Abstract: Methods and apparatuses are described for predictive analysis of transaction data using machine learning. A server computing device trains a plurality of machine learning models using historical transaction data for a set of entities as input to predict a likelihood of future transaction activity for each of the entities, each machine learning model trained on a different target transaction variable. The server computing device executes each of the plurality of machine learning models to generate, for each entity, a predicted likelihood value for a future transaction associated with the entity and each of the target transaction variables. The server computing device transmits the predicted likelihood values for each entity to a remote computing device for display.

Abstract: An electronic payment device intended to be integrated into an unattended electronic payment terminal. The electronic payment device includes at least one electronic card, a screen, a keyboard and a contactless payment module. The contactless payment module has at least one contactless antenna arranged on a plane, called antenna plane, raised by a first predetermined distance with respect to the plane of the keyboard and raised by a second predetermined distance with respect to the plane of the screen. The second predetermined distance is smaller than the first predetermined distance.

Abstract: The present invention relates to an antibody-drug-conjugate capable of binding IGF-1R. From one aspect, the invention relates to an antibody-drug-conjugate comprising an antibody capable of binding to IGF-1R, said antibody being conjugated to at least one drug selected from derivatives of dolastatin 10 and auristatins. The invention also comprises method of treatment and the use of said antibody-drug-conjugate for the treatment of cancer.

Abstract: The present invention relates to an antibody, in particular a monoclonal antibody, capable of binding to IGF-1R, as well as the amino and nucleic acid sequences coding for said antibody. From one aspect, the invention relates to an antibody, or an antigen binding fragment thereof, capable of binding to IGF-1R and, by inducing internalization of IGF-1R, being internalized into the cell. The invention also comprises the use of said antibody as an addressing product or vehicle in conjugation with other anti-cancer compounds such as toxins, radio-elements or drugs, and the use of same for the treatment of certain cancers.

Abstract: The present invention relates to a method for the treatment of IGF-IR expressing cancers as well as to a compositions and a kit for said traitment. From one aspect, the invention relates to the combined use of a first antibody for the determination of the IGF-IR status of a cancer and a second antibody used as an ADC for the treatment of said cancer.

Abstract: The present invention relates to an antibody-drug-conjugate capable of binding IGF-1R. From one aspect, the invention relates to an antibody-drug-conjugate comprising an antibody capable of binding to IGF-1R, said antibody being conjugated to at least one drug selected from derivatives of dolastatin 10 and auristatins. The invention also comprises method of treatment and the use of said antibody-drug-conjugate for the treatment of cancer.

Abstract: The invention relates to a system and method for improving the quality of hand hygiene. It comprises a portable bottle of disinfectant equipped with electronics and an electronic wristband. It gives different real-time feedback to its user regarding the quantity of disinfectant used, the duration of hand rubbing and the compliance of his/her rubbing gestures with a reference sequence. According to variations, the bottle can be used on its own.

Abstract: The present invention relates to an antibody-drug-conjugate capable of binding IGF-1R. From one aspect, the invention relates to an antibody-drug-conjugate comprising an antibody capable of binding to IGF-1R, said antibody being conjugated to at least one drug selected from derivatives of dolastatin 10 and auristatins. The invention also comprises method of treatment and the use of said antibody-drug-conjugate for the treatment of cancer.

Abstract: The present invention relates to an antibody, in particular a monoclonal antibody, capable of binding to IGF-1R, as well as the amino and nucleic acid sequences coding for said antibody. From one aspect, the invention relates to an antibody, or an antigen binding fragment thereof, capable of binding to IGF-1R and, by inducing internalization of IGF-1R, being internalized into the cell. The invention also comprises the use of said antibody as an addressing product or vehicle in conjugation with other anti-cancer compounds such as toxins, radio-elements or drugs, and the use of same for the treatment of certain cancers.

Abstract: The present invention relates to an antibody, in particular a monoclonal antibody, capable of binding to IGF-1R, as well as the amino and nucleic acid sequences coding for said antibody. From one aspect, the invention relates to an antibody, or an antigen binding fragment thereof, capable of binding to IGF-1R and, by inducing internalization of IGF-1R, being internalized into the cell. The invention also comprises the use of said antibody as an addressing product or vehicle in conjugation with other anti-cancer compounds such as toxins, radio-elements or drugs, and the use of same for the treatment of certain cancers.

Abstract: A process for making a device comprising a thin functional substrate comprising bonding the functional substrate to a carrier substrate, forming functional components on the functional subsrate, and debonding the functional substrate from the carrier substrate by applying ultrasonic wave to the bonding interface. The application of ultrasonic wave aids the debonding step by reducing the tensile stress the functional substrate may experience.

Abstract: The present invention relates to an antibody, in particular a monoclonal antibody, capable of binding to IGF-1R, as well as the amino and nucleic acid sequences coding for said antibody. From one aspect, the invention relates to an antibody, or an antigen binding fragment thereof, capable of binding to IGF-1R and, by inducing internalization of IGF-1R, being internalized into the cell. The invention also comprises the use of said antibody as an addressing product or vehicle in conjugation with other anti-cancer compounds such as toxins, radio-elements or drugs, and the use of same for the treatment of certain cancers.

Abstract: A method for the production of a fibrous metal structure by weaving with metal weft yarns and metal warp yarns. The method includes weaving the fibrous structure by successive weaving of metal clasps that are used as weft yarns. For the purpose of weaving, each of the arms of each of the metal clasps is introduced into at least one shed, each shed being formed by two warp yarns.

Abstract: The present invention relates to an antibody-drug-conjugate capable of binding IGF-1R. From one aspect, the invention relates to an antibody-drug-conjugate comprising an antibody capable of binding to IGF-1R, said antibody being conjugated to at least one drug selected from derivatives of dolastatin 10 and auristatins. The invention also comprises method of treatment and the use of said antibody-drug-conjugate for the treatment of cancer.

Abstract: A method for producing a metal component such as a metal turbomachine blade reinforcement, includes positioning a plurality of metal staples in a forming tool having a die and a punch; and hot isostatic pressing the plurality of metal staples causing the agglomeration of the metal staples so as to obtain a solid component.

Abstract: A process for manufacturing a metal part such as a metal reinforcement for the blade of a turbine engine, which includes: manufacturing a three-dimensional metal structure made up of an insert which exhibits properties which allow superplastic forming and diffusion welding to be carried out, and of multiple metal wires encircling the periphery of the insert, where the metal structure forms a preform of the metal part; positioning the metal structure in a forming tool and hot-pressing the three-dimensional metal structure which causes agglomeration of the metal structure so as to obtain the compact metal part.

Abstract: A method for producing a metal reinforcement for the leading edge or trailing edge of a turbomachine blade, the method including cutting a plurality of metal foils from a flexible metal sheet, corresponding substantially to the developed length of the leading or trailing edge metal reinforcement; producing a plurality of metal pockets, each pocket being produced from two of the metal foils obtained during the cutting; stacking the metal pockets one inside the other, such as to form a preform of the leading or trailing edge metal reinforcement; and hot isostatic pressing the preform, causing the metal pockets to bond to one another, so as to produce the leading or trailing edge metal reinforcement.

Abstract: A method for producing a solid part, including weaving a three-dimensional fibrous structure, the weaving being carried out with metal braids consisting of a plurality of metal strands mutually twisted about the longitudinal axis of the braid; and performing hot isostatic pressing on the fibrous structure causing the agglomeration of the metal braids of the fibrous structure so as to produce a solid part.

Abstract: A method for making a metallic part, includes positioning at least one metallic coil formed from flexible metal foil including a plurality of notches, on a shaping tool, the at least one coil being manually deformable when cold along three directions in space (X, Y, Z); hot isostatic pressing the at least one metallic coil in a tool causing compaction of the metallic coil so as to obtain the metallic part.

Abstract: A method for manufacturing a metal part by producing a preform with a fibrous structure of metal fibers, and subjecting the preform to hot isostatic pressing in a tool until a solid part is obtained, the tool including at least one first element including a cavity for molding the part. The first tool element is elongate in a direction between two ends, and the fibrous structure is at least partially formed by winding at least one metal wire around the first tool element in the direction, from one end to the other. The method can be used, for example, for manufacturing reinforcement parts for a fan blade of a turbojet engine.