Patents by Inventor Alan A. DiSpirito

Alan A. DiSpirito has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 8629239
    Abstract: The present disclosures provides isolated or purified compounds, each of which bind to a metal atom. Generally, the compounds are small in size (e.g, molecular weight of less than about 1 kDa) and peptidic in nature, inasmuch as the compounds comprise amino acids. In some embodiments, the compound comprises a structure of Formula I: M1-P1-M2-P2 wherein each of P1 and P2 is a peptide comprising at least two amino acids, M1 is a first metal binding moiety comprising a substituted imidazolone ring, M2 is a second metal binding moiety comprising a substituted oxazolone ring, and wherein M1 and M2 bind to a single metal atom. Also provided are related complexes, conjugates, cells which synthesize the compounds of the present disclosures, substantially homogenous cultures thereof, kits and compositions, and methods of making or using the materials of the present disclosures.
    Type: Grant
    Filed: August 4, 2011
    Date of Patent: January 14, 2014
    Assignees: Iowa State University Research Foundation, Inc., The Regents of the University of Michigan, WiSys Technology Foundation
    Inventors: Jeremy D. Semrau, Warren Gallagher, Sukhwan Yoon, Jeongdae Im, Alan A. DiSpirito, Sung-Woo Lee, Scott Hartsel, Marcus T. McEllistrem
  • Publication number: 20120034594
    Abstract: The present disclosures provides isolated or purified compounds, each of which bind to a metal atom. Generally, the compounds are small in size (e.g, molecular weight of less than about 1 kDa) and peptidic in nature, inasmuch as the compounds comprise amino acids. In some embodiments, the compound comprises a structure of Formula I: M1-P1-M2-P2 wherein each of P1 and P2 is a peptide comprising at least two amino acids, M1 is a first metal binding moiety comprising a substituted imidazolone ring, M2 is a second metal binding moiety comprising a substituted oxazolone ring, and wherein M1 and M2 bind to a single metal atom. Also provided are related complexes, conjugates, cells which synthesize the compounds of the present disclosures, substantially homogenous cultures thereof, kits and compositions, and methods of making or using the materials of the present disclosures.
    Type: Application
    Filed: August 4, 2011
    Publication date: February 9, 2012
    Inventors: Jeremy D. Semrau, Warren Gallagher, Sukhwan Yoon, Jeongdae Im, Alan A. DiSpirito, Sung-Woo Lee, Scott Hartsel, Marcus T. McEllistrem
  • Patent number: 7199099
    Abstract: A means and method for treating bacterial infection, providing antioxidant activity, and chelating copper using a copper binding compound produced by methanotrophic bacteria is described. The compound, known as methanobactin, is the first of a new class of antibiotics having gram-positive activity. Methanobactin has been sequenced, and its structural formula determined.
    Type: Grant
    Filed: December 19, 2003
    Date of Patent: April 3, 2007
    Assignees: The University of Kansas, Iowa State University Research Foundation, Inc.
    Inventors: Alan A. DiSpirito, James A. Zahn, David W. Graham, Hyung J. Kim, Michail Alterman, Cynthia Larive
  • Publication number: 20040171519
    Abstract: A means and method for treating bacterial infection, providing antioxidant activity, and chelating copper using a copper binding compound produced by methanotrophic bacteria is described. The compound, known as methanobactin, is the first of a new class of antibiotics having gram-positive activity. Methanobactin has been sequenced, and its structural formula determined.
    Type: Application
    Filed: December 19, 2003
    Publication date: September 2, 2004
    Applicants: The University of Kansas, Iowa State University Research Foundation, Inc.
    Inventors: Alan A. DiSpirito, James A. Zahn, David W. Graham, Hyung J. Kim, Michail Alterman, Cynthia Larive
  • Patent number: 6489156
    Abstract: A Rhodobacter species and variants thereof are provided for odor remediation of anaerobic livestock waste lagoons. Also provided are vector systems and genetically reconstituted Rhodobacter PS9 cells, and related methods for biomass production in anaerobic livestock waste lagoons.
    Type: Grant
    Filed: May 5, 2000
    Date of Patent: December 3, 2002
    Assignee: Iowa State University Research Foundation, Inc.
    Inventors: Alan A. DiSpirito, Young S. Do, Gregory J. Phillips, James A. Zahn
  • Patent number: 5898003
    Abstract: An odor collection station for a waste water lagoon with a buoyant housing having a top, open bottom, and opposite side and end walls. The housing having a U-shaped duct with an upper and lower passageway connected by a vertical passageway. Buoyant elements secured to the housing maintain the lower passageway at a level higher than the water surface. Compressed air forced through an inlet port of the lower passageway combines with odors that rise from the lagoon surface and are pumped through the vertical and upper passageway to an outlet port where odor components are contained, measured, and analyzed.
    Type: Grant
    Filed: June 20, 1997
    Date of Patent: April 27, 1999
    Assignee: Iowa State University Research Foundation, Inc.
    Inventors: Alan A. DiSpirito, James A. Zahn
  • Patent number: 5766551
    Abstract: The gas sample device structure has a housing with a continuous normally vertical sidewall, closed top and an open bottom. Buoyant elements are secured to the housing to maintain its vertical position in a body of liquid livestock waste. A normally closed compartment is located on the top of the housing. A partition is located within the closed compartment to divide it into first and second subcompartments. An opening is provided in the closed top of the housing to allow gases from liquid manure in the housing to move into the first subcompartment. One or more hollow gas detection tubes are mounted in the second subcompartment and have a first open end in communication with the interior of the first subcompartment to receive gases from within the first compartment. The method of the invention involves placing the housing in a liquid manure lagoon so its buoyancy is maintained by the buoyancy elements, but the lower portion thereof is submerged in the liquid manure.
    Type: Grant
    Filed: June 26, 1996
    Date of Patent: June 16, 1998
    Assignee: Iowa State University Research Foundation, Inc.
    Inventors: Alan A. DiSpirito, James A. Zahn