Patents by Inventor Alan D. T. Barrett

Alan D. T. Barrett has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • NOVEL ATTENUATED VIRUS STRAINS AND USES THEREOF
    Publication number: 20090117149
    Abstract: Methods and compositions concerning mutant flaviviruses with reduced virulence. In some embodiments the invention concerns nucleotide sequences that encode mutant flaviviral proteins. Viruses comprising mutant NS1 and NS4B genes display reduced virulence are provided. In further aspects of the invention, flavivirus vaccine compositions such as West Nile virus vaccines are provided. In another embodiment the invention provides methods for vaccination against flavivirus infection.
    Type: Application
    Filed: July 14, 2006
    Publication date: May 7, 2009
    Applicant: Research Development Foundation
    Inventors: Jason A. Wicker, Melissa C. Whiteman, Alan D.T. Barrett
  • Flavivirus variants having phenotypic variation and immunogenic compositions thereof
    Patent number: 7482017
    Abstract: The present invention concerns isolated attenuated flaviviruses , such as West Nile viruses, having modifications that provide phenotypic varation, particularly in comparison to a more virulent reference strains. The invention encompasses the isolated viruses and immunogenic compositions thereof, in addition to methods to produce and utilize same.
    Type: Grant
    Filed: September 9, 2005
    Date of Patent: January 27, 2009
    Assignee: Research Development Foundation
    Inventors: Alan D. T. Barrett, Robert B. Tesh, C. Todd Davis, David W. C. Beasley
  • Nucleotide sequence of the nucleocapsid gene of oropouche virus
    Patent number: 6320027
    Abstract: The present invention provides DNA encoding an Oropouche NP protein selected from the group consisting of: (a) isolated DNA which encodes an Oropouche NP protein; (b) isolated DNA which hybridizes to isolated DNA of (a) above and which encodes an Oropouche NP protein; and (c) isolated DNA differing from the isolated DNAs of (a) and (b) above in codon sequence due to the degeneracy of the genetic code, and which encodes an Oropouche NP protein. Also provided is a kit for the immunodetection of Oropouche virus.
    Type: Grant
    Filed: January 14, 2000
    Date of Patent: November 20, 2001
    Assignee: The Board of Regents of the University of Texas
    Inventors: Alan D. T. Barrett, Mohammad F. Saeed, Robert B. Tesh, Robert E. Shope, Heiman Wang
  • Non-antibiotic system for selection of recombinant mycobacteria
    Patent number: 5895756
    Abstract: The present invention provides a Mycobacterium-E. coli shuttle vector containing sequences coding for a tribrid fusion containing the M. leprae 18kDa antigen sequence, a phoA protein antigen sequence and a non-mycobacterial, non-E.coli heterologous protein antigen sequence. Also provided is a method of producing protective immunity in an animal or human host in need of such treatment, comprising the step of administering to said animal or human host an effective dose of recombinant mycobacteria carrying the vector of the present invention.
    Type: Grant
    Filed: April 11, 1997
    Date of Patent: April 20, 1999
    Assignee: The Board of Trustees of the University of Texas System
    Inventors: Alan D. T. Barrett, David Niesel, Christopher Robb, Haolin Ni