Patents by Inventor Alan Brooks

Alan Brooks has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Base editing enzymes
    Patent number: 12286654
    Abstract: The present disclosure provides for endonuclease enzymes having distinguishing domain features, as well as methods of using such enzymes or variants thereof.
    Type: Grant
    Filed: June 15, 2022
    Date of Patent: April 29, 2025
    Assignee: Metagenomi, Inc.
    Inventors: Jyun-Liang Lin, Alan Brooks, Cristina Butterfield, Christopher Brown, Cindy Castelle, Brian C. Thomas
  • Method for the manufacture of hydraulic binders from water treatment residuals
    Patent number: 12275673
    Abstract: A method for the manufacture of a high alumina hydraulic binder comprising hydrating a source of aluminium ions with a source of calcium ions in the presence of water to form mineral hydrates and subsequently heating said mineral hydrates to form said high alumina hydraulic binder.
    Type: Grant
    Filed: June 12, 2020
    Date of Patent: April 15, 2025
    Assignee: ARDEX Group GmbH
    Inventors: Stephen Alan Brooks, Mark Russell
  • CLASS II, TYPE V CRISPR SYSTEMS
    Publication number: 20250059568
    Abstract: Described herein are methods, compositions, and systems derived from uncultivated microorganisms useful for gene editing.
    Type: Application
    Filed: August 27, 2024
    Publication date: February 20, 2025
    Inventors: Brian THOMAS, Christopher BROWN, Audra DEVOTO, Cristina BUTTERFIELD, Lisa ALEXANDER, Daniela S.A. GOLTSMAN, Justine ALBERS, Alan BROOKS, Greg COST, Morayma TEMOCHE-DIAZ, Cindy CASTELLE, Rebecca LAMOTHE
  • ENGINEERED AND CHIMERIC NUCLEASES
    Publication number: 20250002886
    Abstract: Disclosed herein are engineered nucleases and nuclease systems, including chimeric nucleases and chimeric nuclease systems. Engineered and chimeric nucleases disclosed herein include nucleic acid guided nuclease. Additionally disclosed herein are methods of generating engineered nucleases and methods of using the same.
    Type: Application
    Filed: September 13, 2024
    Publication date: January 2, 2025
    Inventors: Brian C. Thomas, Alan Brooks, Christopher Brown, Cristina Noel Butterfield, Daniela S.A. Goltsman, Jyun-Liang Lin, Isabel Nocedal, Morayma Temoche-Diaz
  • Class II, type V CRISPR systems
    Patent number: 12123014
    Abstract: Described herein are methods, compositions, and systems derived from uncultivated microorganisms useful for gene editing.
    Type: Grant
    Filed: April 18, 2023
    Date of Patent: October 22, 2024
    Assignee: Metagenomi, Inc.
    Inventors: Brian Thomas, Christopher Brown, Audra Devoto, Cristina Butterfield, Lisa Alexander, Daniela S. A. Goltsman, Justine Albers, Alan Brooks, Greg Cost, Morayma Temoche-Diaz, Cindy Castelle, Rebecca Lamothe
  • Process for producing a binder
    Patent number: 12122725
    Abstract: The invention relates to a method of producing a binder comprising the steps of preparing (20) a residual material comprising amorphous alumina-rich and/or aluminium hydroxide-rich constituents, heating (30) the residual material to produce a fired material, the heating (30) of the residual material being at a temperature of >800° C.
    Type: Grant
    Filed: December 11, 2020
    Date of Patent: October 22, 2024
    Assignee: ARDEX Group GmbH
    Inventors: Stephen Alan Brooks, Rüdiger Oberste-Padtberg, Jörg Sieksmeier, Hubert Motzet, Michael Pomberg
  • BASE EDITING ENZYMES
    Publication number: 20240309404
    Abstract: The present disclosure provides for endonuclease enzymes having distinguishing domain features, as well as methods of using such enzymes or variants thereof.
    Type: Application
    Filed: May 2, 2024
    Publication date: September 19, 2024
    Inventors: Brian C. THOMAS, Jyun-Liang LIN, Alan BROOKS, Cristina BUTTERFIELD, Christopher BROWN, Cindy CASTELLE, Morayma TEMOCHE-DIAZ, Benjamin FREEMAN, Christine ROMANO, Rebecca LAMOTHE
  • CLASS II, TYPE V CRISPR SYSTEMS
    Publication number: 20240093239
    Abstract: Described herein are methods, compositions, and systems derived from uncultivated microorganisms useful for gene editing.
    Type: Application
    Filed: April 18, 2023
    Publication date: March 21, 2024
    Inventors: Brian THOMAS, Christopher BROWN, Audra DEVOTO, Cristina BUTTERFIELD, Lisa ALEXANDER, Daniela S.A. GOLTSMAN, Justine ALBERS, Alan BROOKS, Greg COST, Morayma TEMOCHE-DIAZ, Cindy CASTELLE, Rebecca LAMOTHE
  • ENGINEERED AND CHIMERIC NUCLEASES
    Publication number: 20230416710
    Abstract: Disclosed herein are engineered nucleases and nuclease systems, including chimeric nucleases and chimeric nuclease systems. Engineered and chimeric nucleases disclosed herein include nucleic acid guided nuclease. Additionally disclosed herein are methods of generating engineered nucleases and methods of using the same.
    Type: Application
    Filed: November 17, 2022
    Publication date: December 28, 2023
    Inventors: Brian C. THOMAS, Christopher BROWN, Cristina BUTTERFIELD, Jyun-Liang LIN, Alan BROOKS, Morayma M. TEMOCHE-DIAZ, Greg COST, Rebecca LAMOTHE
  • BASE EDITING ENZYMES
    Publication number: 20230374482
    Abstract: The present disclosure provides for endonuclease enzymes having distinguishing domain features, as well as methods of using such enzymes or variants thereof.
    Type: Application
    Filed: May 31, 2023
    Publication date: November 23, 2023
    Inventors: Brian C. THOMAS, Alan BROOKS, Cristina BUTTERFIELD, Christopher BROWN, Cindy CASTELLE, Jyun-Liang LIN
  • BASE EDITING ENZYMES
    Publication number: 20230348876
    Abstract: The present disclosure provides for endonuclease enzymes having distinguishing domain features, as well as methods of using such enzymes or variants thereof.
    Type: Application
    Filed: March 7, 2023
    Publication date: November 2, 2023
    Inventors: Jyun-Liang LIN, Alan BROOKS, Cristina BUTTERFIELD, Christopher BROWN, Cindy CASTELLE, Brian C. Thomas
  • BASE EDITING ENZYMES
    Publication number: 20230348877
    Abstract: The present disclosure provides for endonuclease enzymes having distinguishing domain features, as well as methods of using such enzymes or variants thereof.
    Type: Application
    Filed: March 8, 2023
    Publication date: November 2, 2023
    Inventors: Jyun-Liang LIN, Alan BROOKS, Cristina BUTTERFIELD, Christopher BROWN, Cindy CASTELLE, Brian C. Thomas
  • Class II, type V CRISPR systems
    Patent number: 11713471
    Abstract: Described herein are methods, compositions, and systems derived from uncultivated microorganisms useful for gene editing.
    Type: Grant
    Filed: March 28, 2022
    Date of Patent: August 1, 2023
    Assignee: METAGENOMI, INC.
    Inventors: Brian Thomas, Christopher Brown, Audra Devoto, Cristina Butterfield, Lisa Alexander, Daniela S. A. Goltsman, Justine Albers, Alan Brooks, Greg Cost, Morayma Temoche-Diaz, Cindy Castelle, Rebecca Lamothe
  • CLASS II, TYPE V CRISPR SYSTEMS
    Publication number: 20230227857
    Abstract: Described herein are methods, compositions, and systems derived from uncultivated microorganisms useful for gene editing.
    Type: Application
    Filed: September 6, 2022
    Publication date: July 20, 2023
    Inventors: Brian THOMAS, Christopher BROWN, Audra DEVOTO, Cristina BUTTERFIELD, Lisa ALEXANDER, Daniela S.A. GOLTSMAN, Justine B. ALBERS, Alan BROOKS, Greg COST, Morayma TEMOCHE-DIAZ, Cindy CASTELLE, Rebecca LAMOTHE
  • BASE EDITING ENZYMES
    Publication number: 20220364067
    Abstract: The present disclosure provides for endonuclease enzymes having distinguishing domain features, as well as methods of using such enzymes or variants thereof.
    Type: Application
    Filed: June 15, 2022
    Publication date: November 17, 2022
    Inventors: Jyun-Liang LIN, Alan BROOKS, Cristina BUTTERFIELD, Christopher BROWN, Cindy CASTELLE
  • Process for Producing a Binder
    Publication number: 20220298068
    Abstract: The invention relates to a method of producing a binder comprising the steps of preparing (20) a residual material comprising amorphous alumina-rich and/or aluminium hydroxide-rich constituents, heating (30) the residual material to produce a fired material, the heating (30) of the residual material being at a temperature of >800° C.
    Type: Application
    Filed: December 11, 2020
    Publication date: September 22, 2022
    Inventors: Stephen Alan Brooks, Rüdiger Oberste-Padtberg, Jörg Sieksmeier, Hubert Motzet, Michael Pomberg
  • CLASS II, TYPE V CRISPR SYSTEMS
    Publication number: 20220290187
    Abstract: Described herein are methods, compositions, and systems derived from uncultivated microorganisms useful for gene editing.
    Type: Application
    Filed: March 28, 2022
    Publication date: September 15, 2022
    Inventors: Brian C. THOMAS, Christopher BROWN, Audra DEVOTO, Cristina BUTTERFIELD, Lisa ALEXANDER, Daniela S.A. GOLTSMAN, Justine B. ALBERS, Alan BROOKS, Greg COST, Morayma TEMOCHE-DIAZ, Cindy CASTELLE, Rebecca LAMOTHE
  • Use of a Hydraulic Binder Containing Calcium Aluminate for the Production of a Construction Material
    Publication number: 20220242788
    Abstract: The invention relates to the use of a hydraulic binder containing calcium aluminate, obtainable by a method in which a) prepared amorphous residual material rich in aluminium oxide and/or aluminium hydroxide is heated after the addition of a b) calcium ion-containing binder component and c) water, for the production of a constructing material.
    Type: Application
    Filed: June 12, 2020
    Publication date: August 4, 2022
    Inventors: Stephen Alan Brooks, Rüdiger Oberste-Padtberg, Jörg Sieksmeier, Hubert Motzet, Michael Pomberg
  • A Method for the Manufacture of Hydraulic Binders from Water Treatment Residuals
    Publication number: 20220227666
    Abstract: A method for the manufacture of a high alumina hydraulic binder comprising hydrating a source of aluminium ions with a source of calcium ions in the presence of water to form mineral hydrates and subsequently heating said mineral hydrates to form said high alumina hydraulic binder.
    Type: Application
    Filed: June 12, 2020
    Publication date: July 21, 2022
    Inventors: Stephen Alan Brooks, Mark Russell
  • RED BLOOD CELL TARGETED FACTOR VIII AND METHOD OF USING THE SAME
    Publication number: 20220089685
    Abstract: Targeted Factor VIII molecules comprising a Factor VIII linked with at least one domain that specifically binds to a membrane protein on a red blood cell is provided. The disclosed targeted coagulation factors prolong their duration of action and thus, are an improvement for the treatment of hematological diseases such as hemophilia A.
    Type: Application
    Filed: June 18, 2021
    Publication date: March 24, 2022
    Inventors: Alan Brooks, Richard Feldman, Jian-Ming GU, Shaun Lippow, Shujun Yuan, Peter Bringmann