Abstract: A process for the manufacture of the (−) trans piperidine carbinol (1) by a process comprising contacting a racemic mixture of the piperidine carbinol in solution with (−)-ditoluoyltartaric acid, crystallising the (−) -ditoluoyltartaric acid salt of the piperidine carbinol, isolating the crystalline salt and neutralising the crystalline salt to regenerate the (−) trans isomer of the piperidine carbinol and the (−)-ditoluoyltartaric acid, which is characterised by one or more of the following steps: (1) combining solutions of the racemic piperidine carbinol and (−)-ditoluoyltartaric acid in acetone so that the combined solution contains 2-3 % wt/wt of water, (2) consolidating the chiral salt crystallisation at from 30 to 40° C., (3) cooling the crystallisation mixture to from 3 to 7° C. before isolating the chiral salt, (4) regenerating the (−) trans piperidine carbinol at a pH of from 10.5 to 11.

Abstract: A smooth-surfaced tape or sheet of composite syntactic material made up of a polyolefin and, as filler, hollow microspheres, is formed by extrusion through a die having a land length to thickness ratio less than 7:1 at a temperature of about 215.degree. C. Such tapes are wrapped around pipes to provide insulation.

Abstract: Two further crystalline polymorphic forms of the anti-infective agent mupirocin have been identified. Processes for the preparation thereof and the use thereof are described.

Abstract: This invention relates to a novel salt of an antibacterial compound and to a process for its preparation.

Abstract: The invention provides crystalline paroxetine hydrochloride hemihydrate, processes for its preparation, compositions containing the same and its therapeutic use as an anti-depressant.

Abstract: This invention provides a novel process for the preparation of clavulanic acid and pharmaceutically acceptable salts and esters thereof which process utilizes the preparation of the tertiary-butylamine salt of clavulanic acid optionally in the form of an acetone solvate and subsequently converting said salt into the desired product.

Abstract: Procedure for isolating lithium pseudomonate from a crude preparation containing pseudomonic acid by extracting the crude preparation into a suitable organic solvent in which pseudomonic acid is soluble, treating the extract with a lithium alkanoic acid and separating the resulting crystalline non-hygroscopic lithium pseudomonate, the crude preparation containing pseudomonic acid being a culture medium on or in which pseudomonic acid producing strains of bacteria have been grown, such as Pseudomonas fluorescens.

Abstract: This invention provides a novel process for the preparation of clavulanic acid and pharmaceutically acceptable salts and esters thereof which process utilizes the preparation of the tertiary-butylamine salt of clavulanic acid optionally in the form of an acetone solvate and subsequently converting said salt into the desired product.