Abstract: Methods and compositions for treating cancer are described herein. More particularly, the methods for treating cancer comprise administering a vitamin D compound in combination with at least one additional therapeutic agent, such as an anti-cancer agent or a steroid. Furthermore, disclosed are compositions comprising vitamin D compounds and at least one additional therapeutic agent, such as an anti-cancer agent or a steroid, e.g., corticosteroid or more specifically, a glucocorticoid.

Abstract: Methods and compositions for treating cancer are described herein. More particularly, the methods for treating cancer comprise administering a 17?-hydroxylase/C17,20-lyase inhibitor, such as abiraterone acetate (i.e., 3?-acetoxy-17-(3-pyridyl)androsta-5,16-diene), in combination with at least one additional therapeutic agent such as an anti-cancer agent or a steroid. Furthermore, disclosed are compositions comprising a 17?-hydroxylase/C17,20-lyase inhibitor, and at least one additional therapeutic agent, such as an anti-cancer agent or a steroid.

Abstract: A system for sampling raw data from a reporting application and segmenting portions of the sampled data into at least one of a set of raw data stores. The system enables ad hoc querying to be done against a data warehouse using the set of raw data stores and in conjunction with an aggregate store. A reporting aspect of the system is responsible for locating the appropriate store when responding to a query. The system also segments data based on anticipated usage of the raw data and appropriately places them into a raw data store having an access speed that corresponds to the anticipated usage level of the data.

Abstract: Disclosed are methods usable by non-experts for altering a configuration of a data warehouse. The initial configuration of the data warehouse is represented in terms of metadata, and that metadata configuration is presented to a user. The user can choose to alter the metadata configuration. If alterations are made to the metadata, then the underlying configuration of the data warehouse is altered accordingly. Because there may be multiple users wishing to alter aspects of the data warehouse, some embodiments of the present invention enforce approval guidelines so that proposed changes to the data warehouse configuration are only implemented after the appropriate approvals have been secured. By presenting a metadata representation of the data warehouse configuration, the present invention both allows non-experts to have a hand in converting a data warehouse and prevents user errors from corrupting the data warehouse conversion process.

Abstract: Disclosed are methods usable by non-experts for altering a configuration of a data warehouse. The initial configuration of the data warehouse is represented in terms of metadata, and that metadata configuration is presented to a user. The user can choose to alter the metadata configuration. If alterations are made to the metadata, then the underlying configuration of the data warehouse is altered accordingly. Because there may be multiple users wishing to alter aspects of the data warehouse, some embodiments of the present invention enforce approval guidelines so that proposed changes to the data warehouse configuration are only implemented after the appropriate approvals have been secured. By presenting a metadata representation of the data warehouse configuration, the present invention both allows non-experts to have a hand in converting a data warehouse and prevents user errors from corrupting the data warehouse conversion process.

Abstract: The present invention relates it directed to configurable collection of computer related metric data. A computer system generates computer related metric data related to an application. The application accesses a manifest that indicates a portion of the generated computer related metric data (e.g., a subset) is to be packaged for delivery. The application sends schema-based package start data to cause the portion of generated computer related metric data to be packaged. A quality metric module receives the schema-based package start data and accesses the indicated portion of computer related metric data. The quality metric module packages the portion of computer related metric data according to a packaging schema. The application sends a package send command to cause the packaged portion of computer related metric data to be delivered. The quality metric module receives the package send command and sends the packaged portion of computer related metric data in response to the package send command.