Abstract: The invention relates to substituted pyrazolo piperidine carboxylic acids, their salts and to processes for their preparation, and also to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, in particular cardiovascular and cardiac diseases, preferably heart failure with reduced and preserved ejection fraction (HFrEF, HFmrEF and HFpEF), hypertension (HTN), peripheral arterial diseases (PAD, PAOD), cardio-renal and kidney diseases, preferably chronic and diabetic kidney disease (CKD and DKD), cardiopulmonary and lung diseases, preferable pulmonary hypertension (PH), and other diseases, preferably neurodegenerative diseases and different forms of dementias, fibrotic diseases, systemic sclerosis (SSc), sickle cell disease (SCD), wound healing disorders such as diabetic foot ulcer (DFU).

Abstract: The invention relates to substituted pyrazolo piperidine carboxylic acids, their salts and to processes for their preparation, and also to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, in particular cardiovascular and cardiac diseases, preferably heart failure with reduced and preserved ejection fraction (HFrEF, HFmrEF and HFpEF), hypertension (HTN), peripheral arterial diseases (PAD, PAOD), cardio-renal and kidney diseases, preferably chronic and diabetic kidney disease (CKD and DKD), cardiopulmonary and lung diseases, preferable pulmonary hypertension (PH), and other diseases, preferably neurodegenerative diseases and different forms of dementias, fibrotic diseases, systemic sclerosis (SSc), sickle cell disease (SCD), wound healing disorders such as diabetic foot ulcer (DFU).

Abstract: An anaerobic reactor system that includes at least one toxicity reduction system that is configured for reducing an amount of one or more nitrogen compound and/or at least one type of recalcitrant in a substrate mixture sufficient to procedure a non-toxic substrate mixture for purposes of anaerobic digestion of the non-toxic substrate.

Abstract: An induced sludge bed anaerobic reactor system that includes at least two stages of bioreactor processing, a first-stage feeding system, a second-stage feeding system, a pH balancing system, an effluent recirculation system, a gas management system, at least one nitrogen reduction system, and a controller. In addition, the nitrogen reduction system(s) if configured for reducing an amount of one or more nitrogen compounds in a substrate mixture sufficient to procedure a non-toxic substrate mixture with respect to anaerobic digestion of the non-toxic substrate by the induced sludge bed anaerobic reactor system.

Abstract: Aspects of the subject disclosure may include, for example, identifying a media program and receiving a digital media stream including metadata and payload data, wherein the payload data includes program content of the identified media program. The metadata further includes program event information and program status information related to the identified media program. A recording status of the identified media program is determined, wherein an active recording status indicates the identified media program is being recorded at a media recorder. Responsive to the active recording status, an end of program is determined according to the identified media program, the program event information and the program status information. Responsive to the end of program, termination of the recording of the media program is initiated. Other embodiments are disclosed.

Abstract: A system. The system includes an image display system, a display device, a camera system, one or more control devices and a control system. The display device is configured to display an image received from the image display system. The camera system is configured to capture the image displayed by the display device during a capture of a scene. The control system is communicably coupled to the image display system, the display device, the camera system and the one or more control devices. The control system comprises a processing circuit and is configured to automatically adjust settings of the image display system, the display device and the camera system. The control system is also configured to determine which of the adjustments results in the least destruction to the image, and apply the adjustment which results in the least destruction to the image.

Abstract: Aspects of the subject disclosure may include, for example, identifying a media program and receiving a digital media stream including metadata and payload data, wherein the payload data includes program content of the identified media program. The metadata further includes program event information and program status information related to the identified media program. A recording status of the identified media program is determined, wherein an active recording status indicates the identified media program is being recorded at a media recorder. Responsive to the active recording status, an end of program is determined according to the identified media program, the program event information and the program status information. Responsive to the end of program, termination of the recording of the media program is initiated. Other embodiments are disclosed.

Abstract: Aspects of the subject disclosure may include, for example, identifying a media program and receiving a digital media stream including metadata and payload data, wherein the payload data includes program content of the identified media program. The metadata further includes program event information and program status information related to the identified media program. A recording status of the identified media program is determined, wherein an active recording status indicates the identified media program is being recorded at a media recorder. Responsive to the active recording status, an end of program is determined according to the identified media program, the program event information and the program status information. Responsive to the end of program, termination of the recording of the media program is initiated. Other embodiments are disclosed.

Abstract: A primary package (10; 110; 210; 310;510; 610; 810) for being lockably received in an outer sleeve (700), the primary package comprising a main body panel (12; 112; 212; 312; 512; 612; 812) and a retention tab (14; 114; 214; 314; 512; 612; 812) hingedly connected together along a fold line (17; 117; 217; 317; 517; 617; 817), the retention tab having at least one embossment (18; 118; 218; 318; 518; 618; 818), the fold line having been integrally formed in the primary package.

Abstract: An induced sludge bed anaerobic reactor system that includes at least two stages of bioreactor processing, a first-stage feeding system, a second-stage feeding system, a pH balancing system, an effluent recirculation system, a gas management system, at least one nitrogen reduction system, and a controller. In addition, the nitrogen reduction system(s) if configured for reducing an amount of one or more nitrogen compounds in a substrate mixture sufficient to procedure a non-toxic substrate mixture with respect to anaerobic digestion of the non-toxic substrate by the induced sludge bed anaerobic reactor system.

Abstract: An induced sludge bed anaerobic reactor system that includes at least two stages of bioreactor processing, a first-stage feeding system, a second-stage feeding system, a pH balancing system, an effluent recirculation system, a gas management system, and a controller. In addition, any given stage of reactor processing may be comprised of a plurality of reactors that are configured to operate in parallel with each other.

Abstract: Aspects of the subject disclosure may include, for example, identifying a media program and receiving a digital media stream including metadata and payload data, wherein the payload data includes program content of the identified media program. The metadata further includes program event information and program status information related to the identified media program. A recording status of the identified media program is determined, wherein an active recording status indicates the identified media program is being recorded at a media recorder. Responsive to the active recording status, an end of program is determined according to the identified media program, the program event information and the program status information. Responsive to the end of program, termination of the recording of the media program is initiated. Other embodiments are disclosed.

Abstract: Aspects of the subject disclosure may include, for example, identifying a media program and receiving a digital media stream including metadata and payload data, wherein the payload data includes program content of the identified media program. The metadata further includes program event information and program status information related to the identified media program. A recording status of the identified media program is determined, wherein an active recording status indicates the identified media program is being recorded at a media recorder. Responsive to the active recording status, an end of program is determined according to the identified media program, the program event information and the program status information. Responsive to the end of program, termination of the recording of the media program is initiated. Other embodiments are disclosed.

Abstract: An induced sludge bed anaerobic reactor system that includes at least two stages of bioreactor processing, a first-stage feeding system, a second-stage feeding system, a pH balancing system, an effluent recirculation system, a gas management system, and a controller. In addition, any given stage of reactor processing may be comprised of a plurality of reactors that are configured to operate in parallel with each other.

Abstract: An induced sludge bed anaerobic reactor system that includes at least two stages of bioreactor processing, a first-stage feeding system, a second-stage feeding system, a pH balancing system, an effluent recirculation system, a gas management system, and a controller. In addition, any given stage of reactor processing may be comprised of a plurality of reactors that are configured to operate in parallel with each other.

Abstract: Aspects of the subject disclosure may include, for example, identifying a media program and receiving a digital media stream including metadata and payload data, wherein the payload data includes program content of the identified media program. The metadata further includes program event information and program status information related to the identified media program. A recording status of the identified media program is determined, wherein an active recording status indicates the identified media program is being recorded at a media recorder. Responsive to the active recording status, an end of program is determined according to the identified media program, the program event information and the program status information. Responsive to the end of program, termination of the recording of the media program is initiated. Other embodiments are disclosed.

Abstract: An induced sludge bed anaerobic reactor system that includes at least two stages of bioreactor processing, a first-stage feeding system, a second-stage feeding system, a pH balancing system, an effluent recirculation system, a gas management system, and a controller. In addition, any given stage of reactor processing may be comprised of a plurality of reactors that are configured to operate in parallel with each other.

Abstract: A primary package (10; 110; 210; 310; 510; 610; 810) for being lockably received in an outer sleeve (700), the primary package comprising a main body panel (12; 112; 212; 312; 512; 612; 812) and a retention tab (14; 114; 214; 314; 512; 612; 812) hingedly connected together along a fold line (17; 117; 217; 317; 517; 617; 817), the retention tab having at least one embossment (18; 118; 218; 318; 518; 618; 818), the fold line having been integrally formed in the primary package.

Abstract: A method of manufacturing a section is formed from a blank having the perimeter of a truncated generally isosceles triangle. Each angled side of the truncated generally isosceles triangle includes a plurality of substantially semi-circular channels. The long axis of each substantially semi-circular channel is substantially parallel to the base of the truncated generally isosceles triangle. The top of the substantially semi-circular channel intersects the front surface of the section knife. The bottom of the substantially semi-circular channel intersects the back surface of the section knife. A cutting edge is formed at the intersection of the substantially semi-circular channel and the back surface of the section knife.

Abstract: A primary package (10; 110; 210; 310; 510; 610; 810) for being lockably received in an outer sleeve (700), the primary package comprising a main body panel (12; 112; 212; 312; 512; 612; 812) and a retention tab (14; 114; 214; 314; 512; 612; 812) hingedly connected together along a fold line (17; 117; 217; 317; 517; 617; 817), the retention tab having at least one embossment (18; 118; 218; 318; 518; 618; 818), the fold line having been integrally formed in the primary package.