Patents by Inventor Alan C. Gibbs

Alan C. Gibbs has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • HETEROATOM SUBSTITUTED CYCLIC AND ALKYL AMINES AS ACTIVATORS OF SEROTONIN RECEPTORS
    Publication number: 20240116896
    Abstract: The present disclosure provides N,N-dimethyltryptamine (N,N-DMT) derivatives of the present disclosure provides compounds of formula (I), (I-A), (I-B), (I-C), (II), (II-A), (III), and (IV), or pharmaceutically acceptable salts or deuterated forms thereof. Also provided herein are methods of using the N,N-DMT derivatives, e.g., in the treatment of mental health diseases and/or disorders.
    Type: Application
    Filed: September 6, 2023
    Publication date: April 11, 2024
    Inventors: Tanweer A. KHAN, Alan C. GIBBS, Glenn SHORT, Robert B. PERNI
  • Prodrugs of MDMA, MDA, and derivatives thereof
    Patent number: 11845736
    Abstract: The present disclosure provides prodrug compounds of MDMA, MDA, and derivatives thereof having an improved pharmacokinetic profile suitable for the treatment of various neurological diseases.
    Type: Grant
    Filed: October 3, 2022
    Date of Patent: December 19, 2023
    Assignee: EmpathBio, Inc.
    Inventors: Srinivas Rao, Glenn Short, Robert B. Perni, Tanweer A. Khan, Alan C. Gibbs
  • PRODRUGS OF MDMA, MDA, AND DERIVATIVES THEREOF
    Publication number: 20230227420
    Abstract: The present disclosure provides prodrug compounds of MDMA, MDA, and derivatives thereof having an improved pharmacokinetic profile suitable for the treatment of various neurological diseases.
    Type: Application
    Filed: October 3, 2022
    Publication date: July 20, 2023
    Inventors: Srinivas RAO, Glenn SHORT, Robert B. PERNI, Tanweer A. KHAN, Alan C. GIBBS
  • Indazole compounds useful as ketohexokinase inhibitors
    Patent number: 9771375
    Abstract: The present invention is directed to substituted indazole compounds, pharmaceutical compositions of these compounds and methods of use thereof. The compounds of the present invention are ketohexokinase (KHK) inhibitors, useful for treating or ameliorating a KHK mediated metabolic disorders and/or diseases such as obesity, Type II diabetes mellitus and Metabolic Syndrome X. In some embodiments, the substituted indazole compounds are of formula I, wherein R1-R3, Q, X, Y, Z, a, and b are defined herein.
    Type: Grant
    Filed: July 23, 2014
    Date of Patent: September 26, 2017
    Assignee: Janssen Pharmaceutica NV
    Inventors: Xuqing Zhang, Marta C Abad, Alan C. Gibbs, Gee-Hong Kuo, Fengbin Song, Zhihua Sui, Lawrence C. Kuo
  • INDAZOLE COMPOUNDS USEFUL AS KETOHEXOKINASE INHIBITORS
    Publication number: 20140336170
    Abstract: The present invention is directed to substituted indazole compounds, pharmaceutical compositions of these compounds and methods of use thereof. The compounds of the present invention are ketohexokinase (KHK) inhibitors, useful for treating or ameliorating a KHK mediated metabolic disorders and/or diseases such as obesity, Type II diabetes mellitus and Metabolic Syndrome X.
    Type: Application
    Filed: July 23, 2014
    Publication date: November 13, 2014
    Applicant: JANSSEN PHARMACEUTICA NV
    Inventors: Xuqing Zhang, Marta C. Abad, Alan C. Gibbs, Gee-Hong Kuo, Fengbin Song, Zhihua Sui
  • Indazole compounds useful as ketohexokinase inhibitors
    Patent number: 8822447
    Abstract: The present invention is directed to substituted indazole compounds of formula (I) pharmaceutical compositions of these compounds and methods of use thereof. The compounds of the present invention are ketohexokinase (KHK) inhibitors, useful for treating or ameliorating a KHK mediated metabolic disorders and/or diseases such as obesity, Type II diabetes mellitus and Metabolic Syndrome X.
    Type: Grant
    Filed: April 21, 2011
    Date of Patent: September 2, 2014
    Assignee: Janssen Pharmaceutica NV
    Inventors: Xuqing Zhang, Marta C. Abad, Alan C. Gibbs, Gee-Hong Kuo, Lawrence C. Kuo, Fengbin Song, Zhihua Sui
  • INDAZOLE COMPOUNDS USEFUL AS KETOHEXOKINASE INHIBITORS
    Publication number: 20110263559
    Abstract: The present invention is directed to substituted indazole compounds, pharmaceutical compositions of these compounds and methods of use thereof. The compounds of the present invention are ketohexokinase (KHK) inhibitors, useful for treating or ameliorating a KHK mediated metabolic disorders and/or diseases such as obesity, Type II diabetes mellitus and Metabolic Syndrome X.
    Type: Application
    Filed: April 21, 2011
    Publication date: October 27, 2011
    Inventors: Xuqing ZHANG, Marta G. ABAD, Alan C. GIBBS, Gee-Hong KUO, Lawrence C. KUO, Fengbin SONG, Zhihua SUI
  • CRYSTAL STRUCTURE OF THE CARBOXYL TRANSFERASE DOMAIN OF HUMAN ACETYL-COA CARBOXYLASE 2 PROTEIN (ACC2 CT) AND USES THEREOF
    Publication number: 20090155815
    Abstract: A crystallized human ACC2 CT protein as well as a description of the X-ray diffraction pattern of the crystal are disclosed. The diffraction pattern allows the three dimensional structure of human ACC2 CT to be determined at atomic resolution so that ligand binding sites on human ACC2 CT can be identified and the interactions of ligands with human ACC2 CT amino acid residues can be modeled. Models prepared using such maps permit the design of ligands which can function as active agents which include, but are not limited to, those that function as inhibitors of human ACC2 and human ACC1 proteins.
    Type: Application
    Filed: October 24, 2008
    Publication date: June 18, 2009
    Inventors: Bruce L. Grasberger, Cynthia Milligan, John C. Spurlino, Ruth A. Steele, Kenneth R. Singleton, Alan C. Gibbs, Francis A. Lewandowski