Abstract: This disclosure is directed to systems and methods for the delivery and maintenance of faxes where the faxes may remain at a faxing system for a minimal amount of time. The faxing system may send a queued fax to a connector responsive to a request from the connector to pull or retrieve a fax. The connector is configured to send a release notification to the faxing system after the fax is received. The faxing system is configured to delete the queued fax as soon as confirmation of the delivery of the fax can be determined or when an expiration time has elapsed.

Abstract: This disclosure is directed to systems and methods for the delivery and maintenance of faxes where the faxes may remain at a faxing system for a minimal amount of time. The faxing system may send a queued fax to a connector responsive to a request from the connector to pull or retrieve a fax. The connector is configured to send a release notification to the faxing system after the fax is received. The faxing system is configured to delete the queued fax as soon as confirmation of the delivery of the fax can be determined or when an expiration time has elapsed.

Abstract: This disclosure is directed to systems and methods for the delivery and maintenance of faxes where the faxes may remain at a faxing system for a minimal amount of time. The faxing system may send a queued fax to a connector responsive to a request from the connector to pull or retrieve a fax. The connector is configured to send a release notification to the faxing system after the fax is received. The faxing system is configured to delete the queued fax as soon as confirmation of the delivery of the fax can be determined or when an expiration time has elapsed.

Abstract: This disclosure is directed to systems and methods for the delivery and maintenance of faxes where the faxes may remain at a faxing system for a minimal amount of time. The faxing system may send a queued fax to a connector responsive to a request from the connector to pull or retrieve a fax. The connector is configured to send a release notification to the faxing system after the fax is received. The faxing system is configured to delete the queued fax as soon as confirmation of the delivery of the fax can be determined or when an expiration time has elapsed.

Abstract: This disclosure is directed to systems and methods for the delivery and maintenance of faxes where the faxes may remain at a faxing system for a minimal amount of time. The faxing system may send a queued fax to a connector responsive to a request from the connector to pull or retrieve a fax. The connector is configured to send a release notification to the faxing system after the fax is received. The faxing system is configured to delete the queued fax as soon as confirmation of the delivery of the fax can be determined or when an expiration time has elapsed.

Abstract: This disclosure is directed to systems and methods for the delivery and maintenance of faxes where the faxes may remain at a faxing system for a minimal amount of time. The faxing system may send a queued fax to a connector responsive to a request from the connector to pull or retrieve a fax. The connector is configured to send a release notification to the faxing system after the fax is received. The faxing system is configured to delete the queued fax as soon as confirmation of the delivery of the fax can be determined or when an expiration time has elapsed.

Abstract: This disclosure is directed to systems and methods for the delivery and maintenance of faxes where the faxes may remain at a faxing system for a minimal amount of time. The faxing system may send a queued fax to a connector responsive to a request from the connector to pull or retrieve a fax. The connector is configured to send a release notification to the faxing system after the fax is received. The faxing system is configured to delete the queued fax as soon as confirmation of the delivery of the fax can be determined or when an expiration time has elapsed.

Abstract: A starting hole for milling in a surface of a workpiece by a CNC milling machine with a milling cutter mounted to a rotating spindle is created by milling a first hole at a first diameter to a first depth into the workpiece along the axis of the starting hole; and then successively milling a second hole at a second diameter to a second depth into the workpiece along the axis of the starting hole, wherein the second diameter is smaller than the first diameter. One or more additional holes may be successively milled to additional depths at successively smaller diameters.

Abstract: This disclosure is directed to systems and methods for the delivery and maintenance of faxes where the faxes may remain at a faxing system for a minimal amount of time. The faxing system may send a queued fax to a connector responsive to a request from the connector to pull or retrieve a fax. The connector is configured to send a release notification to the faxing system after the fax is received. The faxing system is configured to delete the queued fax as soon as confirmation of the delivery of the fax can be determined or when an expiration time has elapsed.

Abstract: This disclosure is directed to systems and methods for the delivery and maintenance of faxes where the faxes may remain at a faxing system for a minimal amount of time. The faxing system may send a queued fax to a connector responsive to a request from the connector to pull or retrieve a fax. The connector is configured to send a release notification to the faxing system after the fax is received. The faxing system is configured to delete the queued fax as soon as confirmation of the delivery of the fax can be determined or when an expiration time has elapsed.

Abstract: This disclosure is directed to systems and methods for the delivery and maintenance of faxes where the faxes may remain at a faxing system for a minimal amount of time. The faxing system may send a queued fax to a connector responsive to a request from the connector to pull or retrieve a fax. The connector is configured to send a release notification to the faxing system after the fax is received. The faxing system is configured to delete the queued fax as soon as confirmation of the delivery of the fax can be determined or when an expiration time has elapsed.

Abstract: A starting hole for milling in a surface of a workpiece by a CNC milling machine with a milling cutter mounted to a rotating spindle is created by milling a first hole at a first diameter to a first depth into the workpiece along the axis of the starting hole; and then successively milling a second hole at a second diameter to a second depth into the workpiece along the axis of the starting hole, wherein the second diameter is smaller than the first diameter. One or more additional holes may be successively milled to additional depths at successively smaller diameters.

Abstract: A method of generating control code for a CNC machine is described. The method includes the steps of: (1) generating in a computer a first plurality of coordinate values, xi, yi, zi, said first plurality of coordinate values representing a plurality of first connected line segments which surround a vertical axis, said first connected line segments gradually descending to a first predetermined depth, (2) generating in a computer a second plurality of coordinate values xj, yj, zj, said second coordinate values representing a plurality of second connected line segments which surround the vertical axis, said plurality of second connected line segments having a starting point at approximately the first predetermined depth, and gradually descending to a second predetermined depth greater than the first depth, and (3) converting the first and the second coordinate values to a code for controlling the CNC machine.

Abstract: This disclosure is directed to systems and methods for the delivery and maintenance of faxes where the faxes may remain at a faxing system for a minimal amount of time. The faxing system may send a queued fax to a connector responsive to a request from the connector to pull or retrieve a fax. The connector is configured to send a release notification to the faxing system after the fax is received. The faxing system is configured to delete the queued fax as soon as confirmation of the delivery of the fax can be determined or when an expiration time has elapsed.

Abstract: This disclosure is directed to systems and methods for the delivery and maintenance of faxes where the faxes may remain at a faxing system for a minimal amount of time. The faxing system may send a queued fax to a connector responsive to a request from the connector to pull or retrieve a fax. The connector is configured to send a release notification to the faxing system after the fax is received. The faxing system is configured to delete the queued fax as soon as confirmation of the delivery of the fax can be determined or when an expiration time has elapsed.

Abstract: A method for generating a tool path for milling a region of a workpiece is disclosed. The region has a first side meeting at its respective ends a first end of each of a second side and a third side. The method includes the steps of: (1) determining, using a computer, a radius of curvature and a center of each of a succession of circularly shaped tool passes, each successive tool pass advancing into the region from the first side of the region, wherein the radius of curvature and the center of each advancing tool pass is determined such that an engagement of the cutter following the tool path does not exceed a predetermined value of cutter engagement, and (2) generating instructions for controlling the milling cutter to mill the region in accordance with the generated tool path.

Abstract: A method is disclosed for generating a tool path for milling a region of a workpiece having first, second and third sides. The method includes: generating a first arc having a corresponding in-process material boundary intersecting the first side and which is tangent to the second side and to the third side; generating a succession of one or more second arcs, having a corresponding in-process material boundary which intersects the first side, is parallel to the first arc, and progresses by a corresponding first predetermined value from the first arc toward the first side until the in-process material boundary corresponding to one of the second arcs has a maximum distance from the first side less than the first predetermined value; and thereafter generating a succession of transition passes connecting each one of the second arcs end to end with the first arc to form the tool path.

Abstract: The present invention includes compositions and methods for modulating a regulator of IFNAR1. The invention includes inhibitors and activators of PERK, PTP1B, and/or PKD2 wherein inhibition, or activation, of at least one of PERK, PTP1B, and PKD2 modulates the stability of IFNAR1.

Abstract: A method is disclosed for generating a tool path for milling a region of a workpiece having first, second and third sides. The method includes: generating a first arc having a corresponding in-process material boundary intersecting the first side and which is tangent to the second side and to the third side; generating a succession of one or more second arcs, having a corresponding in-process material boundary which intersects the first side, is parallel to the first arc, and progresses by a corresponding first predetermined value from the first arc toward the first side until the in-process material boundary corresponding to one of the second arcs has a maximum distance from the first side less than the first predetermined value; and thereafter generating a succession of transition passes connecting each one of the second arcs end to end with the first arc to form the tool path.

Abstract: A method using a computer for generating a spiral-like tool path for milling a region of a workpiece is disclosed. The method includes the steps of: creating a family of concentric indexed circular arcs at each of two or more separate and distinct selected points within the region; determining parameters of a first set of blends to connect together the circular arcs of adjacent families of the circular arcs having an identical index to form a plurality of isoloops; determining parameters of a second set of blends for blending between adjacent isoloops to form the spiral-like tool path, and generating instructions for controlling the milling cutter in accordance with the generated tool path.