Abstract: A method and apparatus for preventing and treating septicemia in patient blood is provided. The extracorporeal system includes an antimicrobial device to inactivate at least 99% of bloodborne microorganisms, a hemoconcentrator/filtration unit to remove approximately 50-75% of target molecules from the patient blood and a filter unit to remove target molecules from patient blood from the sieved plasma filtrate. Target molecules are produced by microorganisms, as well as by the patient's cells. These molecules include endotoxins from Gram negative bacteria, exotoxins from Gram negative and Gram positive bacteria, as well as RAP protein mediator from Staphylococcus aureus, and cell mediators such as tumor necrosis factor-alpha, and interleukin 1-beta, interleukin 6, complement proteins C3a and C5a, and bradykinin.

Abstract: A method and apparatus for preventing and treating septicemia in patient blood is provided. The extracorporeal system includes an antimicrobial device to inactivate at least 99% of bloodborne microorganisms, a hemoconcentrator/filtration unit to remove approximately 50-75% of target molecules from the patient blood and a filter unit to remove target molecules from patient blood from the sieved plasma filtrate. Target molecules are produced by microorganisms, as well as by the patient's cells. These molecules include endotoxins from Gram negative bacteria, exotoxins from Gram negative and Gram positive bacteria, as well as RAP protein mediator from Staphylococcus aureus, and cell mediators such as tumor necrosis factor-alpha, and interleukin 1-beta, interleukin 6, complement proteins C3a and C5a, and bradykinin.

Abstract: A method and apparatus for retroperfusing cerebral venous vasculature with autologous venous blood through a percutaneous entry site which incorporates a double-lumen catheter, a self-inflating pressure-regulated balloon mounted on the catheter and a perfusion outflow region either distal to the balloon for direct perfusion into the superior sagittal sinus, or proximal to the balloon for perfusion into the transverse sinus near the junction of the superior sagittal sinus.

Abstract: A method and apparatus for preventing and treating septicemia in patient blood. The extracorporeal system includes an anti-microbial device to kill at least 99% of bloodborne microorganisms, a hemoconcentrator/filtration unit to remove approximately 90% of target molecules from the patient blood and a filter unit to remove target molecules from patient blood from the sieved plasma filtrate. Target molecules are produced by microorganisms as well as the patient's cells and include endotoxins from gram negative bacteria, exotoxins from gram negative and gram positive bacteria, as well as RAP protein mediator from Staphylococcus aureus, and cell mediators such as tumor necrosis factor-alpha, and interleukin 1-beta, complement proteins C3a and C5a, and brandykinin.

Abstract: Leakage of blood from the insertion set, during and after safety-needle retraction, is suppressed by components that receive and retain flash blood for viewing--notwithstanding forces developed within the device in retraction. One preferred such system includes a flash chamber that moves with the retracting needle, within a hollow handle, carrying a relatively high flow-impedance element which allows air exhaust from the chamber into the handle to admit flash blood--but isolates blood in the chamber from retraction-generated increase in air pressure in the handle. Energy-absorbing components control or compensate for retraction speed, to provide quiet smooth retraction--while yet enabling use of ample retraction force to make retraction reliable. Among several energy absorbing systems disclosed is a preferred one that includes a viscous material introduced within the hollow handle to damp the retracting motion; and an injection port to facilitate introduction of the viscous material.

Abstract: Leakage of blood from the insertion set, during and after safety-needle retraction, is suppressed by components that receive and retain flash blood for viewing--notwithstanding forces developed within the device in retraction. One preferred such system includes a flash chamber that moves with the retracting needle, within a hollow handle, carrying a relatively high flow-impedance element which allows air exhaust from the chamber into the handle to admit flash blood--but isolates blood in the chamber from retraction-generated increase in air pressure in the handle. Energy-absorbing components control or compensate for retraction speed, to provide quiet smooth retraction--while yet enabling use of ample retraction force to make retraction reliable. Among several energy absorbing systems disclosed is a preferred one that includes a viscous material introduced within the hollow handle to damp the retracting motion; and an injection port to facilitate introduction of the viscous material.

Abstract: Disclosed is a multimodal method and apparatus for extracorporeally treating certain blood borne infections, such as the infection of T-lymphocytes with the Human Immunodeficiency Virus. The method and apparatus of the invention includes (a) hyperthermic, (b) mechanical shear inducing, and (c) irradiation treatment modalities. These three treatment modalities may be carried out separately, in any order, or simultaneously, in any combination. The irradiation treatment mode preferably includes methods and means for subjecting at least a fraction of the blood to ultraviolet and/or x-ray and/or laser radiation. Before the blood is withdrawn from the human subject a chemical agent such as heparin may be administered to the subject for purposes of inducing lymphocyte migration from the lymph system into the circulatory system.

Abstract: Disclosed is a multimodal method and apparatus for extracorporeally treating certain blood borne infections, such as the infection of T-lymphocytes with the Human Immunodeficiency Virus. The method and apparatus of the invention includes (a) hyperthermic, (b) mechanical shear inducing, and (c) irradiation treatment modalities. These three treatment modalities may be carried out separately, in any order, or simultaneously, in any combination. The irradiation treatment mode preferably includes methods and means for subjecting at least a fraction of the blood to ultraviolet and/or x-ray and/or laser radiation. Before the blood is withdrawn from the human subject a chemical agent such as heparin may be administered to the subject for purposes of inducing lymphocyte migration from the lymph system into the circulatory system.

Abstract: A filter device used to filter medical anesthesia gases and other inhalable respiratory gases. The filter device has a ported housing, and a filter member within the housing. The filter member is a porous sheet that is transversely pleated and draped to define a peripheral foot of such porous sheet. The peripheral foot is sealed along its entire periphery to the housing. Two sets of intermeshing hangers are provided with both sets of the hangers being anchored to the housing and distortingly maintaining the porous sheet in such a pleated condition.