Patents by Inventor Alan Brooks

Alan Brooks has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • SUPPLEMENTATION OF LIVER ENZYME EXPRESSION
    Publication number: 20260115320
    Abstract: Described herein are methods, compositions, and systems derived from uncultivated microorganisms useful supplementing liver enzyme deficiencies.
    Type: Application
    Filed: December 23, 2025
    Publication date: April 30, 2026
    Inventors: Brian C. Thomas, Alan Brooks
  • SUPPLEMENTATION OF LIVER ENZYME EXPRESSION
    Publication number: 20260115319
    Abstract: Described herein are methods, compositions, and systems derived from uncultivated microorganisms useful supplementing liver enzyme deficiencies.
    Type: Application
    Filed: December 23, 2025
    Publication date: April 30, 2026
    Inventors: Brian C. Thomas, Alan Brooks
  • SUPPLEMENTATION OF LIVER ENZYME EXPRESSION
    Publication number: 20260115321
    Abstract: Described herein are methods, compositions, and systems derived from uncultivated microorganisms useful supplementing liver enzyme deficiencies.
    Type: Application
    Filed: December 23, 2025
    Publication date: April 30, 2026
    Inventors: Brian C. Thomas, Alan Brooks
  • Supplementation of liver enzyme expression
    Patent number: 12533424
    Abstract: Described herein are methods, compositions, and systems derived from uncultivated microorganisms useful supplementing liver enzyme deficiencies.
    Type: Grant
    Filed: November 25, 2024
    Date of Patent: January 27, 2026
    Assignee: Metagenomi, Inc.
    Inventors: Brian C. Thomas, Alan Brooks
  • Base editing enzymes
    Patent number: 12503710
    Abstract: The present disclosure provides for endonuclease enzymes having distinguishing domain features, as well as methods of using such enzymes or variants thereof.
    Type: Grant
    Filed: May 2, 2024
    Date of Patent: December 23, 2025
    Assignee: Metagenomi, Inc.
    Inventors: Brian C. Thomas, Jyun-Liang Lin, Alan Brooks, Cristina Butterfield, Christopher Brown, Cindy Castelle, Morayma Temoche-Diaz, Benjamin Freeman, Christine Romano, Rebecca Lamothe
  • SUPPLEMENTATION OF LIVER ENZYME EXPRESSION
    Publication number: 20250161491
    Abstract: Described herein are methods, compositions, and systems derived from uncultivated microorganisms useful supplementing liver enzyme deficiencies.
    Type: Application
    Filed: November 25, 2024
    Publication date: May 22, 2025
    Inventors: Brian C. Thomas, Alan Brooks
  • Base editing enzymes
    Patent number: 12286654
    Abstract: The present disclosure provides for endonuclease enzymes having distinguishing domain features, as well as methods of using such enzymes or variants thereof.
    Type: Grant
    Filed: June 15, 2022
    Date of Patent: April 29, 2025
    Assignee: Metagenomi, Inc.
    Inventors: Jyun-Liang Lin, Alan Brooks, Cristina Butterfield, Christopher Brown, Cindy Castelle, Brian C. Thomas
  • CLASS II, TYPE V CRISPR SYSTEMS
    Publication number: 20250059568
    Abstract: Described herein are methods, compositions, and systems derived from uncultivated microorganisms useful for gene editing.
    Type: Application
    Filed: August 27, 2024
    Publication date: February 20, 2025
    Inventors: Brian THOMAS, Christopher BROWN, Audra DEVOTO, Cristina BUTTERFIELD, Lisa ALEXANDER, Daniela S.A. GOLTSMAN, Justine ALBERS, Alan BROOKS, Greg COST, Morayma TEMOCHE-DIAZ, Cindy CASTELLE, Rebecca LAMOTHE
  • ENGINEERED AND CHIMERIC NUCLEASES
    Publication number: 20250002886
    Abstract: Disclosed herein are engineered nucleases and nuclease systems, including chimeric nucleases and chimeric nuclease systems. Engineered and chimeric nucleases disclosed herein include nucleic acid guided nuclease. Additionally disclosed herein are methods of generating engineered nucleases and methods of using the same.
    Type: Application
    Filed: September 13, 2024
    Publication date: January 2, 2025
    Inventors: Brian C. Thomas, Alan Brooks, Christopher Brown, Cristina Noel Butterfield, Daniela S.A. Goltsman, Jyun-Liang Lin, Isabel Nocedal, Morayma Temoche-Diaz
  • Class II, type V CRISPR systems
    Patent number: 12123014
    Abstract: Described herein are methods, compositions, and systems derived from uncultivated microorganisms useful for gene editing.
    Type: Grant
    Filed: April 18, 2023
    Date of Patent: October 22, 2024
    Assignee: Metagenomi, Inc.
    Inventors: Brian Thomas, Christopher Brown, Audra Devoto, Cristina Butterfield, Lisa Alexander, Daniela S. A. Goltsman, Justine Albers, Alan Brooks, Greg Cost, Morayma Temoche-Diaz, Cindy Castelle, Rebecca Lamothe
  • BASE EDITING ENZYMES
    Publication number: 20240309404
    Abstract: The present disclosure provides for endonuclease enzymes having distinguishing domain features, as well as methods of using such enzymes or variants thereof.
    Type: Application
    Filed: May 2, 2024
    Publication date: September 19, 2024
    Inventors: Brian C. THOMAS, Jyun-Liang LIN, Alan BROOKS, Cristina BUTTERFIELD, Christopher BROWN, Cindy CASTELLE, Morayma TEMOCHE-DIAZ, Benjamin FREEMAN, Christine ROMANO, Rebecca LAMOTHE
  • CLASS II, TYPE V CRISPR SYSTEMS
    Publication number: 20240093239
    Abstract: Described herein are methods, compositions, and systems derived from uncultivated microorganisms useful for gene editing.
    Type: Application
    Filed: April 18, 2023
    Publication date: March 21, 2024
    Inventors: Brian THOMAS, Christopher BROWN, Audra DEVOTO, Cristina BUTTERFIELD, Lisa ALEXANDER, Daniela S.A. GOLTSMAN, Justine ALBERS, Alan BROOKS, Greg COST, Morayma TEMOCHE-DIAZ, Cindy CASTELLE, Rebecca LAMOTHE
  • ENGINEERED AND CHIMERIC NUCLEASES
    Publication number: 20230416710
    Abstract: Disclosed herein are engineered nucleases and nuclease systems, including chimeric nucleases and chimeric nuclease systems. Engineered and chimeric nucleases disclosed herein include nucleic acid guided nuclease. Additionally disclosed herein are methods of generating engineered nucleases and methods of using the same.
    Type: Application
    Filed: November 17, 2022
    Publication date: December 28, 2023
    Inventors: Brian C. THOMAS, Christopher BROWN, Cristina BUTTERFIELD, Jyun-Liang LIN, Alan BROOKS, Morayma M. TEMOCHE-DIAZ, Greg COST, Rebecca LAMOTHE
  • BASE EDITING ENZYMES
    Publication number: 20230374482
    Abstract: The present disclosure provides for endonuclease enzymes having distinguishing domain features, as well as methods of using such enzymes or variants thereof.
    Type: Application
    Filed: May 31, 2023
    Publication date: November 23, 2023
    Inventors: Brian C. THOMAS, Alan BROOKS, Cristina BUTTERFIELD, Christopher BROWN, Cindy CASTELLE, Jyun-Liang LIN
  • BASE EDITING ENZYMES
    Publication number: 20230348877
    Abstract: The present disclosure provides for endonuclease enzymes having distinguishing domain features, as well as methods of using such enzymes or variants thereof.
    Type: Application
    Filed: March 8, 2023
    Publication date: November 2, 2023
    Inventors: Jyun-Liang LIN, Alan BROOKS, Cristina BUTTERFIELD, Christopher BROWN, Cindy CASTELLE, Brian C. Thomas
  • BASE EDITING ENZYMES
    Publication number: 20230348876
    Abstract: The present disclosure provides for endonuclease enzymes having distinguishing domain features, as well as methods of using such enzymes or variants thereof.
    Type: Application
    Filed: March 7, 2023
    Publication date: November 2, 2023
    Inventors: Jyun-Liang LIN, Alan BROOKS, Cristina BUTTERFIELD, Christopher BROWN, Cindy CASTELLE, Brian C. Thomas
  • Class II, type V CRISPR systems
    Patent number: 11713471
    Abstract: Described herein are methods, compositions, and systems derived from uncultivated microorganisms useful for gene editing.
    Type: Grant
    Filed: March 28, 2022
    Date of Patent: August 1, 2023
    Assignee: METAGENOMI, INC.
    Inventors: Brian Thomas, Christopher Brown, Audra Devoto, Cristina Butterfield, Lisa Alexander, Daniela S. A. Goltsman, Justine Albers, Alan Brooks, Greg Cost, Morayma Temoche-Diaz, Cindy Castelle, Rebecca Lamothe
  • CLASS II, TYPE V CRISPR SYSTEMS
    Publication number: 20230227857
    Abstract: Described herein are methods, compositions, and systems derived from uncultivated microorganisms useful for gene editing.
    Type: Application
    Filed: September 6, 2022
    Publication date: July 20, 2023
    Inventors: Brian THOMAS, Christopher BROWN, Audra DEVOTO, Cristina BUTTERFIELD, Lisa ALEXANDER, Daniela S.A. GOLTSMAN, Justine B. ALBERS, Alan BROOKS, Greg COST, Morayma TEMOCHE-DIAZ, Cindy CASTELLE, Rebecca LAMOTHE
  • BASE EDITING ENZYMES
    Publication number: 20220364067
    Abstract: The present disclosure provides for endonuclease enzymes having distinguishing domain features, as well as methods of using such enzymes or variants thereof.
    Type: Application
    Filed: June 15, 2022
    Publication date: November 17, 2022
    Inventors: Jyun-Liang LIN, Alan BROOKS, Cristina BUTTERFIELD, Christopher BROWN, Cindy CASTELLE
  • CLASS II, TYPE V CRISPR SYSTEMS
    Publication number: 20220290187
    Abstract: Described herein are methods, compositions, and systems derived from uncultivated microorganisms useful for gene editing.
    Type: Application
    Filed: March 28, 2022
    Publication date: September 15, 2022
    Inventors: Brian C. THOMAS, Christopher BROWN, Audra DEVOTO, Cristina BUTTERFIELD, Lisa ALEXANDER, Daniela S.A. GOLTSMAN, Justine B. ALBERS, Alan BROOKS, Greg COST, Morayma TEMOCHE-DIAZ, Cindy CASTELLE, Rebecca LAMOTHE