Abstract: A system is described that is capable of operating as an energy conversion system that functions as a fuel cell and generates electrical current from a fuel or fuels, or as a reactor for conversion of starter materials into more complex molecules through ion-ion and ion-molecules and which may preferably be adapted to operate as a gas to liquid (GTL) process. The system ionises at least one fuel or starter material and manipulates, selects and transports ions for reaction by means of suitable electrostatic or electrodynamic ion guides, filters or drift tubes. The system of the present application replaces the electrolyte, catalyst and/or membrane found in classic fuel cells or GTL processes with an electrostatic or electrodynamic ion manipulation region such as an ion guide, analyser, drift tube or filter.

Abstract: A system is described that is capable of operating as an energy conversion system that functions as a fuel cell and generates electrical current from a fuel or fuels, or as a reactor for conversion of starter materials into more complex molecules through ion-ion and ion-molecules and which may preferably be adapted to operate as a gas to liquid (GTL) process. The system ionises at least one fuel or starter material and manipulates, selects and transports ions for reaction by means of suitable electrostatic or electrodynamic ion guides, filters or drift tubes. The system of the present application replaces the electrolyte, catalyst and/or membrane found in classic fuel cells or GTL processes with an electrostatic or electrodynamic ion manipulation region such as an ion guide, analyser, drift tube or filter.

Abstract: Methods for treating a human subject who has X-linked Retinitis Pigmentosa (XLRP) or another clinically-defined ophthalmological condition due to a loss-of-function mutation in the gene encoding the retinitis pigmentosa GTPase regulator (RPGR) protein, the method comprising administering to the subject a nucleic acid comprising an adeno-associated viral vector comprising an abbreviated human RPGR cDNA.

Abstract: A system is described that is capable of operating as an energy conversion system that functions as a fuel cell and generates electrical current from a fuel or fuels, or as a reactor for conversion of starter materials into more complex molecules through ion-ion and ion-molecules and which may preferably be adapted to operate as a gas to liquid (GTL) process. The system ionises at least one fuel or starter material and manipulates, selects and transports ions for reaction by means of suitable electrostatic or electrodynamic ion guides, filters or drift tubes. The system of the present application replaces the electrolyte, catalyst and/or membrane found in classic fuel cells or GTL processes with an electrostatic or electrodynamic ion manipulation region such as an ion guide, analyser, drift tube or filter.

Abstract: Methods for treating a human subject who has X-linked Retinitis Pigmentosa (XLRP) or another clinically-defined ophthalmological condition due to a loss-of-function mutation in the gene encoding the retinitis pigmentosa GTPase regulator (RPGR) protein, the method comprising administering to the subject a nucleic acid comprising an adeno-associated viral vector comprising an abbreviated human RPGR cDNA.

Abstract: Methods for treating a human subject who has X-linked Retinitis Pigmentosa (XLRP) or another clinically-defined ophthalmological condition due to a loss-of-function mutation in the gene encoding the retinitis pigmentosa GTPase regulator (RPGR) protein, the method comprising administering to the subject a nucleic acid comprising an adeno-associated viral vector comprising an abbreviated human RPGR cDNA.

Abstract: A system is described that is capable of operating as an energy conversion system that functions as a fuel cell and generates electrical current from a fuel or fuels, or as a reactor for conversion of starter materials into more complex molecules through ion-ion and ion-molecules and which may preferably be adapted to operate as a gas to liquid (GTL) process. The system ionises at least one fuel or starter material and manipulates, selects and transports ions for reaction by means of suitable electrostatic or electrodynamic ion guides, filters or drift tubes. The system of the present application replaces the electrolyte, catalyst and/or membrane found in classic fuel cells or GTL processes with an electrostatic or electrodynamic ion manipulation region such as an ion guide, analyser, drift tube or filter.

Abstract: Methods for treating a human subject who has X-linked Retinitis Pigmentosa (XLRP) or another clinically-defined ophthalmological condition due to a loss-of-function mutation in the gene encoding the retinitis pigmentosa GTPase regulator (RPGR) protein, the method comprising administering to the subject a nucleic acid comprising an adeno-associated viral vector comprising an abbreviated human RPGR cDNA.

Abstract: A portable analytical system for the rapid on-site analysis of fluids, and a method for using this system at the well-site for the analysis of samples extracted from drilling fluids is described. The portable analytical solution may be deployed at the well-site and used to perform detailed real-time analysis of formation fluids and extracts of rock cuttings. The method described could be used during hydrocarbon exploration and production to determine whether the drill stem has passed through a hydrocarbon-bearing region, or rocks that are capable of functioning as an oil reservoir or that may have been a source rock, or that may have come into contact with oil, or that may contain oil at present.

Abstract: This invention describes an analytical system where a kinetic impact ionization source is combined with an RF-only ion guide to form a mass spectrometer system for analysis of the elemental and chemical composition of exoatmospheric particles. The kinetic impact ionization source may be used to transform a flux of particle debris into a beam of ions for analysis by a mass analyzer.

Abstract: This invention describes a vacuum interface for a mass spectrometer system formed from a diverging nozzle. The vacuum interface may be used to transfer a beam of ions from an atmospheric pressure ionization source into a vacuum chamber for analysis by a mass analyser.

Abstract: This invention describes a multi-stage pre-concentrator device for use with a detector system. One pre-concentrator stage is detachable and may be used to collect sample remotely from the detection system. The detachable pre-concentrator stage mates with the detector system and can transfer its desorbed sample to another pre-concentrator stage which also incorporates the functions of a sample loop serving as an injection volume to the separation column of an analytical instrument. In one embodiment the fixed pre-concentrator stage serves as a sample loop that preferably integrates suitable valves with sorbent materials onto the same structure to minimise dead volume, maximise sensitivity, improving column loading efficiency, reducing duty cycles and minimising detection system response time.

Abstract: A device and method is described for direct analysis of solvents used to chemically bind with CO2 present in flue gases, and for the monitoring of large-scale CO2 solvent-capture reaction to improve process efficiency, thereby reducing the cost of CO2 capture.

Abstract: Microengineered stacked ring electrode assemblies capable of acting as either RF or DC ion guides in an ion optical system, and method of fabricating same are described. The electrodes are fabricated using planar processing as sets of grooved, proud features formed in a layer of material lying on an insulating substrate. Two such structures are then stacked together to form a set of diaphragm electrodes with closed pupils. Arrangements for fabrication by patterning, etching and bonding are described, together with methods for tapering the electrode pupils or otherwise varying the ion path.

Abstract: A sample collection and detection system is described. The detection system provides a sample chamber fluidly coupled to a secondary ionisation source to allow the introduction of vapour generated from the sample into an ion path generated from the secondary ionisation source. The secondary ionisation source is a secondary electrospray ionisation (SESI) source, and is usefully employed in dust analysis.

Abstract: This invention describes an analytical system where a kinetic impact ionisation source is combined with an RF—only ion guide to form a mass spectrometer system for analysis of the elemental and chemical composition of exoatmospheric particles. The kinetic impact ionisation source may be used to transform a flux of particle debris into a beam of ions for analysis by a mass analyzer.

Abstract: This invention describes a microengineered SFC system for rapidly and efficiently separating the constituents of a complex mixture. The SFC system includes a microchannel that is microfabricated from a suitable substrate so that it forms a chromatographic column for separation of chemicals. The surface area of the microchannel of the column is sufficiently small as to permit use of miniature and relatively inexpensive pumps, and the thermal mass of the microengineered column is sufficiently low as to permit rapid temperature cycling using a miniature, low power and inexpensive heating element. At least a portion of this microchannel is packed with suitable sorbent materials or includes surfaces which are suitably coated with sorbent, or both, so as to retain and elute analyte under certain conditions. As a result analyte passing within this microchannel undergoes chromatographic separation.

Abstract: A portable analytical system for the rapid on-site analysis of fluids, and a method for using this system at the well-site for the analysis of samples extracted from drilling fluids is described. The portable analytical solution may be deployed at the well-site and used to perform detailed real-time analysis of formation fluids and extracts of rock cuttings. The method described could be used during hydrocarbon exploration and production to determine whether the drill stem has passed through a hydrocarbon-bearing region, or rocks that are capable of functioning as an oil reservoir or that may have been a source rock, or that may have come into contact with oil, or that may contain oil at present.

Abstract: This invention describes an electrode structure formed from a plurality of individual electrodes, the individual electrodes being provided on separate submounts, the submounts being coupled to one another using kinematic ball mounts. Such a structure may be configured as a RF ion guide, mass filter or ion trap.

Abstract: A portable mass spectrometer system is described. The system includes a mass spectrometer device incorporated within an evacuated chamber. The chamber includes a permeable membrane located between the mass spectrometer device and an entrance port to the chamber. Located between the membrane and the entrance port is a valve. The valve is provided in an normally closed state and has an open state, such that, in use, the adoption of the open state allows the flow of the sample into the chamber through the membrane and into contact with the spectrometer device.