Patents by Inventor Alain Pierre

Alain Pierre has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 5807882
    Abstract: A compound of formula (I): ##STR1## in which R.sup.1, R.sup.2, X and Y are as defined in the description, the isomers thereof and the addition salts thereof with a pharmaceutically acceptable acid or base, and medicinal products containing the same are useful in the treatment of certain cancers.
    Type: Grant
    Filed: November 7, 1997
    Date of Patent: September 15, 1998
    Assignee: Adir et Compagnie
    Inventors: Gerard Coudert, Siham Khatib, Pascale Moreau, Daniel-Henri Caignard, Pierre Renard, Ghanem Atassi, Alain Pierre
  • Patent number: 5648382
    Abstract: Compounds of formula (I): ##STR1## wherein: R is selected from the radicals: ##STR2## Y is selected from ##STR3## R.sub.1 represents the radical ##STR4## and A, B, C, D, R.sub.2, R.sub.3 and R.sub.4 are as defined in the description, and also the possible geometric isomers and/or diastereoisomers and/or enantiomers thereof in pure form or in the form of a mixture. The compounds of the present invention have a therapeutic use as a result of their angiogenesis-inhibiting activity.
    Type: Grant
    Filed: April 29, 1996
    Date of Patent: July 15, 1997
    Assignee: Adir et Compagnie
    Inventors: David Billington, Isabelle Picard, Ghanem Atassi, Alain Pierre, Michael Burbridge, Nicolas Guilbaud
  • Patent number: 5595976
    Abstract: A compound selected from those of formula (I): ##STR1## in which: A either represents --OR.sub.6, and B represents --CH.sub.2 --X,or, together with B and the carbon atom carrying them, forms an oxygen-containing heterocycle selected from oxirane, 2,2-dimethyl[1,3]dioxolane and [1,3]dioxolan-2-one,and R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, R.sub.6 and X are as defined in the description.
    Type: Grant
    Filed: August 30, 1995
    Date of Patent: January 21, 1997
    Assignee: Adir et Compagnie
    Inventors: David Billington, Gilbert Dorey, Pascale Leon, Ghanem Atassi, Alain Pierre, Michael Burbridge, Nicolas Guilbaud
  • Patent number: 5567707
    Abstract: Compounds of formula (I): ##STR1## wherein R.sub.3, R.sub.4, R.sub.5, R.sub.6, X and Y are defined in the description.Those compounds are used therapeutically in the treatment of cancerous tumours.
    Type: Grant
    Filed: February 16, 1995
    Date of Patent: October 22, 1996
    Assignee: Adir et Compagnie
    Inventors: Michel Koch, Fran.cedilla.ois Tillequin, Alexios-Leandros Skaltsounis, Yves Rolland, Alain Pierre, Ghanem Atassi
  • Patent number: 5508277
    Abstract: Novel bicyclic pyrimidine compounds for use as drugs and having formula (I). Said novel compounds and physiologically tolerable salts thereof may be used in therapeutics, particularly for suppressing tumour cell resistance to antineoplastic agents.
    Type: Grant
    Filed: August 10, 1994
    Date of Patent: April 16, 1996
    Assignee: Adir Et Compagnie
    Inventors: Gilbert Regnier, Alain Dhainaut, Ghanem Atassi, Alain Pierre
  • Patent number: 5409952
    Abstract: A compound of the formula (I) ##STR1## in which: R.sub.1 represents a hydrogen atom, a lower alkyl group, a hydroxy group or a lower alkoxy group,R.sub.2, R.sub.3, R.sub.4, R.sub.5, R.sub.6, R.sub.7, R.sub.8 and R.sub.11 are as defined in the description.Medicaments.
    Type: Grant
    Filed: October 27, 1993
    Date of Patent: April 25, 1995
    Assignee: Adir et Compagnie
    Inventors: Jean D. Brion, Guillaume Le Baut, Francoise Zammatio, Alain Pierre, Ghanem Atassi, Larbi Belachmi
  • Patent number: 5405948
    Abstract: A compound of formula (I): selected from 1,5-diyne-3-cyclodecene and undecene compounds. ##STR1## in which: R represents a hydrogen atom, a straight-chain or branched (C.sub.1 -C.sub.6) acyl radical or a glycoside radical,R' represents a hydrogen atom ##STR2## n is 1 or 2, and R.sub.1 and R.sub.2 simultaneously represent two hydrogen atoms or, together with the two carbon atoms and the double bond to which they are attached, form a phenyl ring.
    Type: Grant
    Filed: September 30, 1992
    Date of Patent: April 11, 1995
    Assignee: Adir et Compagnie
    Inventors: Jean-Marie Beau, Christophe Crevisy, Ghanem Atassi, Alain Pierre
  • Patent number: 5389644
    Abstract: The compounds are 2,4-disubstituted 3-ethoxycarbonyl 5-methoxycarbonyl 6-methyl 1,4-dihydropyridines in their dextrorotatory form, useful to potentiate the activity of cytotoxic agents and to increase the sensitivity of tumor cells to antitumor agents.A compound disclosed is d-2-{[2-(2-(N-p-nitrobenzylamino)ethoxy)ethoxy]methyl}-4-(2,3-dichlorophen yl)-3-ethoxycarbonyl-5-methoxycarbonyl-6-methyl-1,4-dihydropyridine.
    Type: Grant
    Filed: February 4, 1993
    Date of Patent: February 14, 1995
    Assignee: Adir et Compagnie
    Inventors: Jean-Louis Peglion, Ghanem Aasssi, Alain Pierre, Laurence Kraus-Berthier, Nicolas Guilbaud, Jean-Paul Vilaine
  • Patent number: 5238936
    Abstract: The compounds are trisubstituted triazines and pyrimidines useful for the suppressing the resistance of tumour cells to anti-cancer agents and for suppressing the resistance of parasites to anti-parasitic agents.A compound disclosed is 2,4-diallylamino-6-{4-[(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-yl) methylamino]piperidin-1-yl}-1,3,5-triazine.
    Type: Grant
    Filed: March 6, 1992
    Date of Patent: August 24, 1993
    Assignee: Adir et Compagnie
    Inventors: Gilbert Regnier, Alain Dhainaut, Ghanem Atassi, Alain Pierre, Stephane Leonce
  • Patent number: 5225411
    Abstract: The compounds are 2,4-(optionally substituted amino)-6-substituted s.triazines, useful for suppressing the resistance of tumour cells to anti-cancer agents and for suppressing the resistance of parasites to anti-parasitic agents.A compound disclosed is 1-[4,6-bis(allylamino)-2-s-triazinyl]-4-[2,2-bis(p.fluorophenyl)ethylamino ]piperidine.
    Type: Grant
    Filed: July 10, 1991
    Date of Patent: July 6, 1993
    Assignee: Adir et Compagnie
    Inventors: Gilbert Regnier, Alain Dhainaut, Ghanem Atassi, Alain Pierre, Stephane Leonce
  • Patent number: 5100881
    Abstract: The invention relates to the compounds of general formula I: ##STR1## in which: R.sub.1 represents a hydrogen atom, a linear or branched alkyl radical containing from 1 to 6 carbon atoms, a linear or branched alkenyl radical containing from 2 to 6 carbon atoms, an arylalkyl radical having 7 to 10 carbon atoms and which can bear a halogen atom as a substituent on the aromatic ring, a hydroxyl radical or an alkyl or alkoxy radical each containing from 1 to 5 carbon atoms, a 2-indolylmethyl radical, a 4-imidazolylmethyl radical or an alkoxycarbonylmethyl radical containing from 3 to 11 carbon atoms,R.sub.2 and R.sub.3, which may be identical or different, each represents a linear or branched alkyl radical containing from 1 to 6 carbon atoms,n is equal to 1 or 2,R.sub.4 represents a hydrogen atom, a formyl radical or a methyl radical, with the proviso, however, that R.sub.4 is never the methyl radical when n is equal to 2, andeither R.sub.5 and R.sub.6 together form a double bond, or R.sub.
    Type: Grant
    Filed: August 1, 1990
    Date of Patent: March 31, 1992
    Assignee: Adir et Compagnie
    Inventors: Gilbert Lavielle, Patrick Hautefaye, Alain Pierre
  • Patent number: 5084440
    Abstract: Novel odorants, namely acetals and ketals of alkyl-substituted oxo-tetralins and oxo-indanes, are described.
    Type: Grant
    Filed: January 24, 1990
    Date of Patent: January 28, 1992
    Assignee: Givaudan Corporation
    Inventors: Josianne Baudin, Alain-Pierre Bonenfant, Hans U. Gonzenbach
  • Patent number: 4785168
    Abstract: A device for detecting and localizing neutral particles such as X photons, gamma photons or neutrons is essentially constituted by a solid converter (2) disposed at a glancing incidence relative to the radication to be detected, together with networks of wires such as (3') disposed in the proximity of the converter. The device is applicable to industrial imaging.
    Type: Grant
    Filed: November 25, 1986
    Date of Patent: November 15, 1988
    Assignee: Enertec
    Inventors: Mario Ruscev, Irene Dorion, Alain-Pierre Lilot
  • Patent number: 4626088
    Abstract: A device for measuring a subject's ocular parameters, in particular the interpupillary distance, comprises a front plate against which the face of the subject is placed, comprising two windows substantially corresponding to the lenses of a pair of eyeglasses. A lens is movable along its optical axis, which is perpendicular to the front plate, from an origin position near the front plate. A viewing eyepiece is disposed at the focus of the lens when in the origin position. A semi-reflecting mirror disposed at 45.degree. renders the eyepiece and a point source coincident, as far as the subject is concerned. Parallel to the semi-reflecting mirror, another mirror reflects an image of a cathode ray tube screen to the eyepiece through another lens. Adjustable calibrated voltage sources are used to produce coincidence of the reflections of the source on the corneas of the eyes of the subject and the luminous traces on the screen of the cathode ray tube, as seen by an operator looking through the eyepiece.
    Type: Grant
    Filed: December 19, 1984
    Date of Patent: December 2, 1986
    Assignee: Essilor International Cie Generale d'Optique
    Inventors: Christian Joncour, Alain Pierre, Patrice Renan, Jean-Louis Roumegoux, Francoise Richard, deceased, by Jacques M. G. Richard, heir, Alexandra A. C. Richard, heir, Anne-Lise P. M. Richard, heir
  • Patent number: 4612736
    Abstract: The peripheral edge of an ophthalmic lens is maintained in contact with a bevelling or grooving wheel while being rotated about an axis of the lens parallel to the axis of the bevelling wheel whereby a bevel or groove is formed in said peripheral edge. The ophthalmic lens is capable of relative axial displacement relative to said bevelling wheel. By way of a force or displacement sensor, the relative axial position of the ophthalmic lens with respect to the bevelling wheel can be made subject to the axial component of reaction forces generated between the lens and the bevelling wheel in their mutual contact zone.
    Type: Grant
    Filed: October 16, 1984
    Date of Patent: September 23, 1986
    Assignee: Essilor International Cie Generale d'Optique
    Inventors: Christian Massard, Alain Pierre, Jean-Louis Roumegoux
  • Patent number: 4470824
    Abstract: The pulley of moulded plastics material is mounted adjacent to the outer side of the bicycle wheel flange, concentrically with this flange. The pulley comprises a grooved ring around which extends a belt for driving a distance recorder. From the periphery of the ring, on the side of the latter adjacent to the wheel flange, extend in generally radial directions are three arms which are angularly spaced 120.degree. apart. Mounted on the free end portion of the arms by means of a pivot pin are the end portions of tabs which are provided with a mounting device at the opposite end. This mounting device is adapted to engage with a wheel spoke so as to maintain the pulley in a centered position relative to the wheel flange.
    Type: Grant
    Filed: March 8, 1982
    Date of Patent: September 11, 1984
    Assignee: Huret et ses Fils
    Inventors: Roger Huret, deceased, by Alain Pierre Bernard Huret, legal representative