Abstract: The present invention provides 6-substituted 2,3,4,5-tetrahydro-1H-benzo[d]azepines of Formula I as selective 5-HT2C receptor agonists for the treatment of 5-HT2C associated disorders including obesity, obsessive/compulsive disorder, depression, and anxiety: Formula (I) where: R6 is selected from the group consisting of (a, b, c, d, e) and other substituents are as defined in the specification.

Abstract: The present invention provides 6-substituted 2,3,4,5-tetrahydro-1H-benzo[d]azepines of Formula I as selective 5-HT2C receptor agonists for the treatment of 5-HT2C associated disorders including obesity, obsessive/compulsive disorder, depression, and anxiety: Formula (I) where: R6 is selected from the group consisting of (a, b, c, d, e) and other substituents are as defined in the specification.

Abstract: An orthopedic reaming instrument has an elongate member and a reaming member disposed on a distal end of the elongate member. The reaming member includes a distal apical region in the form of a partial sphere having an arc of less than 180.degree. and a proximal cylindrical region. An acetabular instrumentation system has an acetabular prosthesis in the form of a partial sphere having an arc of less than or equal to 180.degree. and an acetabular reamer which includes a distal apical region in the form of a partial sphere having an arc that is less than the arc of the prosthesis.

Abstract: A modular acetabular reinforcement system includes a substantially cup-shaped reinforcement body having a peripheral flange portion. One or more fixation wings, of various sizes and shapes, are selectively and separately attachable to the flange portion of the reinforcement body. The system is mountable within the acetabulum of a patient to reinforce the acetabulum and to serve as a platform for other prosthesis components such as an acetabular shell.

Abstract: A treatment system for natural leaf tobacco wrapper is provided for comprising in combination:(a) a humectant/plasticizer component;(b) a preservative component;(c) a solvent carrier selected from the group comprising water and water/alcohol mixtures; and(d) optionally, a polymeric film-forming component selected from the group comprising synthetic gums, natural gums and protein film-forming compositions.

Abstract: A filter cigar is provided having outer layers of cigar wrapper and binder material each spirally wrapped about a preformed cigar filter and tobacco filler charge. A reinforcement strip including layers of high wet strength reinforcing tape and bonded to the binder is circumferentially wrapped over the interface between the filter and the filler charge.