Abstract: A system for moving a portion of a patient's body including a housing having a first cavity extending along a longitudinal axis, a first distraction rod having a proximal end and a distal end, the first distraction rod and the housing being telescopically displaceable with respect to each other along the longitudinal axis, the first distraction rod having a cavity extending along the longitudinal axis, a second distraction rod having a proximal end and a distal end and configured to be telescopically displaceable from within the second cavity along the longitudinal axis, and a drive system configured to move the first distraction rod in relation to the housing and to move the second distraction rod in relation to the first distraction rod.

Abstract: Newly identified fungal sweet-taste modifying proteins, and the cDNA encoding said proteins are described. Specifically, Myd proteins active in sweet taste activation, and the cDNA encoding the same, are described, along with methods for isolating such cDNA and for isolating and expressing such proteins. Also disclosed is use of a sweetening composition which includes the proteins of the invention, and methods to provide improved flavor to a product for oral administration.

Abstract: A multi-die processor semiconductor package includes a first base integrated circuit (IC) die configured to provide, based at least in part on an indication of a configuration of a first plurality of compute dies 3D stacked on top of the first base IC die, a unique power domain to each of the first plurality of compute dies. In some embodiments, the semiconductor package also includes a second base IC die including a second plurality of compute dies 3D stacked on top of the second base IC die and an interconnect communicably coupling the first base IC die to the second base IC die.

Abstract: The present invention relates to the production of the receptor binding domain (RBD) of the Spike glycoprotein 1 of the SARS-CoV-2 in mammalian cell expression systems, and the successive method of purification thereof. A recombinant plasmid containing the coding sequence of said RBD is produced and transfected in said mammalian cells, for example, Expi293. A high level of the protein is secreted in the medium and subsequently purified using the N-terminal tag, that can be removed by a specific protease. The present invention also includes a recombinant expression vector carrying the RBD gene, the successive methods for protein purification, the strategy for establishing a stable cell line producing the RBD, methods of use of the recombinant protein in formulating a pharmaceutical composition, including but not limited to, vaccines for preventing SARS-CoV-2 induced diseases.

Abstract: The present invention relates to the production of the receptor binding domain (RBD) of the Spike glycoprotein 1 of the SARS-CoV-2 in mammalian cell expression systems, and the successive method of purification thereof. A recombinant plasmid containing the coding sequence of said RBD is produced and transfected in said mammalian cells, for example, Expi293. A high level of the protein is secreted in the medium and subsequently purified using the N-terminal tag, that can be removed by a specific protease. The present invention also includes a recombinant expression vector carrying the RBD gene, the successive methods for protein purification, the strategy for establishing a stable cell line producing the RBD, methods of use of the recombinant protein in formulating a pharmaceutical composition, including but not limited to, vaccines for preventing SARS-CoV-2 induced diseases.

Abstract: The present invention relates to the production of the receptor binding domain (RBD) of the Spike glycoprotein 1 of the SARS-CoV-2 in mammalian cell expression systems, and the successive method of purification thereof. A recombinant plasmid containing the coding sequence of said RBD is produced and transfected in said mammalian cells, for example, Expi293. A high level of the protein is secreted in the medium and subsequently purified using the N-terminal tag, that can be removed by a specific protease. The present invention also includes a recombinant expression vector carrying the RBD gene, the successive methods for protein purification, the strategy for establishing a stable cell line producing the RBD, methods of use of the recombinant protein in formulating a pharmaceutical composition, including but not limited to, vaccines for preventing SARS-CoV-2 induced diseases.

Abstract: Provided herein are computer-implemented methods of identifying programmed-death ligand 1 (PD-L1) expression status of a subject's sample comprising a cancer cell. In exemplary embodiments, the method comprises receiving an unlabeled expression data set for the subject's sample; aligning the unlabeled expression data set to labeled expression data according to a trained PD-L1 predictive model, wherein the trained PD-L1 predictive model has been trained with a plurality of labeled expression data sets, each labeled expression data set comprising expression data for a sample of a labeled cancer type and a labeled PD-L1 expression status; wherein aligning the unlabeled gene expression data set to labeled expression data according to the trained PD-L1 predictive model identifies PD-L1 expression status for the subject's sample. Further provided are related methods of preparing a clinical decision support information (CDSI) report and methods of determining treatment for a subject.

Abstract: The present disclosure relates in general to devices, systems and methods for wireless communication, and in particular to communication using a proximity integrated circuit card (PICC). Example embodiments include a circuit (100) for a PICC, the circuit comprising an input stage (101), a decoding module (106) and a bias adjustment module (117), the bias adjustment module (117) configured to receive an output code from the decoding module and provide a bias adjustment signal to the input stage (101), the bias adjustment module (117) configured to iteratively tune the bias adjustment signal based on a measurement of the output code, with successive steps tuning the bias adjustment signal by a smaller amount until the output code is within a decoding range.

Abstract: The present disclosure relates in general to devices, systems and methods for wireless communication, and in particular to communication using a proximity integrated circuit card (PICC). Example embodiments include a circuit (100) for a PICC, the circuit comprising an input stage (101), a decoding module (106) and a bias adjustment module (117), the bias adjustment module (117) configured to receive an output code from the decoding module and provide a bias adjustment signal to the input stage (101), the bias adjustment module (117) configured to iteratively tune the bias adjustment signal based on a measurement of the output code, with successive steps tuning the bias adjustment signal by a smaller amount until the output code is within a decoding range.

Abstract: A first home automation control device is configured to control a first electrical appliance and to communicate via a peer-to-peer network with a second home automation control device which is configured to control a second electrical appliance. When the first home automation control device discovers the presence of the second home automation control device, the first home automation control device negotiates with the second home automation control device to determine a goal. The first home automation control device and the second home automation control device then jointly execute a task to achieve the goal. The goal may be an energy savings goal.

Abstract: A solution for home automation management includes, at a network device configured to support multiple home automation technologies, receiving a message from a first home automation control device (HACD) managed by the network device, towards a second HACD managed by the network device. The network device translates the message to a form recognizable by the second HACD, and then sends the translated message towards the second HACD in accordance with home automation technology supported by the second HACD. According to one aspect, the solution may be extended to a network of multiple network devices configured to support multiple home automation technologies.

Abstract: A solution for home automation management includes, at a network device configured to support multiple home automation technologies, receiving a message from a first home automation control device (HACD) managed by the network device, towards a second HACD managed by the network device. The network device translates the message to a form recognizable by the second HACD, and then sends the translated message towards the second HACD in accordance with home automation technology supported by the second HACD. According to one aspect, the solution may be extended to a network of multiple network devices configured to support multiple home automation technologies.

Abstract: A first home automation control device is configured to control a first electrical appliance and to communicate via a peer-to-peer network with a second home automation control device which is configured to control a second electrical appliance. When the first home automation control device discovers the presence of the second home automation control device, the first home automation control device negotiates with the second home automation control device to determine a goal. The first home automation control device and the second home automation control device then jointly execute a task to achieve the goal. The goal may be an energy savings goal.

Abstract: A method in a mobile satellite positioning system receiver operating in cold-start mode, including searching for and detecting (310) a first satellite in a constellation of orbiting satellites, searching (320) for a second satellite based on detection probability information for non-detected satellites, the detection probability information obtained using information about one of satellites not detected or the first satellite detected. In one embodiment, the detection probability information is based on a measure of range between the non-detected satellites and the first satellite detected, and in another embodiment the detection probability information is based on a measure of angle between the non-detected satellites and the first satellite detected.

Abstract: A method in a mobile satellite positioning system receiver operating in cold-start mode, including searching for and detecting (310) a first satellite in a constellation of orbiting satellites, searching (320) for a second satellite based on detection probability information for non-detected satellites, the detection probability information obtained using information about one of satellites not detected or the first satellite detected. In one embodiment, the detection probability information is based on a measure of range between the non-detected satellites and the first satellite detected, and in another embodiment the detection probability information is based on a measure of angle between the non-detected satellites and the first satellite detected.