Abstract: A trailer includes a trailer frame having a hitch. A stationary support base is joined to the trailer frame. Two supports are slidably guided on the support base toward and away from each other. A wheel assembly is mounted to an end of each of the supports remote from the other support such that a distance between the wheel assemblies varies with movement of the supports on the support base. A locking device selectively locks each support to the support base in a first position where the wheel assemblies are furthest from each other and a second position where the wheel assemblies are closer to each other.

Abstract: The present invention is related to the field of CRISPR-Cas9 gene editing platforms. In particular, the present invention has identified Type II-C Cas9 anti-CRISPR (Acr) inhibitors that control Cas9 gene editing activity. Co-administration of such Acr inhibitors may provide an advantageous adjunct in permitting safe and practical biological therapeutics through spatial or temporal control of Cas9 activity; controlling Cas9-based gene drives in wild populations to reduce the ecological consequences of such forced inheritance schemes; and contributing to general research into various biotechnological, agricultural, and medical applications of gene editing technologies.

Abstract: The present invention is related to the field of CRISPR-Cas9 gene editing platforms. In particular, the present invention has identified Type II-C Cas9 anti-CRISPR (Acr) inhibitors that control Cas9 gene editing activity. Co-administration of such Acr inhibitors may provide an advantageous adjunct in permitting safe and practical biological therapeutics through spatial or temporal control of Cas9 activity; controlling Cas9-based gene drives in wild populations to reduce the ecological consequences of such forced inheritance schemes; and contributing to general research into various biotechnological, agricultural, and medical applications of gene editing technologies.

Abstract: The present disclosure provides compositions and methods for introducing or enhancing Aca activity in prokaryotic cells. The provided compositions and methods can be used to inhibit Acr activity in prokaryotic cells, thereby enhancing endogenous or exogenous CRISPR-Cas activity. Cells, polynucleotides, plasmids, phage, and other elements for practicing the present methods are also provided.

Abstract: Exemplary embodiments of the present disclosure relate to systems, methods, and non-transitory computer-readable media for contemporaneous in-browser searching, viewing, tagging, comparison, and harvesting of specific elements in digital content in a networked environment via enhanced browser environment, and for refining an operation of a portal based on the contemporaneous in-browser searching, viewing, tagging, comparison and harvesting of elements in digital content.

Abstract: Disclosed herein are compounds, salts, solvates of Formula (1), and any formulation thereof. Also disclosed are methods of eliciting hydraulic enhancement and/or increasing yield of a plant by contacting a plant with compounds, salts, solvates of Formula (1), or any formulation thereof.

Abstract: A trailer includes a trailer frame having a hitch. A stationary support base is joined to the trailer frame. Two supports are slidably guided on the support base toward and away from each other. A wheel assembly is mounted to an end of each of the supports remote from the other support such that a distance between the wheel assemblies varies with movement of the supports on the support base. A locking device selectively locks each support to the support base in a first position where the wheel assemblies are furthest from each other and a second position where the wheel assemblies are closer to each other.

Abstract: Exemplary embodiments of the present disclosure relate to systems, methods, and non-transitory computer-readable media for contemporaneous in-browser searching, viewing, tagging, and harvesting digital content in a networked environment, and for removing malignant content from the networked environment.

Abstract: A trailer includes a trailer frame having a hitch. A stationary support base is joined to the trailer frame. Two support plates are slidably guided on the support base toward and away from each other. A pair of wheel assemblies is provided, wherein a wheel assembly is mounted to an end of each of the support plates remote from the other support plate such that a distance between the wheel assemblies varies with movement of the support plates on the support base. A pair of drive links is provided wherein a drive link is joined to each of the support plates. A drive mechanism is joined to the drive links and configured to selectively move the support plates toward or away from each other.

Abstract: The present invention is related to the field of CRISPR-Cas9 gene editing platforms. In particular, the present invention has identified Type II-C Cas9 anti-CRISPR (Acr) inhibitors that control Cas9 gene editing activity. Co-administration of such Acr inhibitors may provide an advantageous adjunct in permitting safe and practical biological therapeutics through spatial or temporal control of Cas9 activity; controlling Cas9-based gene drives in wild populations to reduce the ecological consequences of such forced inheritance schemes; and contributing to general research into various biotechnological, agricultural, and medical applications of gene editing technologies.

Abstract: A transportable fold-out structure includes a support frame. First and second primary platforms are pivotally supported by the support frame and each is disposed in an upright position wherein the platform extends upwardly. Two wall assemblies are disposed opposite each other. Each wall assembly includes a plurality of wall segments joined together. Each wall segment is pivotally joined to the support frame or one of the primary platforms. Each wall assembly is movable from a first position wherein the wall assembly is lying above the first and second primary platforms to a second position wherein the two wall assemblies face each other. First and second extensions are configured to be selectively positionable wherein a first portion of the extension is connected to the support frame and a second portion of the extension is remote from the corresponding first portion and extends laterally from the support frame.

Abstract: Exemplary embodiments of the present disclosure relate to systems, methods, and non-transitory computer-readable media for contemporaneous in-browser searching, viewing, tagging, and harvesting digital content in a networked environment, and for removing malignant content from the networked environment.

Abstract: Exemplary embodiments of the present disclosure relate to systems, methods, and non-transitory computer-readable media for contemporaneous in-browser searching, viewing, tagging, and harvesting digital content in a networked environment, and for removing malignant content from the networked environment.

Abstract: Disclosed herein are compounds, salts, solvates of Formula (1), and any formulation thereof. Also disclosed are methods of eliciting hydraulic enhancement and/or increasing yield of a plant by contacting a plant with compounds, salts, solvates of Formula (1), or any formulation thereof.

Abstract: Exemplary embodiments of the present disclosure relate to systems, methods, and non-transitory computer-readable media for contemporaneous in-browser searching, viewing, tagging, comparison, and harvesting of specific elements in digital content in a networked environment via enhanced browser environment, and for refining an operation of a portal based on the contemporaneous in-browser searching, viewing, tagging, comparison and harvesting of elements in digital content.

Abstract: A transportable fold-out structure includes a support frame. First and second primary platforms are pivotally supported by the support frame and each is disposed in an upright position wherein the platform extends upwardly. Two wall assemblies are disposed opposite each other. Each wall assembly includes a plurality of wall segments joined together. Each wall segment is pivotally joined to the support frame or one of the primary platforms. Each wall assembly is movable from a first position wherein the wall assembly is lying above the first and second primary platforms to a second position wherein the two wall assemblies face each other. First and second extensions are configured to be selectively positionable wherein a first portion of the extension is connected to the support frame and a second portion of the extension is remote from the corresponding first portion and extends laterally from the support frame.

Abstract: Exemplary embodiments of the present disclosure relate to systems, methods, and non-transitory computer-readable media for contemporaneous in-browser searching, viewing, tagging, and harvesting digital content in a networked environment, and for removing malignant content from the networked environment.

Abstract: A trailer includes at least a plurality of fabric support connections that retain a plurality of fabrics spaced apart from one another so as, if desired, to insulate the roof and side walls of the trailer. In one embodiment, the plurality of fabric support connections are connected by way of extrusions to some of the sides of the trailer and further provide insulation by forming a double wall on those sides. In another embodiment, the plurality of fabric support connections form a double wall only on certain portions of the top side of the trailer.