Abstract: Systems and methods including one or more processors and one or more non-transitory storage devices storing computing instructions configured to run on the one or more processors and perform: generating a mask of an object using one or more images; generating a 3D model of the object using the mask of the object; facilitating displaying a 3D display of the object on an electronic device of a user using the 3D model; receiving, from the electronic device of the user, a zoom selection on the 3D display of the object; in response to receiving the zoom selection, facilitating displaying a zoomed 3D display of the object on the electronic device of the user; receiving, from the electronic device of the user, a zoom rotation selection of the object in the zoomed 3D display; and in response to receiving the zoom rotation selection, facilitating rotating the 3D display of the object in the zoomed 3D display on the electronic device of the user. Other embodiments are disclosed herein.

Abstract: A system and related method are provided for draining cerebrospinal fluid from a bodily cavity of a patient, such as a ventricle in the brain in one application. The system includes a reservoir which may be a collapsible container configured for fluidic connection to a shunt located in the bodily cavity. The collapsible container may be an elastically deformable bladder in one embodiment. A pump is fluidly connected to the collapsible container and draws cerebrospinal fluid therefrom. A programmable controller directs the pump to repeatedly activate and deactivate at a predetermined time interval. A plurality of sensors may be provided which are communicably coupled to the controller for monitoring pump motor current draw, tension in the resilient body of the container, pressure, and orientation of the patient. The controller is configurable to deactivate the pump when abnormal operating conditions are detected by the sensors.

Abstract: Rotor noise cancellation through the use of mechanical means for a personal aerial drone vehicle. Active noise cancellation is achieved by creating an antiphase amplitude wave by modulation of the propeller blades, by utilizing embedded magnets through an electromagnetic coil encircling the propeller blades. A noise level sensor signals the rotor control system to adjust the frequency of the electromagnetic field surrounding the rotor and control the speed of the rotor. An additional method comprises of incorporating a phase lock loop within the control system configured to determine the frequencies corresponding to the rotors and generate corrective audio signals to achieve active noise cancellation.

Abstract: A refrigeration evaporator for use in refrigeration systems, the evaporator comprising: a plurality of fluidly connected liquid chambers disposed between first and second layers of material, an inlet for receiving and introducing liquid refrigerant into at least one of said plurality of liquid chambers; and wherein each of the liquid chambers are interconnected by respective overflow inlets and outlets to allow flow of liquid refrigerant between the plurality of fluidly connected liquid chambers under gravity such during influent flow of the refrigerant liquid through the inlet, the liquid chambers accumulate the refrigerant liquid sequentially to impede the flow of the refrigerant liquid; and a vapour circuit comprising respective draw off vapour channels being provided to receive flow of refrigerant vapour from corresponding liquid chambers, the draw off vapour channels being in fluid communication with peripheral vapour channels disposed along peripheral regions of the evaporator for reducing or preventing

Abstract: Provided include materials and methods for treating Hemophilia A in a subject ex vivo or in vivo. Also provided include materials and methods for knocking in a FVIII-encoding gene in a genome, in particular the locus of albumin gene.

Abstract: The present invention provides a lubricant composition comprising: (i) a base oil (ii) an organophilic clay-based thickener; and (iii) a solid lubricant, wherein said solid lubricant does not comprise any heavy metals. The present invention also provides the use of a lubricant composition comprising: a base oil; an organophilic clay-based thickener; and a solid lubricant, wherein said solid lubricant does not comprise any heavy metals, as a pipe dope.

Abstract: The present invention relates to drinking straws that are made from biodegradable material or bioplastics. The process to manufacture the present invention can use waste lipid wax byproducts. The present invention can incorporate chemical modification of corn or hemp fiber waste, and is comprised of wax byproduct, xanthan gum, carnauba wax and stearic acid. Stearin, hardener and plasticizers are mixed with corn or soy wax. A binder ingredient can be added to the waxes and fiber mixture, resulting in a smooth and hard, durable and biodegradable material with a high melting point. This material is then processed using an extrusion method, whereby the mixed ingredients are forced through an opening in a perforated plate or die with a design specific to form a straw, and then cut into a specific size by blades. The extruder consists of a large, rotating screw tightly fitting within a stationary barrel, at the end of which is the die.

Abstract: Provided herein are compositions, methods, and systems for targeted delivery of nucleic acids, including DNA and RNA, to a target cell. Also provided are compositions, methods, and systems for expressing a transgene in a cell by genomic editing. Further provided are compositions, methods, and systems for knocking in a gene-of-interest (GOI) into a target genomic locus in the genome, in particular the locus of albumin gene. Also provided are compositions, methods, and systems for treating a subject having or suspected of having a disorder or health condition employing ex vivo and/or in vivo genome editing.

Abstract: Rotor noise cancellation through the use of mechanical means for a personal aerial drone vehicle. Active noise cancellation is achieved by creating an antiphase amplitude wave by modulation of the propeller blades, by utilizing embedded magnets through an electromagnetic coil encircling the propeller blades. A noise level sensor signals the rotor control system to adjust the frequency of the electromagnetic field surrounding the rotor and control the speed of the rotor. An additional method comprises of incorporating a phase lock loop within the control system configured to determine the frequencies corresponding to the rotors and generate corrective audio signals to achieve active noise cancellation.

Abstract: Provided include compositions, methods, and systems for modulating the expression, function, and/or activity of a target gene, for example a blood-clotting protein such as Factor VIII (FVIII), in a cell by genome editing. Also provided include compositions, methods, and systems for treating a subject having or suspected of having a disorder or health condition, e.g., Hemophilia A, employing ex vivo and/or in vivo genome editing.

Abstract: The present invention is a portable air horn apparatus including: a housing; an air horn assembly for generating sound, the air horn being mounted in the housing and receiving air from a small tank. An internal pump fills a small inline tank by means of a one way valve, and a release button sends the air through a diaphragm through the air horn. The air supply of the inline tank is rechargeable by means of an internal hand operated pump, in order to maintain the necessary supply of air required to produce adequate sound.

Abstract: Provided include materials and methods for treating Hemophilia A in a subject ex vivo or in vivo. Also provided include materials and methods for knocking in a FVIII-encoding gene in a genome, in particular the locus of albumin gene.

Abstract: Rotor noise cancellation through the use of mechanical means for a personal aerial drone vehicle. Active noise cancellation is achieved by creating an antiphase amplitude wave by modulation of the propeller blades, by utilizing embedded magnets through an electromagnetic coil encircling the propeller blades. A noise level sensor signals the rotor control system to adjust the frequency of the electromagnetic field surrounding the rotor and control the speed of the rotor. An additional method comprises of incorporating a phase lock loop within the control system configured to determine the frequencies corresponding to the rotors and generate corrective audio signals to achieve active noise cancellation.

Abstract: Provided include compositions, methods, and systems for modulating the expression, function, and/or activity of a target gene, for example a blood-clotting protein such as Factor VIII (FVIII), in a cell by genome editing. Also provided include compositions, methods, and systems for treating a subject having or suspected of having a disorder or health condition, e.g., hemophilia A, employing ex vivo and/or in vivo genome editing.

Abstract: The invention relates to processes for preparing isoindolin-1-one derivatives, and in particular processes for preparing (2S,3S)-3-(4-chlorophenyl)-3-[(1R)-1-(4-chlorophenyl)-7-fluoro-5-[(1S)-1-hydroxy-1-(oxan-4-yl)propyl]-1-methoxy-3-oxo-2,3-dihydro-1H-isoindol-2-yl]-2-methylpropanoic acid. The invention also relates to crystalline forms of the compound (2S,3S)-3-(4-chlorophenyl)-3-[(1R)-1-(4-chlorophenyl)-7-fluoro-5-[(1S)-1-hydroxy-1-(oxan-4-yl)propyl]-1-methoxy-3-oxo-2,3-dihydro-1H-isoindol-2-yl]-2-methylpropanoic acid and its salts.

Abstract: Rotor noise cancellation through the use of mechanical means for a personal aerial drone vehicle. Active noise cancellation is achieved by creating an antiphase amplitude wave by modulation of the propeller blades, by utilizing embedded magnets through an electromagnetic coil encircling the propeller blades. A noise level sensor signals the rotor control system to adjust the frequency of the electromagnetic field surrounding the rotor and control the speed of the rotor. An additional method comprises of incorporating a phase lock loop within the control system configured to determine the frequencies corresponding to the rotors and generate corrective audio signals to achieve active noise cancellation.

Abstract: Provided herein, in some embodiments, are materials and methods for treating hemophilia A in a subject ex vivo or in vivo. Also provided herein, in some embodiments, are materials and methods for knocking in a coding sequence encoding a synthetic FVIII having a B domain substitute into a genome.

Abstract: A grease composition comprises a base oil and an aluminium complex soap thickener, with graphite, molybdenum di-sulphide, calcium carbonate and bismuth sulphide all included as additives. The composition exhibits advantageous load, wear and friction performance, especially in extreme pressure environments, and is particularly suitable for use on open gears.

Abstract: A sensing structure for an accelerometer includes a support and a proof mass mounted to the support by flexible legs for in-plane movement in response to an applied acceleration along a sensing direction. The proof mass includes a plurality of moveable electrode fingers extending substantially perpendicular to the sensing direction and spaced apart in the sensing direction. The structure also includes at least one pair of fixed capacitor electrodes comprising first and second sets of fixed electrode fingers extending substantially perpendicular to the sensing direction and spaced apart in the sensing direction; the first set of fixed electrode fingers arranged to interdigitate with the moveable electrode fingers with a first offset in one direction from a median line therebetween, and the second set of fixed electrode fingers arranged to interdigitate with the moveable electrode fingers with a second offset in the opposite direction from a median line therebetween.

Abstract: Provided include materials and methods for treating Hemophilia A in a subject ex vivo or in vivo. Also provided include materials and methods for knocking in a FVIII-encoding gene in a genome, in particular the locus of albumin gene.