Abstract: Cyclic aspiration system producing a cyclic aspiration pressure waveform of intermittent cyclic intervals of vacuum pressure below atmospheric pressure and a positive pressure higher than the vacuum pressure. The system including an aspiration catheter, a vacuum pump, and connected in fluid communication therebetween a positive pressure pulse generator mechanism including at least one displaceable member displaceable within a housing, wherein the at least one displaceable member controls passage therethrough the housing of the vacuum pressure and produces the positive pressure pulse by compressing collectable fluid therein. The system further including at least one actuator arranged externally of the housing displacing the at least one displaceable member within the housing.

Abstract: Unidirectional continuous loop hybrid cyclic aspiration system including a vacuum pump and associated vacuum collection vessel connected to a liquid reservoir open to atmosphere; inlet tubing having defined therein a vacuum pressure lumen and a positive pressure lumen; an aspiration catheter in fluid communication to the inlet tubing; and a positive pressure pulse generator mechanism intermittently radially compressing the positive pressure lumen creating a positive pressure pulse; a vacuum pressure gating device controlling passage through the vacuum lumen; and a liquid replenishing gating device controlling passage of the liquid from the liquid reservoir open to the atmosphere replenishing the aspirated into the vacuum collection vessel.

Abstract: Delivery catheters for occluding aneurysms, the delivery catheter including a catheter tubing extending a length. In some configurations the catheter may include a reflux-occluder section having a third diameter greater than the first diameter and the second diameter. The reflux-occluder section is disposed along the length of the catheter tubing between the proximal portion and the distal portion. Certain implementations of the catheters may include an expansile section having a collapsed configuration with a first diameter and an expanded configuration with a second diameter, the second diameter sized to prevent reflux of glue proximal to the expansile section within a vessel. Configuration of the catheter may include a cyclic pump to create a fluid column proximate the distal end and positioned between the distal end and the glue to prevent reflux of the glue proximal to the distal end.

Abstract: Cyclic aspiration system producing a cyclic aspiration pressure waveform of intermittent cyclic intervals of vacuum pressure below atmospheric pressure and a positive pressure higher than the vacuum pressure. The system including an aspiration catheter, a vacuum pump, and connected in fluid communication therebetween a positive pressure pulse generator mechanism including at least one displaceable member displaceable within a housing, wherein the at least one displaceable member controls passage therethrough the housing of the vacuum pressure and produces the positive pressure pulse by compressing collectable fluid therein. The system further including at least one actuator arranged externally of the housing displacing the at least one displaceable member within the housing.

Abstract: Cyclic aspiration system producing a cyclic aspiration pressure waveform of intermittent cycles of vacuum pressure below atmospheric pressure and positive pressure higher than vacuum pressure. The system includes a dual pressure generator receptacle disposed proximally of and connected in fluid communication with an aspiration catheter. The dual pressure generator receptacle receiving a collectable fluid therein that is intermittently cyclically subjectable to application or withdraw of a compressible force via a linear displacement mechanism. Positive pressure is generated while the collectable fluid in the dual pressure generator receptacle is subject to the compressive force and vacuum pressure is generated when not subject to the compressive force. The cyclic aspiration pressure waveform is produced via the dual pressure generator receptacle without a separate vacuum pump.

Abstract: Cyclic aspiration system producing a cyclic aspiration pressure waveform of intermittent cyclic intervals of vacuum pressure below atmospheric pressure and positive pressure higher than vacuum pressure. The system including flexible inlet tubing connected in fluid communication between a vacuum pump and an aspiration catheter. A positive pressure pulse generator mechanism intermittently cyclically applies an external force compressing a section of the flexible inlet tubing reducing internal volume and displacing fluid collectable therein thereby generating a positive pressure pulse. Upon withdrawal of the external force applied, the flexible inlet tubing is configured to be forcibly restorable to a non-compressed state increasing the internal volume while reducing pressure therein until eventual regeneration of the vacuum pressure thereby minimizing recovery time and maximizing cycling frequency.

Abstract: Cyclic aspiration system producing an associated cyclic pressurized waveform of intermittent cyclic intervals of vacuum pressure below atmospheric pressure and a positive pressure higher than the vacuum pressure. The system including a vacuum pump generating vacuum pressure, a conduit connected in fluid communication to the vacuum pump, and an aspiration catheter connected in fluid communication to the conduit. Associated with the conduit is a positive pressure pulse generator mechanism that controls via a vacuum pressure gating device passage therethrough the conduit of the vacuum pressure generated by the vacuum pump and intermittently cyclically produces a positive pressure pulse.

Abstract: A system using bioelectric impedance to guide a flexible elongate transluminal device through an occlusion in a vessel. The device can be a guidewire or a device for performing an atherectomy, discectomy, ablation or similar technique. The device includes a first electrode disposed on a distal portion of the device. A second electrode is disposed in electric contact with the patient separate from the first electrode. An electric current is supplied between the first and second electrodes and a voltage drop is measured between the first and second electrodes. The voltage drop is converted to bioelectric impedance. Based on the impedance measurement, a clinician can determine if the device is approaching the vessel wall, permitting the clinician to redirect the device away from the vessel wall.

Abstract: A system using bioelectric impedance to guide a flexible elongate transluminal device through an occlusion in a vessel. The device can be a guidewire or a device for performing an atherectomy, discectomy, ablation or similar technique. The device includes a first electrode disposed on a distal portion of the device. A second electrode is disposed in electric contact with the patient separate from the first electrode. An electric current is supplied between the first and second electrodes and a voltage drop is measured between the first and second electrodes. The voltage drop is converted to bioelectric impedance. Based on the impedance measurement, a clinician can determine if the device is approaching the vessel wall, permitting the clinician to redirect the device away from the vessel wall.