Patents by Inventor Alan C. Barnes

Alan C. Barnes has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 4644002
    Abstract: Novel compounds of the formula ##STR1## wherein A is selected from the group consisting of nitrogen and .dbd.CH--, G is ##STR2## Z is selected from the group consisting of hydrogen and alkyl of 1 to 5 carbon atoms or taken with Y forms a carbon-carbon bond, Z' is selected from the group consisting of hydrogen and halogen, Y is hydrogen, or taken with Z is a carbon-carbon bond or taken with X is .dbd.O and X is hydrogen or taken with Y is .dbd.O, R is selected from the group consisting of hydroxymethyl, formyl, tetrazol-5-yl, N-(tetrazol-5-yl) carbamoyl, aminomethyl and carbamoyl, R.sub.1 is selected from the group consisting of hydrogen, halogen and alkoxy of 1 to 5 carbon atoms and its non-toxic, pharmaceutically acceptable acid addition salts having antiallergic activity and their preparation.
    Type: Grant
    Filed: October 23, 1985
    Date of Patent: February 17, 1987
    Assignee: Roussel Uclaf
    Inventors: Alan C. Barnes, David A. Rowlands
  • Patent number: 4474784
    Abstract: Novel compounds of the formula ##STR1## wherein A is selected from the group consisting of nitrogen and .dbd.CH--, G is selected from the group consisting of --0--, ##STR2## Z is selected from the group consisting of hydrogen and alkyl of 1 to 5 carbon atoms or taken with Y forms a carbon-nitrogen or carbon-carbon bond, Z' is selected from the group consisting of hydrogen and halogen, Y is hydrogen, or taken with Z is a carbon-nitrogen or carbon-carbon bond or taken with X is .dbd.0 and X is hydrogen or taken with Y is .dbd.0, R is selected from the group consisting of hydroxymethyl, formyl, tetrazol-5-yl, N-(tetrazol-5-yl) carbamoyl, aminomethyl and carbamoyl, R.sub.1 is selected from the group consisting of hydrogen, halogen and alkoxy of 1 to 5 carbon atoms and its non-toxic, pharmaceutically acceptable acid addition salts having anti-allergic activity and their preparation.
    Type: Grant
    Filed: March 1, 1982
    Date of Patent: October 2, 1984
    Assignee: Roussel Uclaf
    Inventors: Alan C. Barnes, David A. Rowlands
  • Patent number: 4464373
    Abstract: Novel imidazoquinoxalines of the formula ##STR1## wherein R.sub.1 is selected from the group consisting of hydroxy, alkoxy of 1 to 5 carbon atoms and cyclohexylcarbonyloxymethoxy, R.sub.2 is selected from the group consisting of hydrogen, alkyl of 1 to 8 carbon atoms, alkoxycarbonylvinyl of 4 to 7 carbon atoms, --COR, --CONH(CH.sub.2).sub.n --X and --A--(CH.sub.2).sub.m --Y, R is selected from the group consisting of hydrogen, alkyl of 1 to 8 carbon atoms, cycloalkyl of 3 to 10 carbon atoms, alkenyl of 2 to 4 carbon atoms, alkoxy of 1 to 5 carbon atoms, alkoxycarbonyl of 2 to 5 carbon atoms, amino, --CF.sub.3, --CHCl.sub.2 --, phenyl, aralkyl of 7 to 10 carbon atoms, aralkoxy of 7 to 10 carbon atoms, n is 0 and X is phenyl or n is an integer from 1 to 5 and X is selected from the group consisting of ##STR2## R.sub.3 and R.sub.
    Type: Grant
    Filed: April 22, 1983
    Date of Patent: August 7, 1984
    Assignee: Roussel Uclaf
    Inventors: Alan C. Barnes, David P. Kay, Peter D. Kennewell, Frederick L. Parker, David A. Rowlands
  • Patent number: 4387098
    Abstract: Novel imidazo[1,2-a]quinolines of the formula ##STR1## wherein R is selected from the group consisting of alkyl of 1 to 8 carbon atoms, thienyl, pyridyl and phenyl optionally substituted with at least one member of the group consisting of halogen, alkyl of 1 to 5 carbon atoms and alkoxy of 1 to 5 carbon atoms, R.sub.1 and R.sub.2 are individually selected from the group consisting of hydrogen, halogen, alkyl and alkoxy of 1 to 8 carbon atoms,s cyclohexyl, --NO.sub.2 and phenoxy, R.sub.3 is selected from the group consisting of alkoxy and alkylthio of 1 to 8 carbon atoms and their non-toxic, pharmaceutically acceptable acid addition salts having a remarkable anxiolytic activity and a hypnotic activity and their preparation.
    Type: Grant
    Filed: March 25, 1982
    Date of Patent: June 7, 1983
    Assignee: Roussel Uclaf
    Inventors: Alan C. Barnes, Peter A. Robson
  • Patent number: 4333934
    Abstract: Novel compounds of the formula ##STR1## wherein A is selected from the group consisting of nitrogen and .dbd.CH--, G is selected from the group consisting of ##STR2## Z is selected from the group consisting of hydrogen and alkyl of 1 to 5 carbon atoms or taken with Y forms a carbon-nitrogen or carbon-carbon bond, Z' is selected from the group consisting of hydrogen and halogen, Y is hydrogen, or taken with Z is a carbon-nitrogen or carbon-carbon bond or taken with X is .dbd.O and X is hydrogen or taken with Y is .dbd.O, R is selected from the group consisting of hydroxymethyl, formyl, tetrazol-5-yl, N-(tetrazol-5-yl) carbamoyl, aminomethyl and carbamoyl, R.sub.1 is selected from the group consisting of hydrogen, halogen and alkoxy of 1 to 5 carbon atoms and its non-toxic, pharmaceutically acceptable acid addition salts having antiallergic activity and their preparation.
    Type: Grant
    Filed: February 4, 1980
    Date of Patent: June 8, 1982
    Assignee: Roussel Uclaf
    Inventors: Alan C. Barnes, David A. Rowlands
  • Patent number: 4291033
    Abstract: Novel oxoimidazoquinoxalines of the formula ##STR1## wherein R.sub.1 and R.sub.2 are individually selected from the group consisting of hydrogen, chlorine and bromine, X is selected from the group consisting of hydrogen, alkyl of 1 to 5 carbon atoms, cycloalkyl of 3 to 5 carbon atoms and cycloalkyl-alkyl of 4 to 6 carbon atoms, R.sub.3 is selected from the group consisting of hydrogen alkyl of 1 to 5 carbon atoms, alkali metal, alkaline earth metal, aluminum, --NH.sub.4, organic amine and ##STR2## R.sub.4 and R.sub.5 are individually alkyl of 1 to 5 carbon atoms or taken together with the nitrogen atom form a saturated heterocycle of 4 to 6 carbon atoms optionally containing an oxygen atom or second nitrogen atom and n is a number from 1 to 5 and their non-toxic, pharmaceutically acceptable acid addition salts having antiallergic activity and their preparation.
    Type: Grant
    Filed: February 4, 1980
    Date of Patent: September 22, 1981
    Assignee: Roussel Uclaf
    Inventors: Alan C. Barnes, David P. Kay
  • Patent number: 4254123
    Abstract: Novel imidazoquinoxalines of the formula ##STR1## wherein R is selected from the group consisting of hydrogen, alkyl of 1 to 5 carbon atoms, --NH.sub.4, alkali metal, alkaline earth metal, magnesium, aluminum and non-toxic, pharmaceutically acceptable amines, X is selected from the group consisting of hydrogen, alkoxy of 1 to 5 carbon atoms and carbamoyl and Y and Z are individually selected from the group consisting of hydrogen and halogen and their non-toxic, pharmaceutically acceptable acid addition salts having anti-allergic activity and their preparation.
    Type: Grant
    Filed: July 30, 1979
    Date of Patent: March 3, 1981
    Assignee: Roussel Uclaf
    Inventors: Peter J. Ramm, Alan C. Barnes
  • Patent number: 4242267
    Abstract: A novel process for the preparation of xanthane-2-carboxylic acids of the formula ##STR1## wherein R is selected from the group consisting of hydrogen and alkyl of 1 to 9 carbon atoms and R.sub.1 is alkyl of 1 to 5 carbon atoms which possess an antiallergic activity and are particularly useful for treating asthma and asthmatic form bronchitisis of allergic origin.
    Type: Grant
    Filed: February 4, 1980
    Date of Patent: December 30, 1980
    Assignee: Roussel Uclaf
    Inventors: Alan C. Barnes, Peter D. Kennewell