Patents by Inventor Alan A. Figler

Alan A. Figler has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • SIRNAS TARGETING SLC10A1 TRANSCRIPTS, COMPOSITIONS AND USES THEREOF
    Publication number: 20240254485
    Abstract: The present invention relates to siRNA molecules targeting a SLC10A1 mRNA transcript and methods of using the siRNA compositions for treatment of a NTCP associated disorder.
    Type: Application
    Filed: January 12, 2024
    Publication date: August 1, 2024
    Inventors: Ryan Feaver, Brian Johns, Jennifer Marks, Emile Velthuisen, Maria Sol Collado, Robert Alan Figler
  • Method to treat sickle cell disease
    Patent number: 8178509
    Abstract: The present invention provides a therapeutic method for treating an inflammatory response caused by a sickle cell crisis, comprising administration of an effective amount of an A2A adenosine receptor agonist. Optionally, the method includes administration of a type IV PDE inhibitor (e.g., rolipram).
    Type: Grant
    Filed: February 9, 2007
    Date of Patent: May 15, 2012
    Assignee: University of Virginia Patent Foundation
    Inventors: Joel M. Linden, Kori Wallace, Robert Alan Figler, Jayson M. Rieger
  • 2-propynyl adenosine analogs having A2A agonist activity and compositions thereof
    Patent number: 8158604
    Abstract: The invention provides compounds having the following general formula (I): wherein X, R1, R2, R7 and Z are as described here.
    Type: Grant
    Filed: February 24, 2010
    Date of Patent: April 17, 2012
    Assignee: University of Virginia Patent Foundation
    Inventors: Joel M. Linden, Jayson M. Rieger, Timothy L. Macdonald, Gail W. Sullivan, Lauren J. Murphree, Robert Alan Figler
  • 2-propynyl adenosine analogs with modified 5?-ribose groups having A2A agonist activity
    Patent number: 7989431
    Abstract: The invention provides compounds having the following general formula (I): wherein X, R1, R2, R7 and Z are as described herein.
    Type: Grant
    Filed: June 18, 2009
    Date of Patent: August 2, 2011
    Assignee: University of Virginia Patent Foundation
    Inventors: Jayson M. Rieger, Joel M. Linden, Timothy L. Macdonald, Gail W. Sullivan, Lauren J. Murphree, Robert Alan Figler
  • 2-PROPYNYL ADENOSINE ANALOGS WITH MODIFIED 5'-RIBOSE GROUPS HAVING A2A AGONIST ACTIVITY
    Publication number: 20110136755
    Abstract: The invention provides compounds having the following general formula (I): wherein X, R1, R2, R7 and Z are as described herein.
    Type: Application
    Filed: February 15, 2011
    Publication date: June 9, 2011
    Applicant: University of Virginia Patent Foundation
    Inventors: Jayson M. Rieger, Joel M. Linden, Timothy L. Macdonald, Gail W. Sullivan, Lauren J. Murphree, Robert Alan Figler
  • 2-polycyclic propynyl adenosine analogs having A2A agonist activity
    Patent number: 7875595
    Abstract: The invention provides compounds having the following general formula (I): wherein X, R1, R2, R7 and Z are as described herein.
    Type: Grant
    Filed: June 18, 2009
    Date of Patent: January 25, 2011
    Assignee: University of Virginia Patent Foundation
    Inventors: Jayson M. Rieger, Joel M. Linden, Timothy L. Macdonald, Gail W. Sullivan, Lauren J. Murphree, Robert Alan Figler, Robert Douglas Thompson
  • 2-PROPYNYL ADENOSINE ANALOGS HAVING A2A AGONIST ACTIVITY AND COMPOSITIONS THEREOF
    Publication number: 20100152127
    Abstract: The invention provides compounds having the following general formula (I): wherein X, R1, R2, R7 and Z are as described here.
    Type: Application
    Filed: February 24, 2010
    Publication date: June 17, 2010
    Applicant: University of Virginia Patent Foundation
    Inventors: Joel M. Linden, Jayson M. Rieger, Timothy L. Macdonald, Gail W. Sullivan, Lauren Jean Murphree, Robert Alan Figler
  • 2-propynyl adenosine analogs having A2A agonist activity and compositions thereof
    Patent number: 7737127
    Abstract: The invention provides compounds having the following general formula (I): wherein X, R1, R2, R7 and Z are as described here.
    Type: Grant
    Filed: March 26, 2007
    Date of Patent: June 15, 2010
    Assignee: University of Virginia Patent Foundation
    Inventors: Joel M. Linden, Jayson M. Rieger, Timothy L. Macdonald, Gail W. Sullivan, Lauren Jean Murphree, Robert Alan Figler
  • 2-POLYCYCLIC PROPYNYL ADENOSINE ANALOGS HAVING A2A AGONIST ACTIVITY
    Publication number: 20090298788
    Abstract: The invention provides compounds having the following general formula (I): wherein X, R1, R2, R7 and Z are as described herein.
    Type: Application
    Filed: June 18, 2009
    Publication date: December 3, 2009
    Inventors: Jayson M. Rieger, Joel M. Linden, Timothy L. Macdonald, Gail W. Sullivan, Lauren J. Murphree, Robert Alan Figler, Robert Douglas Thompson
  • 2-propynyl adenosine analogs with modified 5?-ribose groups having Aagonist activity
    Patent number: 7605143
    Abstract: The invention provides compounds having the following general formula (I): wherein X, R1, R2, R7 and Z are as described herein.
    Type: Grant
    Filed: August 2, 2005
    Date of Patent: October 20, 2009
    Assignee: University of Virginia Patent Foundation
    Inventors: Jayson M. Rieger, Joel M. Linden, Timothy L. Macdonald, Gail W. Sullivan, Lauren J. Murphree, Robert Alan Figler
  • 2-PROPYNYL ADENOSINE ANALOGS WITH MODIFIED 5'-RIBOSE GROUPS HAVING A2A AGONIST ACTIVITY
    Publication number: 20090253647
    Abstract: The invention provides compounds having the following general formula (I): wherein X, R1, R2, R7 and Z are as described herein.
    Type: Application
    Filed: June 18, 2009
    Publication date: October 8, 2009
    Inventors: Jayson M. Rieger, Jeol M. Linden, Timothy L. MacDonald, Gail W. Sullivan, Lauren J. Murphree, Robert Alan Figler
  • 2-polycyclic propynyl adenosine analogs having A2A agonist activity
    Patent number: 7576069
    Abstract: The invention provides compounds having the following general formula (I): wherein X, R1, R2, R7 and Z are as described herein.
    Type: Grant
    Filed: August 2, 2005
    Date of Patent: August 18, 2009
    Assignee: University of Virginia Patent Foundation
    Inventors: Jayson M. Rieger, Joel M. Linden, Timothy L. Macdonald, Gail W. Sullivan, Lauren J. Murphree, Robert Alan Figler, Robert Douglas Thompson
  • 2-polycyclic propynyl adenosine analogs having A2A agonist activity
    Patent number: 7442687
    Abstract: The invention provides compounds having the following general formula (I): wherein X, R1, R2, R7 and Z are as described herein.
    Type: Grant
    Filed: August 2, 2005
    Date of Patent: October 28, 2008
    Assignee: The University of Virginia Patent Foundation
    Inventors: Jayson M. Rieger, Joel M. Linden, Timothy L. Macdonald, Gail W. Sullivan, Lauren J. Murphree, Robert Alan Figler, Robert Douglas Thompson
  • 2-propynyl adenosine analogs having Aagonist activity and compositions thereof
    Patent number: 7214665
    Abstract: The invention provides compounds having the following general formula (I): wherein X, R1, R2, R7 and Z are as described here.
    Type: Grant
    Filed: October 1, 2002
    Date of Patent: May 8, 2007
    Assignee: University of Virginia Patent Foundation
    Inventors: Joel M. Linden, Jayson M. Rieger, Timothy L. Macdonald, Gail W. Sullivan, Lauren Jean Murphree, Robert Alan Figler
  • 2-propynyl adenosine analogs having A2A agonist activity and compositions thereof
    Publication number: 20030186926
    Abstract: The invention provides compounds having the following general formula (I): 1
    Type: Application
    Filed: October 1, 2002
    Publication date: October 2, 2003
    Inventors: Joel M. Linden, Jayson M. Rieger, Timothy L. MacDonald, Gail W. Sullivan, Lauren Jean Murphree, Robert Alan Figler
  • Systems and methods for testing pump flow rates
    Patent number: 5608650
    Abstract: The system and methods obtain a set of multiple data samples and derive an average of the data samples in the set (SET.sub.AVE). The systems and methods derive a standard deviation for the data samples in the set (SET.sub.STD). The systems and methods compare each of the data samples to SET.sub.STD and either reject the data sample, if the absolute difference between the data sample is greater than or equal to k * SET.sub.STD, where k is a selected value greater than zero, or retain the data sample, if the absolute difference between the data sample is less than k * SET.sub.STD. The systems and methods repeat the foregoing steps until the absolute difference between every data sample remaining in the set is less than k * SET.sub.STD. The systems and methods then derive a filtered average for the set FSET.sub.AVG, where FSET.sub.AVE is the SET.sub.AVG for the data set in which the absolute difference between every data sample remaining in the set is less than k * SET.sub.STD.
    Type: Grant
    Filed: August 19, 1994
    Date of Patent: March 4, 1997
    Assignee: Spectrel Partners, L.L.C.
    Inventors: Robert R. McClendon, Aleandro DiGianfilippo, Richard Pierce, Alan A. Figler
  • Apparatus and method for the detection of air in fluid delivery systems
    Patent number: 4981467
    Abstract: An infusion device includes an infusion pump for delivering a liquid through an infusion conduit from a separate source of the liquid into a patient, a bubble detector for detecting the presence of an air bubble in the infusion conduit, and control circuitry responsive to the bubble detector for determining if the size of the air bubble is unacceptable. The control circuitry is configured to determine if during the time the air bubble is detected it advances a distance indicative of the unacceptable size, one embodiment counting the steps of a linear peristaltic infusion pump for that purpose.
    Type: Grant
    Filed: February 27, 1990
    Date of Patent: January 1, 1991
    Assignee: Baxter International Inc.
    Inventors: Donald E. Bobo, Jr., Alan A. Figler, Jeffrey L. Frank
  • Compounding system
    Patent number: 4653010
    Abstract: The present invention provides a fast, efficient and precise method and apparatus for compounding a large number of solutions for use in hyperalimentation therapy. The apparatus includes a host computer which maintains a data base of prescriptions to be compounded, and a high speed compounding apparatus connected to the host computer for compounding mixtures of base solutions in response to information supplied by the host computer from the prescription data base.Information can be entered concerning patients or prescriptions through a video display tube into the host computer data base. The host computer also includes provisions for a library of prestored standard prescriptions which can be recalled and associated with a given patient. A group of prescriptions to be compounded is first sorted in accordance with the types of specified base solutions and optionally sorted again based on the concentration of base solutions.
    Type: Grant
    Filed: October 26, 1984
    Date of Patent: March 24, 1987
    Assignee: Baxter Travenol Laboratories, Inc.
    Inventors: Alan A. Figler, Aleandro DiGianfilippo
  • Device and method for collecting a desired weight amount of a material
    Patent number: 4648430
    Abstract: A method and apparatus of collecting a desired end-point weight amount of material first conveys the material into the collection container until a predetermined weight amount is collected. The predetermined weight amount is less than the desired end-point weight amount by a selected initial weight offset amount. An additional incremental amount of material is next conveyed into the container for a predetermined fixed time period. In doing so, the method and apparatus gauge the particular flow characteristics of the associated flow system. A further additional incremental amount of material is conveyed into the collection container for another time period, the length of which reflects the anticipated flow characteristics of the system, based upon the performance of the system during the preceding period. The method and apparatus repeat this sequence until the then-existing weight amount equals or exceeds the desired end-point weight amount.
    Type: Grant
    Filed: April 14, 1986
    Date of Patent: March 10, 1987
    Assignee: Baxter Travenol Laboratories, Inc.
    Inventors: Aleandro Di Gianfilippo, Alan A. Figler, Leon Huang, Donald Warner
  • Safety system for heating conduit
    Patent number: 4647219
    Abstract: A process is provided for detecting if a temperature sensor (18) is correctly located in a heating conduit at a point that is remote from the heater (28). Power is applied to the heater (28) in a predetermined manner. The change in the temperature sensed by the temperature sensor (18) is observed. If the temperature sensed by the temperature sensor (18) has changed in a certain manner, a signal is provided indicating that the temperature sensor (18) is located correctly. If, during observation, the temperature sensed has not changed in the certain manner, an alarm signal is provided.
    Type: Grant
    Filed: January 9, 1986
    Date of Patent: March 3, 1987
    Assignee: Baxter Travenol Laboratories, Inc.
    Inventors: Alan A. Figler, Daniel J. Grimm, Leonard F. Goloski, James P. Martucci