Abstract: The present invention relates to oxaloacetate compounds that activate AMP-activated protein kinase (AMPK), including the preparation of the compounds, compositions containing the compounds, preserving said compounds and the use of the compounds in the prevention or treatment of disorders such as diabetes, metabolic syndrome, obesity, cardiovascular disease, Alzheimer's disease, and cancer.

Abstract: In a sealing arrangement between two discs of a gas turbine engine a split sealing arrangement comprising a pair of sealing formations each made up of a plurality of sealing segments is provided. Each of the segments has a root accommodated in serrations of the discs. The roots of the sealing segments are positively connected to roots of the rotor blades by dovetail or T-shaped tongues and grooves. The sealing segments are also provided with internal cooling passages.

Abstract: In a gas turbine engine including a turbine which has a closed cycle steam cooling system and an open cycle gas cooling system sealing arrangements are provided between adjacent pairs of turbine rotor stages. The sealing arrangement has axially extending passages to supply cooling gas from one of the turbine rotor stages to the cooling gas passages in the turbine rotor blades. Each sealing arrangement comprises a pair of sealing formations each made up of a plurality of sealing segments. Also the sealing arrangement has axially extending passages to supply steam from one of the turbine rotor stages to the steam cooling passages in the turbine rotor blades.