptable solution comprising a predetermined quantity of biodegradable, nontoxic macromolecules, which macromolecules are sufficiently larger than endothelial junctions in the subject's capillaries so that they are incapable of permeating the subject's capillaries, and each of which macromolecules is labeled with a detectable marker; obtaining a sample of plasma from the subject; determining the concentration of macromolecules in the sample; and calculating the volume of liquid which would dilute the sample to the concentration so determined. The subject invention also provides a method for determining in a subject the volume of blood in the subject's circulation which comprises determining the volume of plasma in the subject's circulation according to the aforementioned method.
    Type: Grant
    Filed: November 22, 1994
    Date of Patent: November 11, 1997
    Assignee: The Trustees of Columbia University in the City of New York
    Inventors: Bashir A. Zikria, Alain N. Nicoletta