Abstract: Patients diagnosed with a cancer harboring an IDH-1 mutation can be treated by the administration of a therapeutically effective amount of a pharmaceutical composition comprising Compound 1, a selective inhibitor of 2-HG production from mIDH-1 enzymes including the R132 mutations R132C, R132H, R132L, R132G, and R132S.

Abstract: An ear tip has an inner part connectable to an ear bud body of an earbud, and an outer part disposed at least partially over the inner part. The outer part is flexible and is for coupling the ear tip to a user's ear canal. The inner part includes an inwardly facing wall and an outwardly facing wall, the inner wall defining at least part of a primary sound communication path between the ear canal and the ear bud body. The inner part includes at least one tip vent that defines an ambient sound communication path between the inwardly facing wall and the outwardly facing wall, and thereby the user's ear canal and ambient. The inner part provides an acoustic impedance to sound passing through the at least one tip vent and thereby defined sound characteristics in the ambient audio communication path. An ear bud is also described.

Abstract: Patients diagnosed with a cancer harboring an IDH-1 mutation can be treated by the administration of a therapeutically effective amount of a pharmaceutical composition comprising Compound 1, a selective inhibitor of 2-HG production from mIDH-1 enzymes including the R132 mutations R132C, R132H, R132L, R132G, and R132S.

Abstract: A hearing assistance system is disclosed that comprises a hearing assistance device configured to reproduce sounds and to assist a person to hear the sounds, the hearing assistance device including a left hearing assistance device and a right hearing assistance device, and a computing device in communication with the hearing assistance device. The computing device interacts with the hearing assistance device to implement a fitting mode wherein the hearing assistance device is caused to generate fitting sounds usable to evaluate whether the left and right hearing devices are properly fitted into respective left and right ears of the person. The computing device produces a communication indicative of whether the left and right hearing assistance devices are properly fitted into respective left and right ears of the person.

Abstract: A wellhead alignment system includes a visual marker configured to be placed at a wellhead and a camera configured to capture an image that includes the visual marker. The wellhead alignment system also includes one or more processors configured to apply computer vision algorithms to identify the visual marker in the image and to calculate an offset between the wellhead and a drilling rig based on a position of the visual marker in the image.

Abstract: Provided is a food composition which include a myceliated high-protein food product and methods to make such compositions, which are mixtures of myceliated high-protein food products and other edible materials. A food composition includes dairy alternative products, ready to mix beverages and beverage bases; extruded and extruded/puffed products; sheeted baked goods; meat analogs and extenders; baked goods and baking mixes; granola; and soups/soup bases. Food compositions also include texturized plant protein which can be used for making meat-structured plant protein meat analog or meat extender products. The food compositions have reduced undesirable flavors and reduced undesirable aromas due to use of myceliated high-protein food products as compared to use of similar high-protein material that is not myceliated.

Abstract: A processor with instruction storage configured to store processor instructions, data storage configured to store processor data representing an array, the array including plural data elements, a controller, and an instruction pipeline. The instruction pipeline includes: a load stage circuit configured to load an array element from the data storage, a compare stage circuit configured to compare the array element to a reference value, a store stage circuit configured to store a set of results that includes a result of the comparison of the array element to the reference value, and a loop hit detect stage circuit configured to determine whether any of the set of results is associated with a hit on the reference value.

Abstract: Systems, methods, and computer-readable media are described for compact radar systems. In some examples, a compact radar system can include a first set of transmit antennas, a second set of receive antennas, one or more processors, and at least one computer-readable storage medium storing computer-executable instructions which, when executed by the one or more processors, cause the radar system to coordinate digital beam steering of the first set of transmit antennas and the second set of receive antennas, and coordinate digital beam forming with one or more of the second set of receive antennas to detect one or more objects within a distance of the radar system.

Abstract: A system provides integrated evaluations within executed workflow interactions. The system receives a query from a user device during an interaction between the user device and an agent device. The system determines a query intent, and based on a determination that a workflow is available in a database, executes the workflow. The system integrates an evaluation with in the workflow by transmitting a request for an input to the user device. The system displays rating options associated with the input in an interaction window. The system receives a rating selection based on one of the rating options and executes a response action corresponding to the rating selection.

Abstract: A method for activating a catalyst is described comprising the steps of: (i) installing a reduced and passivated catalyst containing crystallites of a catalytic metal comprising nickel, cobalt or iron in elemental form encapsulated by a layer comprising an oxide of the catalytic metal in a reactor, such as a steam methane reforming reactor, in which it is to be used, and (ii) heating the reduced and passivated catalyst in the reactor under a vacuum or an inert gas to a temperature in the range (TT?X) to (TT+Y), where TT is the Tammann temperature of the catalytic metal in elemental form in degrees Centigrade, X is 400 and Y is 200, to form a catalytically active surface on the catalyst without requiring the application of a reducing gas.

Abstract: A sleeve apparatus for weighting a structure, such as a canopy structure, that can also be used to display items on the structure via the items' attachment to the sleeve apparatus. The sleeve apparatus includes at least an elongated body having first and second ends, a first connector element connected to the first end of the elongated body that is capable of encircling and attaching to a rod member and/or a bar member and a second connector element connected to and extending from the second end of the elongated body that is capable of encircling and attaching to the same or a different rod member and/or bar member.

Abstract: A method and system device provides a unique object identification process by obtaining information from one or more of radar signals, infrared signals, optical signals, audio signals, and other signals. The method includes continuously receiving object data at the device, applying by a machine learning system, a set of parameters to process the object identification and confidence level, and outputting or updating the object identification, confidence level, and actionable recommendations. The radar data includes a Doppler signature having a wrapped signal due to a sampling rate of the radar system. The Doppler signature is used to train the machine learning system to identify drone types.

Abstract: A system is disclosed for configuring a hearing device. The system includes an audiogram processing component arranged to process image data indicative of an image of an audiogram associated with a person so as to produce audiogram data indicative of the audiogram, and a hearing device configuration component arranged to produce hearing device configuration data based on the audiogram data. The configuration data is indicative of configuration settings for a hearing device that will cause the hearing device to assist the hearing of the person.

Abstract: A digital data processor includes an instruction memory storing instructions each specifying a data processing operation and at least one data operand field, an instruction decoder coupled to the instruction memory for sequentially recalling instructions from the instruction memory and determining the data processing operation and the at least one data operand, and at least one operational unit coupled to a data register file and to an instruction decoder to perform a data processing operation upon at least one operand corresponding to an instruction decoded by the instruction decoder and storing results of the data processing operation. The operational unit is configured to increment histogram values in response to a histogram instruction by incrementing a bin entry at a specified location in a specified number of at least one histogram.

Abstract: A beverage holder includes a frame, an insert, and a cover. The frame includes a sidewall having an upper end and a lower end, and a bottom wall extending across the lower end. The upper end defines a plurality of protrusions. The sidewall and the bottom wall cooperatively define a chamber. The insert includes a peripheral rim defining a plurality of apertures that receive the plurality of protrusions and a flexible collar extending from the peripheral rim and at least partially into the chamber. The flexible collar defines an opening leading to the chamber. The cover includes a plurality of interfaces that engage with the plurality of protrusions to couple the cover to the upper end of the sidewall and to secure the insert between the frame and the cover. The cover defines an aperture that aligns with the chamber and the opening.

Abstract: A sleeve apparatus for weighting a structure, such as a canopy structure, that can also be used to display items on the structure via the items' attachment to the sleeve apparatus. The sleeve apparatus includes at least an elongated body having first and second ends, a first connector element connected to the first end of the elongated body that is capable of encircling and attaching to a rod member and/or a bar member and a second connector element connected to and extending from the second end of the elongated body that is capable of encircling and attaching to the same or a different rod member and/or bar member.

Abstract: A wellhead alignment system includes a visual marker configured to be placed at a wellhead and a camera configured to capture an image that includes the visual marker. The wellhead alignment system also includes one or more processors configured to apply computer vision algorithms to identify the visual marker in the image and to calculate an offset between the wellhead and a drilling rig based on a position of the visual marker in the image.

Abstract: An audio system has a speaker port defining a speaker port cavity, which has a speaker port outlet communicating acoustically with a user's ear canal. A speaker generates output sound in the speaker port cavity based on a speaker signal received at the speaker. The output sound travels along an acoustic path extending from the speaker through the speaker port outlet to an ear canal. A speaker port microphone in acoustic communication with the speaker port cavity produces a speaker port microphone signal in response to input sound. An analysis unit receives the speaker signal and the speaker port microphone signal, uses the speaker signal and the speaker port microphone signal to determine a change in acoustic properties of the acoustic path, and uses the determined change in acoustic properties of the acoustic path to determine a change in physical properties of the audio system along the acoustic path.

Abstract: An ammunition bucket may be provided for preparation of ammunition for toy blasters having greater ease of use with less mess. The bucket may be collapsible having sides that collapse in an accordion style, and the bucket may include a carrying handle. The lid may be sealed and resistant to splashing and leakage. A lower recessed port area may be provided at the lowest portion of the bucket body. This port may be a three-way drain and strain port. The lower recessed port area may include a dispensing valve with a primary control notch and a flap that provides rate control for the valve. The dispensing valve also may include a secondary control notch that limits an opening of the dispensing valve to prevent ammunition from leaving the bucket.

Abstract: A digital data processor includes an instruction memory storing instructions each specifying a data processing operation and at least one data operand field, an instruction decoder coupled to the instruction memory for sequentially recalling instructions from the instruction memory and determining the data processing operation and the at least one data operand, and at least one operational unit coupled to a data register file and to an instruction decoder to perform a data processing operation upon at least one operand corresponding to an instruction decoded by the instruction decoder and storing results of the data processing operation. The operational unit is configured to increment histogram values in response to a histogram instruction by incrementing a bin entry at a specified location in a specified number of at least one histogram.