Patents by Inventor Alan Brash

Alan Brash has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Muskmelon () hydroperoxide lyase and uses thereof
    Patent number: 7037693
    Abstract: The present invention provides a fatty acid lyase, wherein the activity of the lyase for 9-hydroperoxide substrates is greater than the activity for 13-hydroperoxide substrates and wherein Km and Vmax of the lyase for 9-hydroperoxylinolenic acid are greater than Km and Vmax of the lyase for 9-hydroperoxylinoleic acid. More particularly, the invention provides a lyase present in melon (Cucumis melo). The invention also provides a nucleic acid encoding the lyase, vectors, and expression systems with which the recombinant lyase can be obtained. The invention also provides methods of using the lyase of the invention, including methods of cleaving 9-hydroperoxylinoleic acid, 9-hydroperoxylinolenic acid, 13-hydroperoxylinoleic acid, and 13-hydroperoxylinolenic acid.
    Type: Grant
    Filed: June 19, 2001
    Date of Patent: May 2, 2006
    Assignees: Vanderbilt University, Firmenich SA
    Inventors: Alan Brash, Nathalie Tijet, Ian M. Whitehead
  • Muskmelon (Cucumis melo) hydroperoxide lyase and uses thereof
    Publication number: 20020098570
    Abstract: The present invention provides a fatty acid lyase, wherein the activity of the lyase for 9-hydroperoxide substrates is greater than the activity for 13-hydroperoxide substrates and wherein Km and Vmax of the lyase for 9-hydroperoxylinolenic acid are greater than Km and Vmax of the lyase for 9-hydroperoxylinoleic acid. More particularly, the invention provides a lyase present in melon (Cucumis melo). The invention also provides a nucleic acid encoding the lyase, vectors, and expression systems with which the recombinant lyase can be obtained. The invention also provides methods of using the lyase of the invention, including methods of cleaving 9-hydroperoxylinoleic acid, 9-hydroperoxylinolenic acid, 13-hydroperoxylinoleic acid, and 13-hydroperoxylinolenic acid.
    Type: Application
    Filed: June 19, 2001
    Publication date: July 25, 2002
    Applicant: VANDERBILT UNIVERSITY
    Inventors: Alan Brash, Nathalie Tijet, Ian M. Whitehead
  • Muskmelon (Cucumis melo) hydroperoxide lyase and uses thereof
    Patent number: 6271018
    Abstract: The present invention provides a fatty acid lyase, wherein the activity of the lyase for 9-hydroperoxide substrates is greater than the activity for 13-hydroperoxide substrates and wherein Km and Vmax of the lyase for 9-hydroperoxylinolenic acid are greater than Km and Vmax of the lyase for 9-hydroperoxylinoleic acid. More particularly, the invention provides a lyase present in melon (Cucumis melo). The invention also provides a nucleic acid encoding the lyase, vectors, and expression systems with which the recombinant lyase can be obtained. The invention also provides methods of using the lyase of the invention, including methods of cleaving 9-hydroperoxylinoleic acid, 9-hydroperoxylinolenic acid, 13-hydroperoxylinoleic acid, and 13-hydroperoxylinolenic acid.
    Type: Grant
    Filed: March 29, 2000
    Date of Patent: August 7, 2001
    Assignees: Vanderbilt University, Firmenich SA
    Inventors: Alan Brash, Nathalie Tijet, Ian M. Whitehead