Patents by Inventor Alan F. Cook

Alan F. Cook has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Non-nucleotide phosphorus ester oligomers
    Patent number: 6008398
    Abstract: A phosphorus ester oligomer having the structure: wherein A can be the same or different in each monomeric unit and each is independently selected from the group consisting of oxygen, sulfur, lower alkyl, substituted or unsubstituted alkylamino, substituted or unsubstituted arylamino and aminoalkyl; B.sub.1 and B.sub.2 can be the same or different and each is independently selected from hydrogen, lower alkyl, a labeling group, a protecting group, a phosphoramidate or a phosphomonoester; R.sub.1 can be the same or different in each monomeric unit, and in at least one of the non-nucleotide monomeric units, R.sub.
    Type: Grant
    Filed: February 1, 1996
    Date of Patent: December 28, 1999
    Assignee: Genzyme Corporation
    Inventors: Robert Gerard Gentles, Alan F. Cook, Morris Jonathan Rudolph, Reza Fathi
  • Non-nucleotide phosphorus ester oligomers
    Patent number: 5919965
    Abstract: A phosphorus ester oligomer having the structure: ##STR1## wherein A can be the same or different in each monomeric unit and each is independently selected from the group consisting of oxygen, sulfur, lower alkyl, alkyl- or aryl-substituted amino and aminoalkyl; B.sub.1 and B.sub.2 can be the same or different and each is independently selected from hydrogen, lower alkyl, a labelling group, a protecting group, a phosphoramidate or a phosphomonoester; R.sub.1 can be the same or different in each monomeric unit, and in at least one of the non-nucleotide monomeric units, R.sub.
    Type: Grant
    Filed: January 18, 1995
    Date of Patent: July 6, 1999
    Assignee: Genzyme Corporation
    Inventors: Robert Gerard Gentles, Alan F. Cook, Morris Jonathan Rudolph, Reza Fathi
  • End labeled nucleotide probe
    Patent number: 5082830
    Abstract: An oligo- or polynucleotide having at least one biotin directly or indirectly attached to each of the 5' and 3' end nucleotides thereof and a nucleic acid hybridization assay system for use therewith. The biotins are optionally attached through linkage groups that do not interfere with hybridization. The biotins can further serve to attach a biotinylated polymer.
    Type: Grant
    Filed: February 26, 1988
    Date of Patent: January 21, 1992
    Assignee: Enzo Biochem, Inc.
    Inventors: Christine L. Brakel, Alan F. Cook, Edmund Vuocolo
  • Non-radioactive carbodiimide precursor to nucleic acid probes
    Patent number: 4895955
    Abstract: This invention relates to carbodiimide compounds of the formula:Z--L--W--N.dbd.C.dbd.N--R.sub.1wherein Z is a signalling moiety or a protecting group; L is a divalent linking group; W is an alkylene group having up to 24 carbon atoms which can be substituted or interrupted by a water solubility enhancing group or cleavable S--S group; and R.sub.1 is an alkyl group having up to 18 carbon atoms. These compounds are useful in the nonradioactive labelling of nucleic acid probes, and methods employing same.
    Type: Grant
    Filed: May 27, 1988
    Date of Patent: January 23, 1990
    Assignees: Lifecodes Corporation, Quantum Chemical Corporation, Trustees of Columbia University
    Inventors: John P. Ford, Charles W. Blewett, Michael D. Sublett, Bernard F. Erlanger, Alan F. Cook
  • Process to produce 1-methyl isoguanosine
    Patent number: 4148993
    Abstract: A process to produce 1-methyl isoquanosine, a compound of the formula ##STR1## is disclosed. Also disclosed is a novel intermediate in said process. The 1-methyl isoguanosine has been found to have pharmacological activity, e.g. anti-inflammatory activity and muscle relaxant activity.
    Type: Grant
    Filed: February 10, 1978
    Date of Patent: April 10, 1979
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Alan F. Cook, Ronald J. Quinn