Patents by Inventor Alam Jahangir

Alam Jahangir has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Diaminopyrimidines as P2X3 and P2X2/3 modulators
    Publication number: 20070049758
    Abstract: Compounds and methods for treating diseases mediated by a P2X3 and/or a P2X2/3 receptor antagonist, the methods comprising administering to a subject in need thereof an effective amount of a compound of formula (I): wherein D, X, R1, R2, R3, R4, R5, R6, R7 and R8 are as defined herein.
    Type: Application
    Filed: August 25, 2006
    Publication date: March 1, 2007
    Inventors: Michael Dillon, Alam Jahangir, Amy Moore, Paul Wagner
  • Methods of using diaminopyrimidine P2X3 and P2X2/3 receptor modulators for treatment of respiratory and gastrointestinal diseases
    Publication number: 20070049609
    Abstract: Methods for treating respiratory and gastrointestinal diseases mediated by a P2X3 and/or a P2X2/3 receptor antagonist, the methods comprising administering to a subject in need thereof an effective amount of a compound of formula (I): or a pharmaceutically acceptable salt thereof, wherein D, X, Y, R1, R2, R3, R4, R5, R6, R7 and R8 are as defined herein.
    Type: Application
    Filed: August 25, 2006
    Publication date: March 1, 2007
    Inventors: Chris Broka, David Carter, Michael Dillon, Anthony Ford, Ronald Hawley, Alam Jahangir, Amy Moore, Daniel Parish
  • Diaminopyrimidines as P2X3 and P2X2/3 modulators
    Publication number: 20070049610
    Abstract: Compounds of the formula I: or pharmaceutically acceptable salts thereof, wherein A, D, E, G, J, X, Y, Z R6, R7 and R8 are as defined herein. Also provided are methods of using the compounds for treating diseases mediated by a P2X3 and/or a P2X2/3 receptor antagonist and methods of making the compounds.
    Type: Application
    Filed: August 25, 2006
    Publication date: March 1, 2007
    Inventors: Michael Dillon, Alam Jahangir, Alfred Lui, Robert Wilhelm
  • 2-(substituted-phenyl)amino-imidazoline derivatives
    Patent number: 7141584
    Abstract: This invention relates to IP receptor antagonists selected from the group of compounds represented by Formula I: where: R1 is a group represented by formula (A), (B) or (C); and other substituents as defined in the specification, and their pharmaceutically acceptable salts or crystal forms thereof; and pharmaceutical compositions containing them; and methods for their use as therapeutic agents.
    Type: Grant
    Filed: December 9, 2003
    Date of Patent: November 28, 2006
    Assignee: Roche Palo Alto LLC
    Inventors: Keith Roger Bley, Robin Douglas Clark, Alam Jahangir, Bruce Andrew Kowalczyk, Francisco Javier Lopez-Tapia, Alexander Victor Muehldorf, Counde O'Yang, Thomas Weitao Sun
  • Thiophenylaminoimidazolines as IP antagonists
    Patent number: 7078401
    Abstract: Methods for treatment of IP antagonist mediated diseases or conditions by administration to a subject in need thereof a compound of formula (I) wherein R1, R2, A and X are as defined herein. Also disclosed are compounds and related compositions.
    Type: Grant
    Filed: July 9, 2004
    Date of Patent: July 18, 2006
    Assignee: Roche Palo Alto LLC
    Inventors: Keith Roger Bley, Robin Douglas Clark, Alam Jahangir
  • Substituted arylamides as IP antagonists
    Patent number: 6998414
    Abstract: Compounds effective as IP receptor modulators, particularly IP receptor antagonists, that are of the formula I: wherein A, R1, R2, R3 and R4 are as defined in the specification; and individual isomers, racemic or non-racemic mixtures of isomers, and pharmaceutically acceptable salts or solvates thereof. Also disclosed are pharmaceutical compositions containing such compounds and methods for their use as therapeutic agents.
    Type: Grant
    Filed: April 29, 2004
    Date of Patent: February 14, 2006
    Assignee: Roche Palo Alto LLC
    Inventors: Paul Francis Keitz, Alam Jahangir, Francisco Javier Lopez-Tapia, Counde O'Yang
  • Substituted aryl amides as IP antagonists
    Publication number: 20060004075
    Abstract: Compounds effective as IP receptor modulators, particularly IP receptor antagonists, that are of the formula I: wherein A, R1, R2, R3 and R4 are as defined in the specification; and individual isomers, racemic or non-racemic mixtures of isomers, and pharmaceutically acceptable salts or solvates thereof. Also disclosed are pharmaceutical compositions containing such compounds and methods for their use as therapeutic agents.
    Type: Application
    Filed: September 1, 2005
    Publication date: January 5, 2006
    Inventors: Paul Keitz, Alam Jahangir, Francisco Lopez-Tapia, Counde O'Yang
  • Diaminopyrimidines as P2X3 and P2X2/3 antagonists
    Publication number: 20050209260
    Abstract: Compounds and methods for treating diseases mediated by a P2X3 and/or a P2X2/3 receptor antagonist, the methods comprising administering to a subject in need thereof an effective amount of a compound of formula (I): or a pharmaceutically acceptable salt, solvate or prodrug thereof, wherein D, X, Y, R1, R2, R3, R4, R5, R6, R7 and R8 are as defined herein.
    Type: Application
    Filed: March 3, 2005
    Publication date: September 22, 2005
    Inventors: Chris Broka, David Carter, Michael Dillon, Ronald Hawley, Alam Jahangir, Clara Lin, Daniel Parish
  • Spiro tetrahydroquinazolines and dihydrocyclopentapyrimidines as CRF antagonists
    Publication number: 20050113382
    Abstract: Compounds of the formula (I): and pharmaceutically acceptable salts or prodrugs thereof, wherein X, Y, Z and R1 are as defined herein. The invention also provides methods for preparing, compositions comprising, and methods for using compounds of formula I.
    Type: Application
    Filed: November 24, 2004
    Publication date: May 26, 2005
    Inventors: Alam Jahangir, Counde O'Yang
  • Thiophenylaminoimidazolines as IP antagonists
    Publication number: 20050020648
    Abstract: Methods for treatment of IP antagonist mediated diseases or conditions by administration to a subject in need thereof a compound of formula (I) wherein R1, R2, A and X are as defined herein. Also disclosed are compounds and related compositions.
    Type: Application
    Filed: July 9, 2004
    Publication date: January 27, 2005
    Inventors: Keith Bley, Robin Clark, Alam Jahangir
  • Substituted arylamides as IP antagonists
    Publication number: 20040220247
    Abstract: Compounds effective as IP receptor modulators, particularly IP receptor antagonists, that are of the formula I: 1
    Type: Application
    Filed: April 29, 2004
    Publication date: November 4, 2004
    Applicant: Roche Palo Alto LLC
    Inventors: Paul Francis Keitz, Alam Jahangir, Francisco Javier Lopez-Tapia, Counde O'Yang
  • 2-(substituted-phenyl)amino-imidazoline derivatives
    Publication number: 20040122053
    Abstract: This invention relates to IP receptor antagonists selected from the group of compounds represented by Formula I: 1
    Type: Application
    Filed: December 9, 2003
    Publication date: June 24, 2004
    Inventors: Keith Roger Bley, Robin Douglas Clark, Alam Jahangir, Bruce Andrew Kowalczyk, Francisco Javier Lopez-Tapia, Alexander Victor Muehldorf, Counde O'Yang, Thomas Weitao Sun
  • 2-(substituted-phenyl)amino-imidazoline derivatives
    Patent number: 6693200
    Abstract: This invention relates to IP receptor antagonists selected from the group of compounds represented by Formula I: where: R1 is a group represented by formula (A), (B) or (C); and other substituents as defined in the specification, and their pharmaceutically acceptable salts or crystal forms thereof; and pharmaceutical compositions containing them; and methods for their use as therapeutic agents.
    Type: Grant
    Filed: April 29, 2003
    Date of Patent: February 17, 2004
    Assignee: Syntex (U.S.A.) LLC
    Inventors: Keith Roger Bley, Robin Douglas Clark, Alam Jahangir, Bruce Andrew Kowalczyk, Francisco Javier Lopez-Tapia, Alexander Victor Muehldorf, Counde O'Yang, Thomas Weitao Sun
  • 2-(Substituted-phenyl)amino-imidazoline derivatives
    Publication number: 20030229123
    Abstract: This invention relates to IP receptor antagonists selected from the group of compounds represented by Formula I: 1
    Type: Application
    Filed: April 29, 2003
    Publication date: December 11, 2003
    Inventors: Keith Roger Bley, Robin Douglas Clark, Alam Jahangir, Bruce Andrew Kowalczyk, Francisco Javier Lopez-Tapia, Alexander Victor Muehldorf, Counde O'Yang, Thomas Weitao Sun
  • 2-(substituted-phenyl)amino-imidazoline derivatives
    Patent number: 6596876
    Abstract: This invention relates to IP receptor antagonists selected from the group of compounds represented by Formula I: where: R1 is a group represented by formula (A), (B) or (C);  and other substituents as defined in the specification, and their pharmaceutically acceptable salts or crystal forms thereof; and pharmaceutical compositions containing them; and methods and their use as therapeutic agents.
    Type: Grant
    Filed: May 31, 2002
    Date of Patent: July 22, 2003
    Assignee: Syntex (U.S.A.) LLC
    Inventors: Keith Roger Bley, Robin Douglas Clark, Alam Jahangir, Bruce Andrew Kowalczyk, Francisco Javier Lopez-Tapia, Alexander Victor Muehldorf, Counde O'Yang, Thomas Weitao Sun
  • 2-(substituted-phenyl)amino-imidazoline derivatives
    Publication number: 20030036655
    Abstract: This invention relates to IP receptor antagonists selected from the group of compounds represented by Formula I: 1
    Type: Application
    Filed: May 31, 2002
    Publication date: February 20, 2003
    Inventors: Keith Roger Bley, Robin Douglas Clark, Alam Jahangir, Bruce Andrew Kowalczyk, Francisco Javier Lopez-Tapia, Alexander Victor Muehldorf, Counde O'Yang, Thomas Weitao Sun
  • 2-(substituted-phenyl)amino-imidazoline derivatives
    Patent number: 6472536
    Abstract: This invention relates to IP receptor antagonists selected from the group of compounds represented by Formula I: where: R1 is a group represented by formula (A), (B) or (C); and other substituents as defined in the specification, and their pharmaceutically acceptable salts or crystal forms thereof; and pharmaceutical compositions containing them; and methods for their use as therapeutic agents.
    Type: Grant
    Filed: September 19, 2000
    Date of Patent: October 29, 2002
    Assignee: Syntex (U.S.A.) LLC
    Inventors: Keith Roger Bley, Robin Douglas Clark, Alam Jahangir, Bruce Andrew Kowalczyk, Francisco Javier Lopez-Tapia, Alexander Victor Muehldorf, Counde O'Yang, Thomas Weitao Sun
  • SUBSTITUTED-PHENYL KETONE DERIVATIVES AS IP ANTAGONISTS
    Publication number: 20020091147
    Abstract: This invention relates to compounds which are generally IP receptor modulators, particularly IP receptor antagonists, and which are represented by Formula I: 1
    Type: Application
    Filed: November 13, 2001
    Publication date: July 11, 2002
    Inventor: Alam Jahangir
  • Substituted-phenyl ketone derivatives as IP antagonists
    Patent number: 6417186
    Abstract: This invention relates to compounds which are generally IP receptor modulators, particularly IP receptor antagonists, and which are represented by Formula I: wherein A, R1 and R2 are as defined in the specification; and individual isomers, racemic or non-racemic mixtures of isomers, and pharmaceutically acceptable salts or solvates thereof. The invention further relates to pharmaceutical compositions containing such compounds and methods for their use as therapeutic agents.
    Type: Grant
    Filed: November 13, 2001
    Date of Patent: July 9, 2002
    Assignee: Syntex (U.S.A.) LLC
    Inventor: Alam Jahangir
  • 2-(substituted-phenyl)amino-imidazoline derivatives
    Patent number: 6184242
    Abstract: This invention relates to IP receptor antagonists selected from the group of compounds represented by Formula I: where: R1 is a group represented by formula (A), (B) or (C); and other substituents as defined in the specification, and their pharmaceutically acceptable salts or crystal forms thereof; and pharmaceutical compositions containing them; and methods for their use as therapeutic agents.
    Type: Grant
    Filed: August 20, 1998
    Date of Patent: February 6, 2001
    Assignee: Syntex USA (LLC)
    Inventors: Keith Roger Bley, Robin Douglas Clark, Alam Jahangir, Bruce Andrew Kowalczyk, Francisco Javier Lopez-Tapia, Alexander Victor Muehldorf, Counde O'Yang, Thomas Weitao Sun