Patents by Inventor Alan Blanchard
Alan Blanchard has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240102912Abstract: Method and apparatus for performing a plaque counting assay of cultured cell by using a time sequence of images to identify plaques.Type: ApplicationFiled: November 9, 2021Publication date: March 28, 2024Applicant: Thrive Bioscience, Inc.Inventors: Alan BLANCHARD, Kenneth W. CHAPMAN
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Publication number: 20240101949Abstract: A method and apparatus for preventing condensation on a cell culture plate transferred from an incubator to an imager. A block having a higher thermal conductivity layer and a lower thermal conductivity layer is preheated in an incubator. The block is placed on a cell culture plate either before or immediately after removing the cell culture plate from an incubator with the higher thermal conductivity layer resting on the plate and configured to overlie all of the wells of the plate. The culture plate is transported to an imager with the thermal block in place and the block is removed before inserting the culture plate into the imager.Type: ApplicationFiled: December 15, 2021Publication date: March 28, 2024Applicant: THRIVE BIOSCIENCE, INC.Inventors: Alan BLANCHARD, Jeff GOLDMAN
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Patent number: 11920122Abstract: A cell culture incubator with an incubator cabinet has an internal chamber with a door opening from an external environment. An imager and a manipulator with a scraper are in the internal chamber. A controller is configured for controlling the manipulator to modulate the contact pressure between a scraping edge of the cell scraper and a surface of a cell culture vessel and a sensor is connected to the cell scraper that provides signal to the controller informative of a sensed pressure between a scraping edge of the cell scraper and the surface of a cell culture vessel. The controller controls the manipulator to increase or decrease the pressure between a scraping edge of the cell scraper and the surface of a cell culture vessel.Type: GrantFiled: April 12, 2022Date of Patent: March 5, 2024Assignee: Thrive Bioscience, Inc.Inventor: Alan Blanchard
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Patent number: 11920121Abstract: Aspects relate to an automated cell culture incubator and to methods for using such an incubator. In one aspect, the cell culture incubator includes an incubator cabinet having a transfer chamber and an internal chamber that are arranged to form an airlock configuration. In some embodiments, objects placed into the incubator cabinet are sterilized using ozone produced by an ozone generator. The incubator may include one or more transfer devices that move objects between the transfer chamber and the internal chamber.Type: GrantFiled: March 7, 2022Date of Patent: March 5, 2024Assignee: Thrive Bioscience, Inc.Inventor: Alan Blanchard
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Publication number: 20240067913Abstract: At least one tool removably mountable on a cell incubator mandrel or a cell incubator having at least one mandrel having an end portion, the at least one mandrel mounted on a movable transport for moving the at least one mandrel and at the least one tool removably mountable on the end portion of the at least one mandrel. The at least one tool is preferably electrically powered and controllable by signals applied to the at least one tool to perform at least one operation with respect to the incubation of cells.Type: ApplicationFiled: November 8, 2023Publication date: February 29, 2024Applicant: THRIVE BIOSCIENCE, INC.Inventor: Alan BLANCHARD
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Patent number: 11879120Abstract: In some aspects, the invention relates to automated cell culture incubators and their methods of use. In one aspect, the disclosure provides cell culture incubators having an airlock chamber, a storage chamber and/or an internal chamber. In some aspects, the disclosure provides methods for producing autologous mammalian cell cultures.Type: GrantFiled: September 30, 2021Date of Patent: January 23, 2024Assignee: Thrive Bioscience, Inc.Inventor: Alan Blanchard
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Publication number: 20230407391Abstract: A method of conjugating a substrate includes exchanging a counter ion associated with a biomolecule with a lipophilic counter ion to form a biomolecule complex, dispersing the biomolecule complex in a nonaqueous solvent, and coupling the biomolecule complex to a substrate in the presence of the nonaqueous solvent.Type: ApplicationFiled: June 14, 2023Publication date: December 21, 2023Inventors: Steven M. MENCHEN, Alan BLANCHARD, Luisa ANDRUZZI, Shaheer KHAN, Dmitriy GREMYACHINSKIY, Alfred LUI, Craig STOLARCZYK, Tanya SOKOLSKY, Prasanna Krishnan THWAR
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Patent number: 11845922Abstract: At least one tool removably mountable on a cell incubator mandrel or a cell incubator having at least one mandrel having an end portion, the at least one mandrel mounted on a movable transport for moving the at least one mandrel and at the least one tool removably mountable on the end portion of the at least one mandrel. The at least one tool is preferably electrically powered and controllable by signals applied to the at least one tool to perform at least one operation with respect to the incubation of cells.Type: GrantFiled: July 3, 2018Date of Patent: December 19, 2023Assignee: THRIVE BIOSCIENCE, INC.Inventor: Alan Blanchard
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Publication number: 20230351602Abstract: Methods for the image processing od cells are disclosed for the purpose of segmenting cell colonies for further processing to determine confluence, counting and morphology.Type: ApplicationFiled: August 13, 2021Publication date: November 2, 2023Applicant: Thrive Bioscience, Inc.Inventors: Alan BLANCHARD, Kenneth W. CHAPMAN, Christian D. CHAPMAN, Frank EVANS
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Publication number: 20230321647Abstract: Aspects of the invention relate to liquid transfer systems including a pipette tip having a body defining an inner volume and having first and second ends, the first end arranged to transfer a volume of liquid into and out of the pipette tip and the second end arranged for attachment to a pipette, and a bladder sealingly attached to the body. In some embodiments, the bladder is disposable in the inner volume. The bladder may be defined by a membranous sac and/or a planar membrane. The bladder may be moveable in response to an applied pressure to transfer liquid. The bladder also may be stretchable to accommodate a volume of fluid. In some embodiments, the pipette tip is used in a cell culture incubator, with a manipulator including a pipette that is in fluid communication with the pipette tip.Type: ApplicationFiled: June 12, 2023Publication date: October 12, 2023Applicant: Thrive Bioscience, Inc.Inventor: Alan Blanchard
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Publication number: 20230303959Abstract: A method and apparatus for incubating sperm, eggs, and/or embryos for in vitro fertilization placing at least one of sperm, eggs, and embryos in at least one cell culture vessel in an incubator chamber having windows with filters to filter out ultraviolet light, wherein interior surfaces of the chamber comprises material that prevents the growth of fungus, and wherein the chamber includes sensors for regulating the levels of oxygen, carbon dioxide and nitrogen in the chamber, transporting the at least one cell culture vessel from a storage location in the chamber to an imager at an imaging location in the chamber using an elevator; and repeatedly imaging at least one of the sperm, eggs, and the embryos in the imager while maintaining the levels of oxygen, carbon dioxide and nitrogen throughout the chamber.Type: ApplicationFiled: May 31, 2023Publication date: September 28, 2023Applicant: Thrive Bioscience, Inc.Inventor: Alan Blanchard
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Patent number: 11724254Abstract: Aspects of the invention relate to liquid transfer systems including a pipette tip having a body defining an inner volume and having first and second ends, the first end arranged to transfer a volume of liquid into and out of the pipette tip and the second end arranged for attachment to a pipette, and a bladder sealingly attached to the body. In some embodiments, the bladder is disposable in the inner volume. The bladder may be defined by a membranous sac and/or a planar membrane. The bladder may be moveable in response to an applied pressure to transfer liquid. The bladder also may be stretchable to accommodate a volume of fluid. In some embodiments, the pipette tip is used in a cell culture incubator, with a manipulator including a pipette that is in fluid communication with the pipette tip.Type: GrantFiled: May 18, 2018Date of Patent: August 15, 2023Assignee: Thrive Bioscience, Inc.Inventor: Alan Blanchard
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Patent number: 11702696Abstract: A method of conjugating a substrate includes exchanging a counter ion associated with a biomolecule with a lipophilic counter ion to form a biomolecule complex, dispersing the biomolecule complex in a nonaqueous solvent, and coupling the biomolecule complex to a substrate in the presence of the nonaqueous solvent.Type: GrantFiled: July 24, 2020Date of Patent: July 18, 2023Assignee: LIFE TECHNOLOGIES CORPORATIONInventors: Steven M. Menchen, Alan Blanchard, Luisa Andruzzi, Shaheer Khan, Dmitriy Gremyachinskiy, Alfred Lui, Craig Stolarczyk, Tanya Sokolsky, Prasanna Krishnan Thwar
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Publication number: 20230105170Abstract: A method for pre-scanning a transparent cell culture plate with a plurality of wells to improve focus using a plurality of z-axis images and a method for focusing an optical system on a transparent cell culture plate by performing a Fourier transform on image data at different focus distance steps to reveal a pattern and using the pattern at each step to determine the focus distance.Type: ApplicationFiled: February 26, 2021Publication date: April 6, 2023Applicant: Thrive Bioscience, Inc.Inventors: Jeff GOLDMAN, Alan BLANCHARD
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Publication number: 20220403314Abstract: Aspects of the invention relate to cell culture vessels and method for using the vessels to agitate and maintain cells in suspension. In some embodiments, the vessel has a body configured to hold a volume of liquid containing cells to be cultured, the vessel body having a deformable portion arranged to induce movement of the liquid sufficient to maintain the cells in suspension. In some embodiments, the deformable portion is in at least one of a base and sidewall of the vessel body. In some embodiments, the deformable portion is deformed according to a deformable pattern. In some embodiments, the deformable portion is deformed via a deformation plate having one or more movable members that contact the deformable portion.Type: ApplicationFiled: August 18, 2022Publication date: December 22, 2022Applicant: Thrive Bioscience, Inc.Inventor: Alan Blanchard
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Publication number: 20220259546Abstract: Aspects relate to an automated cell culture incubator and to methods for using such an incubator. In one aspect, the cell culture incubator includes an incubator cabinet having a transfer chamber and an internal chamber that are arranged to form an airlock configuration. In some embodiments, objects placed into the incubator cabinet are sterilized using ozone produced by an ozone generator. The incubator may include one or more transfer devices that move objects between the transfer chamber and the internal chamber.Type: ApplicationFiled: March 7, 2022Publication date: August 18, 2022Applicant: Thrive Bioscience, Inc.Inventor: Alan Blanchard
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Publication number: 20220243167Abstract: Aspects of the invention relate to automated cell culture incubators. In some embodiments, automated cell culture incubators comprise an integrated manipulation device having one or more cell scrapers.Type: ApplicationFiled: April 12, 2022Publication date: August 4, 2022Applicant: Thrive Bioscience, Inc.Inventor: Alan Blanchard
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Patent number: 11332705Abstract: Aspects of the invention relate to automated cell culture incubators. In some embodiments, automated cell culture incubators comprise an integrated manipulation device having one or more cell scrapers.Type: GrantFiled: May 14, 2020Date of Patent: May 17, 2022Assignee: Thrive Bioscience, Inc.Inventor: Alan Blanchard
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Patent number: 11319523Abstract: Aspects relate to an automated cell culture incubator and to methods for using such an incubator. In one aspect, the cell culture incubator includes an incubator cabinet having a transfer chamber and an internal chamber that are arranged to form an airlock configuration. In some embodiments, objects placed into the incubator cabinet are sterilized using ozone produced by an ozone generator. The incubator may include one or more transfer devices that move objects between the transfer chamber and the internal chamber.Type: GrantFiled: March 31, 2016Date of Patent: May 3, 2022Assignee: Thrive Bioscience, Inc.Inventor: Alan Blanchard
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Publication number: 20220089997Abstract: In some aspects, the invention relates to automated cell culture incubators and their methods of use. In one aspect, the disclosure provides cell culture incubators having an airlock chamber, a storage chamber and/or an internal chamber. In some aspects, the disclosure provides methods for producing autologous mammalian cell cultures.Type: ApplicationFiled: September 30, 2021Publication date: March 24, 2022Applicant: Thrive Bioscience, Inc.Inventor: Alan Blanchard