Abstract: An inhaler configured to dispense a dosage of one or more inhalable therapeutic agent to a user, the inhaler comprising a sensor to detect one or more biomarker present in gases expired by the user, said one or more biomarker suitably selected from: ketones; volatile organic compounds (VOC) including saturated and unsaturated hydrocarbons, sulphur-containing VOC and nitrogen-containing VOC; nitric oxide; dimethyl sulphide; ethanol; acetaldehyde; short chain alkanes (e.g. ethane and/or pentane); cyclic monoterpenes, e.g. limonene; and wherein said dosage of one or more inhalable therapeutic agent is dispensed into a flow passage defined within the inhaler, and the sensor is configured to detect the presence of said one or more biomarkers in a fluid flow within the flow passage.

Abstract: An inhaler configured to dispense a dosage of one or more inhalable therapeutic product to a user, the inhaler comprising; a reservoir configured to contain the product for inhalation by the user; a valve movable between a first configuration configured to prevent release of product from the reservoir and a second configuration configured to release a dose of the product from the revoir; a sensor to detect a mechanical input applied to the inhaler during an instance of use; a controller arranged to determine if one or more parameter of the mechanical input meets a predetermined criterion; the controller arranged to log each instance of use by the user, wherein the controller records an indication of whether the parameter of the mechanical input meets the predetermined criterion with the log for an instance of use.

Abstract: Disclosed is an elongate form medicament carrier carrying multiple distinct medicament dose portions. The said carrier has a first end, a second end, a central portion extending across the width of the elongate form medicament carrier, a first portion between the first end and the central portion and containing a medicament active, or a mixture of medicament actives, and a second portion between the second end and the central portion and containing a medicament active, or a mixture of medicament actives. The central portion of the carrier has a first end region, a unified length and a second end region, the unified length has a trailing end connecting to the first portion of the carrier via the first end region and connecting to the second portion of the carrier via the second end region, and the unified length has a leading end connecting to a loop of the central portion of the carrier.

Abstract: A throttle pedal assembly comprises a housing having a first and second side, top, bottom, front and back walls; a main chamber open to the front and bottom of the housing and a sensor cavity. A pedal assembly comprises a pedal, a pedal arm, and a head at an end of the pedal arm rotatable a pivot axis. A magnet is operatively connected to the pedal assembly to rotate on the pivot axis as the pedal assembly rotates about the pivot axis. A Hall effect sensor assembly mounted in the sensor cavity to be proximate the magnet yet separated from the magnet. The cavity and Hall effect sensor assembly are respectively shaped and sized such that the Hall chip and the magnet lay on a common axis such that the Hall chip and the magnet are coaxially aligned. The sensor cavity is sealed to prevent contaminants from entering the cavity.

Abstract: A throttle pedal assembly comprises a housing having a first and second side, top, bottom, front and back walls; a main chamber open to the front and bottom of the housing and a sensor cavity. A pedal assembly comprises a pedal, a pedal arm, and a head at an end of the pedal arm rotatable a pivot axis. A magnet is operatively connected to the pedal assembly to rotate on the pivot axis as the pedal assembly rotates about the pivot axis. A Hall effect sensor assembly mounted in the sensor cavity to be proximate the magnet yet separated from the magnet. The cavity and Hall effect sensor assembly are respectively shaped and sized such that the Hall chip and the magnet lay on a common axis such that the Hall chip and the magnet are coaxially aligned. The sensor cavity is sealed to prevent contaminants from entering the cavity.

Abstract: A solenoid for use with a fuel injector, the solenoid comprising a housing able to be attached to an injector; a core able to be located within the housing; a coil able to be located within the core; and an electrical cable electrically connected to the coil wherein at least the coil and the electrical cable connection to the coil is encapsulated by encapsulant.

Abstract: The present invention provides a flow field plate (separator) for a fuel cell or electrolyser, comprising one or more branched primary fluid delivery/removal channels feeding narrower secondary fluid diffusion channels defined by an array of lands forming a network of interconnected fluid diffusion channels therebetween. The fluid delivery/removal channels and the fluid diffusion channels may be gas delivery/removal channels and gas diffusion channels respectively. The branched fluid delivery channels may simply feed the fluid diffusion channels, which themselves lead directly or via a fluid removal channel to a fluid outlet.

Abstract: The present invention relates to novel compounds of formula (I), to a process for their manufacture, to pharmaceutical compositions containing them, and to their use in therapy, in particular their use in the prophylaxis and treatment of respiratory diseases.

Abstract: The present invention relates to a transmission device implementing a flow control mechanism for aggregate trunks. The transmission device can be implemented as a router that includes an input for receiving aggregate traffic streams, an output for releasing the aggregate traffic streams to a destination point and a control unit capable to regulate the rate of release of packets from the output. Specifically, the flow control operation effected by the control unit is dependent on receipt of acknowledgement messages issued at the destination point, each acknowledgement message confirming the receipt of one or more particular packets at the destination point. The control unit will continuously increase the packet sending rate until a packet is lost in the network between the transmission device and the destination point. On detection of packet loss, based on the lack of one or more corresponding acknowledgement messages from the destination point, the control unit will reduce the packet sending rate.

Abstract: A flow field plate for a fuel cell or electrolyser comprises on at least one face an assembly of channels comprising one or more gas delivery channels, one or more gas removal channels, and a permeable wall separating same. The permeable wall may comprise a plurality of gas diffusion channels.

Abstract: There is described a method of treating, alleviating or preventing the transmission of a sexually transmitted disease which comprises the topical administration of dextrin sulphate. There is also described a composition for use in the treatment, alleviation or prevention of a sexually transmitted disease which comprises dextrin sulphates in gel form.

Abstract: Methods and apparatus for accelerating a router in a communications network are described. In one embodiment, a router accelerator includes a forwarding table for associatively storing a destination address and a next hop address. If a destination address of a packet matches a destination address in the forwarding table, then logic forwards the packet to a next hop. A router may be coupled to at least one network port through the router accelerator. In another approach, the network includes at least one host and at least one router. The host has at least one routing table for associatively storing a second-level destination address, a second-level next hop address and a first-level next hop address. A router accelerator includes redirect logic for storing the second-level destination address in a second-level next hop address entry in the at least one host routing table. This causes the host to request a first-level next hop address corresponding to the second-level destination address.