Patents by Inventor Alan C. Hayman

Alan C. Hayman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Formulation and use of carotenoids in treatment of cancer
    Patent number: 6200597
    Abstract: A reduced-toxicity formulation of carotenoids is disclosed which is stable in an aqueous environment. The formulation includes a carotenoid, lipid arrier particles (such as liposomes), and an intercalation promoter agent (such as a triglyceride), which causes the carotenoid to be substantially uniformly distributed with the lipid in the lipid carrier particles. The molar ratio of carotenoid to lipid is greater than about 1:10. Also disclosed is a method of inhibiting the growth of cancer cells, which comprises administering to a living subject a therapeutically effective amount of a composition as described above.
    Type: Grant
    Filed: June 10, 1998
    Date of Patent: March 13, 2001
    Assignees: Board of Regents, The University of Texas System, Aronex Pharmaceuticals, Inc.
    Inventors: Kapil Mehta, Roman Perez-Soler, Gabriel Lopez-Berestein, Robert Lenk, Alan C. Hayman
  • Formulation and use of carotenoids in treatment of cancer
    Patent number: 5811119
    Abstract: A reduced-toxicity formulation of carotenoids is disclosed which is stable in an aqueous environment. The formulation includes a carotenoid, lipid carrier particles (such as liposomes), and an intercalation promoter agent (such as a triglyceride), which causes the carotenoid to be substantially uniformly distributed with the lipid in the lipid carrier particles. The molar ratio of carotenoid to lipid is greater than about 1:10. Also disclosed is a method of inhibiting the growth of cancer cells, which comprises administering to a living subject a therapeutically effective amount of a composition as described above.
    Type: Grant
    Filed: October 22, 1996
    Date of Patent: September 22, 1998
    Assignees: Board of Regents, the University of Texas, Aronex Pharmaceuticals, Inc.
    Inventors: Kapil Mehta, Roman Perez-Soler, Gabriel Lopez-Berestein, Robert P. Lenk, Alan C. Hayman, deceased
  • Purification of active and inactive/latent forms of plasminogen activator inhibitor-1
    Patent number: 5260419
    Abstract: A method of separating active and inactive/latent forms of PAI-1 is disclosed comprising loading a sample containing a mixture of active and inactive/latent forms of PAI-1 to either an anion or cation exchange resin of 10-50 micron particle size and eluting active and inactive/latent forms of PAI-1 from the resin into separate fractions. Also disclosed is a method of extracting soluble E. coli-expressed recombinant PAI-1 from the lysed E. coli host cells in a buffered solution, wherein the ionic strength of the buffered solution is 8-25 millisiemens.
    Type: Grant
    Filed: March 20, 1991
    Date of Patent: November 9, 1993
    Assignee: The DuPont Merck Pharmaceutical Company
    Inventors: Alan C. Hayman, Jodie L. Duke, Jr.