Abstract: The invention relates to the use of chiral sulfamic acids as resolving agents, the sulfamic acid having the formula (R1,R2)N—SO3H, wherein: R1 and R2, being the same or different, represent a hydrogen atom or a C1-C30 linear, branched or cyclic (hetero)-aliphatic or (hetero)-aromatic group, provided that R1 and R2 are not both hydrogen and that at least one of the R1 and R2 groups is chiral. Further, methods for resolving enantiomeric mixtures are disclosed.

Abstract: A method of determining the optimal yield of a target compound includes the steps of: (a) determining the initial composition of a mixture of compounds containing the target compound; (b) dissolving the mixture in a solvent; (c) placing a quantity of the solution in a plurality of vessels; (d) optionally, placing a portion of a different derivatising agent in each vessel; (e) causing crystallisation to occur; (f) analysing the contents of the vessels after the crystallisation has approached equilibrium to determine the compositions of the liquors and the compositions of the solids; and (g) comparing the compositions determined in step (f) to profile the performance of each system in terms of the projected maximum yield of target compound is an optimised crystallisation process.

Abstract: The invention relates to the use of chiral sulfamic acids as resolving agents, the sulfamic acid having the formula (R1, R2?) N—SO3H, ?wherein: R1 and R2, ?being the same or different, represent a hydrogen atom or a C1-C30 linear, branched or cyclic (hetero)-aliphatic or (hetero)-aromatic group, provided that R1 ?and R2 are not both hydrogen and that at least one of the R1 and R2 groups is chiral. Further, methods for resolving enantiomeric mixtures are disclosed.

Abstract: A method of determining the optimal yield of a target compound comprises: (a) determining the initial composition of a mixture of compounds containing the target compound; (b) dissolving the mixture in a solvent; (c) placing a quantity of the solution in a plurality of vessels; (d) optionally, placing a portion of a different derivatising agent in each vessel; (e) causing crystallisation to occur; (f) analysing the contents of the vessels after the crystallisation has approached equilibrium to determine the compositions of the liquors and the compositions of the solids; and (g) comparing the compositions determined in step (f) to profile the performance of each system (by calculated means) in terms of the projected maximum yield of target compound is an optimised crystallisation process.