Patents by Inventor Alain Nicolas

Alain Nicolas has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11795465
    Abstract: The present invention relates to new transcriptional promoters that are functional during meiosis. It thus provides new tools, methods and compositions for the expression of proteins during meiosis in a eukaryotic cell, and more particularly in a plant cell.
    Type: Grant
    Filed: May 23, 2019
    Date of Patent: October 24, 2023
    Assignees: MEIOGENIX, INTITUT NATIONAL DE RECHERCHE POUR L'AGRICULTURE, L'ALIMENTATION ET L'ENVIRONNEMENT, UNIVERSITE CLAUDE BERNARD LYON 1, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, ECOLE NORMALE SUPERIEURE DE LYON
    Inventors: Giacomo Bastianelli, Alain Nicolas, Peter Rogowsky
  • Publication number: 20230239459
    Abstract: An imaging pixel formed by a photodetector connected to a reading circuit comprising: an integration capacitance, a transistor for resetting the integration capacitance, a coupling transistor between the photodetector and the integration capacitance, a memorisation capacitance, a second transistor for resetting the memorisation capacitance, a memorisation switch between the integration capacitance and the memorisation capacitance, to enable different configurations corresponding to different phases of assessing parameters of the pixel and in particular a ratio R=Cint/Cmem.
    Type: Application
    Filed: January 24, 2023
    Publication date: July 27, 2023
    Applicant: COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES
    Inventor: Jean-Alain NICOLAS
  • Publication number: 20230174960
    Abstract: The present invention relates to a fusion protein comprising a domain of a nuclease from the class II CRISPR system, and a Spo11 domain, wherein both domains of the fusion protein have deficient nuclease activity, as well as the use of this protein to induce targeted meiotic recombinations in a eukaryotic cell.
    Type: Application
    Filed: May 20, 2021
    Publication date: June 8, 2023
    Inventors: ALEXANDRE SERERO, ALAIN NICOLAS
  • Publication number: 20230145351
    Abstract: Imager readout circuit comprising: an active reset stage of the integration capacitor equipped with a first current amplifier, a buffered direct injection bias stage of the photodetector equipped with transistors forming a second current amplifier, a switching circuit comprising a coupling stage integrated in the readout circuit, the switching circuit being controlled by control signals and being configured to: during a reset phase of the integration capacitor corresponding to a first state of said control signals: couple said first current source to the integration capacitor and activate the first current amplifier while uncoupling said second current source of the photodetector and deactivating the second amplifier, during an integration phase of a current from the photodiode and corresponding to a second state of said control signals, couple said second current source to the photodetector and activate the second current amplifier while uncoupling said first current source of the integration capacitor an
    Type: Application
    Filed: October 31, 2022
    Publication date: May 11, 2023
    Applicant: COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES
    Inventor: Jean-Alain NICOLAS
  • Publication number: 20220162647
    Abstract: The present invention relates to a fusion protein comprising a Cas9 domain and a Spo11 domain, as well as the use of this protein to induce targeted meiotic recombinations in a eukaryotic cell.
    Type: Application
    Filed: February 14, 2022
    Publication date: May 26, 2022
    Inventors: GIACOMO BASTIANELLI, ALEXANDRE SERERO, ALAIN NICOLAS
  • Patent number: 11332218
    Abstract: An attachment of a stockless anchor on the sea floor encourages flukes to tilt as soon as the vessel pulls away, while maintaining stability on the floor. The weight of the flukes act as a pivot with the crown of the stockless anchor that, when placed on the floor, causes the anchor to become attached by being buried in the floor when the vessel pulls away. The attachment comprises two claws fastened to the flanks of the flukes at or in close proximity of the crown on the pivot axis of the flukes, thereby enabling them to tilt and become attached immediately in the floor as soon as the anchor is placed on the floor. When the vessel pulls away the anchor is open and becomes attached immediately. An attachment to the floor avoids or reduces dragging of the anchor on the floor.
    Type: Grant
    Filed: July 1, 2020
    Date of Patent: May 17, 2022
    Inventor: Alain Nicolas Maurin
  • Patent number: 11248240
    Abstract: The present invention relates to a fusion protein comprising a Cas9 domain and a Spo11 domain, as well as the use of this protein to induce targeted meiotic recombinations in a eukaryotic cell.
    Type: Grant
    Filed: January 29, 2016
    Date of Patent: February 15, 2022
    Assignees: MEIOGENIX, INSTITUT CURIE, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, SORBONNE UNIVERSITE
    Inventors: Giacomo Bastianelli, Alexandre Serero, Alain Nicolas
  • Patent number: 11240459
    Abstract: External biasing control unit for a reading circuit of an infrared photodetector element, the control unit being able to adopt: a first configuration wherein it sends a first set of biasing signals to a first stage of the reading circuit so that this first stage adopts a first operating mode corresponding to a first biasing mode of the photodetector, in particular a direct injection mode, a second configuration wherein it sends a second set of biasing signals to said first stage, the signals in the second set being designed so that said first stage adopts a second operating mode corresponding to a second biasing mode of the photodetector, in particular a buffer direct injection mode.
    Type: Grant
    Filed: October 28, 2020
    Date of Patent: February 1, 2022
    Assignee: COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES
    Inventor: Jean-Alain Nicolas
  • Publication number: 20210230619
    Abstract: The present invention relates to new transcriptional promoters that are functional during meiosis. It thus provides new tools, methods and compositions for the expression of proteins during meiosis in a eukaryotic cell, and more particularly in a plant cell.
    Type: Application
    Filed: May 23, 2019
    Publication date: July 29, 2021
    Inventors: GIACOMO BASTIANELLI, ALAIN NICOLAS, PETER ROGOWSKY
  • Publication number: 20210136306
    Abstract: External biasing control unit for a reading circuit of an infrared photodetector element, the control unit being able to adopt: a first configuration wherein it sends a first set of biasing signals to a first stage of the reading circuit so that this first stage adopts a first operating mode corresponding to a first biasing mode of the photodetector, in particular a direct injection mode, a second configuration wherein it sends a second set of biasing signals to said first stage, the signals in the second set being designed so that said first stage adopts a second operating mode corresponding to a second biasing mode of the photodetector, in particular a buffer direct injection mode.
    Type: Application
    Filed: October 28, 2020
    Publication date: May 6, 2021
    Applicant: COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES
    Inventor: Jean-Alain NICOLAS
  • Patent number: 10844367
    Abstract: The present invention relates to a method for improving an industrial yeast strain of industrial interest, particularly a sterile hybrid strain, without resorting to recombinant DNA techniques.
    Type: Grant
    Filed: November 29, 2013
    Date of Patent: November 24, 2020
    Assignees: INSTITUT CURIE, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITE PIERRE ET MARIE CURIE (PARIS 6), UNIVERSITE NICE SOPHIA ANTIPOLIS, INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE)
    Inventors: Alain Nicolas, Gianni Liti
  • Publication number: 20200361570
    Abstract: An attachment of a stockless anchor on the sea floor encourages flukes to tilt as soon as the vessel pulls away, while maintaining stability on the floor. The weight of the flukes act as a pivot with the crown of the stockless anchor that, when placed on the floor, causes the anchor to become attached by being buried in the floor when the vessel pulls away. The attachment comprises two claws fastened to the flanks of the flukes at or in close proximity of the crown on the pivot axis of the flukes, thereby enabling them to tilt and become attached immediately in the floor as soon as the anchor is placed on the floor. When the vessel pulls away the anchor is open and becomes attached immediately. An attachment to the floor avoids or reduces dragging of the anchor on the floor.
    Type: Application
    Filed: July 1, 2020
    Publication date: November 19, 2020
    Inventor: Alain Nicolas Maurin
  • Patent number: 10766575
    Abstract: An attachment of a stockless anchor on the sea floor encourages flukes to tilt as soon as the vessel pulls away, while maintaining stability on the floor. The weight of the flukes act as a pivot with the crown of the stockless anchor that, when placed on the floor, causes the anchor to become attached by being buried in the floor when the vessel pulls away. The attachment comprises two claws fastened to the flanks of the flukes at or in close proximity of the crown on the pivot axis of the flukes, thereby enabling them to tilt and become attached immediately in the floor as soon as the anchor is placed on the floor. When the vessel pulls away the anchor is open and becomes attached immediately. An attachment to the floor avoids or reduces dragging of the anchor on the floor.
    Type: Grant
    Filed: September 7, 2016
    Date of Patent: September 8, 2020
    Inventor: Alain Nicolas Maurin
  • Patent number: 10348284
    Abstract: A summing circuit, including a capacitor, a switching circuit capable of connecting the capacitor between a first node (ana) and a second node (ref), between a third node and the second node in a first connection direction or between the third node and the second node in a second connection direction, an integrator coupled to the third node, a hysteresis comparator coupled to the output of the integrator, and a counter coupled to the output of the hysteresis comparator.
    Type: Grant
    Filed: September 25, 2017
    Date of Patent: July 9, 2019
    Assignee: Commissariat à l'Énergie Atomique et aux Énergies Alternatives
    Inventors: Jean-Pierre Rostaing, Bertrand Dupont, Nicolas Monnier, Jean-Alain Nicolas
  • Publication number: 20190039693
    Abstract: An attachment of a stockless anchor on the sea floor encourages flukes to tilt as soon as the vessel pulls away, while maintaining stability on the floor. The weight of the flukes act as a pivot with the crown of the stockless anchor that, when placed on the floor, causes the anchor to become attached by being buried in the floor when the vessel pulls away. The attachment comprises two claws fastened to the flanks of the flukes at or in close proximity of the crown on the pivot axis of the flukes, thereby enabling them to tilt and become attached immediately in the floor as soon as the anchor is placed on the floor. When the vessel pulls away the anchor is open and becomes attached immediately. An attachment to the floor avoids or reduces dragging of the anchor on the floor.
    Type: Application
    Filed: September 7, 2016
    Publication date: February 7, 2019
    Inventor: Alain Nicolas MAURIN
  • Publication number: 20180091129
    Abstract: A summing circuit, including a capacitor, a switching circuit capable of connecting the capacitor between a first node (ana) and a second node (ref), between a third node and the second node in a first connection direction or between the third node and the second node in a second connection direction, an integrator coupled to the third node, a hysteresis comparator coupled to the output of the integrator, and a counter coupled to the output of the hysteresis comparator.
    Type: Application
    Filed: September 25, 2017
    Publication date: March 29, 2018
    Applicant: Commissariat à l'Énergie Atomique et aux Énergies Alternatives
    Inventors: Jean-Pierre Rostaing, Bertrand Dupont, Nicolas Monnier, Jean-Alain Nicolas
  • Publication number: 20180023091
    Abstract: The present invention relates to a fusion protein comprising a Cas9 domain and a Spo11 domain, as well as the use of this protein to induce targeted meiotic recombinations in a eukaryotic cell.
    Type: Application
    Filed: January 29, 2016
    Publication date: January 25, 2018
    Applicants: MEIOGENIX, INSTITUT CURIE, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITE PIERRE ET MARIE CURIE (PARIS 6)
    Inventors: GIACOMO BASTIANELLI, ALEXANDRE SERERO, ALAIN NICOLAS
  • Publication number: 20150307868
    Abstract: The present invention relates to a method for improving an industrial yeast strain of industrial interest, particularly a sterile hybrid strain, without resorting to recombinant DNA techniques
    Type: Application
    Filed: November 29, 2013
    Publication date: October 29, 2015
    Inventors: ALAIN NICOLAS, GIANNI LITI
  • Patent number: 8232836
    Abstract: The invention relates to an integrated circuit comprising a succession of N identical elementary circuits (CE1, CE2, . . . CEN), juxtaposed in the order of their rank j varying from 1 to N, N being at least equal to 50, and all having to receive two reference potentials Vref and V0 supplied by two conductors. An upstream input of the second conductor is situated geographically on the side of the rank 1 of the succession of juxtaposed circuits, and an upstream input of the first conductor is situated geographically on the side of the rank N of the succession of juxtaposed circuits. This reduces the error in the potential difference applied to the elementary circuits all along the succession, an error that originates from the non-zero resistance of the conductors. The integrated circuit is applicable to analog-digital converters or digital-analog converters with high resolution.
    Type: Grant
    Filed: January 28, 2009
    Date of Patent: July 31, 2012
    Assignee: E2V Semiconductors
    Inventors: Jean-Alain Nicolas, Richard Morisson
  • Patent number: 7999713
    Abstract: The invention relates to fast, high resolution, analog digital converters, and more particularly those which possess at least one conversion stage of “flash” type. The converter according to the invention uses N differential amplifiers with four inputs. The amplifier of rank j receives the input voltage to be converted Vep?Ven on two first inputs, and a reference potential difference on two other inputs. The reference potential difference is obtained between two taps of networks of resistors that are identical operating in parallel and supplied between a high voltage source and a low current source; the taps for an amplifier are respectively a tap Pj of rank j of a first network and a tap P?N?j+1 of rank N?j+1 of a second network. This reduces the first and second order non-linearity effects due to the fact that the differential amplifiers consume an input current tapped off from the networks of resistors.
    Type: Grant
    Filed: March 13, 2008
    Date of Patent: August 16, 2011
    Assignee: E2V Semiconductors
    Inventors: Jean-Alain Nicolas, Richard Morisson