Patents by Inventor Alan Flake

Alan Flake has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 12268802
    Abstract: Disclosed are devices and methods directed to oxygenators for use in extracorporeal circuits for supporting a fetus. An oxygenator for use with an extracorporeal circuit includes a housing defining a cavity therein and a gas exchanger disposed within the interior cavity. The cavity is configured to receive blood a fetus. The gas exchanger is configured to receive a sweep gas and further configured to contact the blood within the cavity, such that at least oxygen gas and carbon dioxide gas is permitted to diffuse between the blood and the gas exchanger.
    Type: Grant
    Filed: April 8, 2020
    Date of Patent: April 8, 2025
    Assignee: The Children's Hospital of Philadelphia
    Inventors: Marcus Graeme Davey, Alan Flake
  • Publication number: 20240390205
    Abstract: A system configured to support growth and development of a premature fetus is disclosed. Specifically, a method and apparatus configured to provide extracorporeal support for premature fetuses is disclosed.
    Type: Application
    Filed: July 31, 2024
    Publication date: November 28, 2024
    Inventors: Alan FLAKE, Marcus Davey
  • Patent number: 12083048
    Abstract: A system configured to support growth and development of a premature fetus is disclosed. Specifically, a method and apparatus configured to provide extracorporeal support for premature fetuses is disclosed.
    Type: Grant
    Filed: February 10, 2021
    Date of Patent: September 10, 2024
    Assignee: The Children's Hospital of Philadelphia
    Inventors: Alan Flake, Marcus Davey
  • Publication number: 20230310246
    Abstract: Extracorporeal membrane oxygenation systems and methods of use are disclosed. Several publications and patent documents are cited throughout the specification in order to describe the state of the art to which this invention pertains. Full citations of these references can be found throughout the specification. Each of these citations is incorporated herein by reference as though set forth in full.
    Type: Application
    Filed: June 7, 2023
    Publication date: October 5, 2023
    Inventors: Alan Flake, Emily Partridge, Marcus Davey
  • Patent number: 11707394
    Abstract: Extracorporeal membrane oxygenation systems and methods of use are disclosed. Several publications and patent documents are cited throughout the specification in order to describe the state of the art to which this invention pertains. Full citations of these references can be found throughout the specification. Each of these citations is incorporated herein by reference as though set forth in full.
    Type: Grant
    Filed: November 10, 2020
    Date of Patent: July 25, 2023
    Assignee: The Children's Hospital of Philadelphia
    Inventors: Alan Flake, Emily Partridge, Marcus Graeme Davey
  • Patent number: 11471351
    Abstract: A system configured to enclose a premature fetus within an extracorporeal environment to promote growth of the fetus and increase viability of the fetus. The system includes a chamber having an interior space configured to enclose the fetus, a first fluid circuit that delivers sterile fluid to the chamber, and a second fluid system that transfers oxygen to the fetus. The system chamber includes a stop mechanism including a clamp and an actuator, the clamp positioned in the interior space, the actuator coupled to the clamp such that movement of the actuator moves the clamp, and the actuator positioned at least partially outside the interior space.
    Type: Grant
    Filed: December 13, 2017
    Date of Patent: October 18, 2022
    Assignee: The Children's Hospital of Philadelphia
    Inventors: Alan Flake, Marcus Davey
  • Publication number: 20220193318
    Abstract: Disclosed are devices and methods directed to oxygenators for use in extracorporeal circuits for supporting a fetus. An oxygenator for use with an extracorporeal circuit includes a housing defining a cavity therein and a gas exchanger disposed within the interior cavity. The cavity is configured to receive blood a fetus. The gas exchanger is configured to receive a sweep gas and further configured to contact the blood within the cavity, such that at least oxygen gas and carbon dioxide gas is permitted to diffuse between the blood and the gas exchanger.
    Type: Application
    Filed: April 8, 2020
    Publication date: June 23, 2022
    Inventors: Marcus Graeme DAVEY, Alan FLAKE
  • Publication number: 20210161744
    Abstract: A system configured to support growth and development of a premature fetus is disclosed. Specifically, a method and apparatus configured to provide extracorporeal support for premature fetuses is disclosed.
    Type: Application
    Filed: February 10, 2021
    Publication date: June 3, 2021
    Inventors: Alan Flake, Marcus Davey
  • Patent number: 10945903
    Abstract: A system configured to support growth and development of a premature fetus is disclosed. Specifically, a method and apparatus configured to provide extracorporeal support for premature fetuses is disclosed.
    Type: Grant
    Filed: April 14, 2020
    Date of Patent: March 16, 2021
    Assignee: The Children's Hospital of Philadelphia
    Inventors: Alan Flake, Marcus Davey
  • Publication number: 20210052453
    Abstract: Extracorporeal membrane oxygenation systems and methods of use are disclosed. Several publications and patent documents are cited throughout the specification in order to describe the state of the art to which this invention pertains. Full citations of these references can be found throughout the specification. Each of these citations is incorporated herein by reference as though set forth in full.
    Type: Application
    Filed: November 10, 2020
    Publication date: February 25, 2021
    Inventors: Alan Flake, Emily Partridge, Marcus Graeme Davey
  • Patent number: 10864131
    Abstract: Extracorporeal membrane oxygenation systems and methods of use are disclosed. Several publications and patent documents are cited throughout the specification in order to describe the state of the art to which this invention pertains. Full citations of these references can be found throughout the specification. Each of these citations is incorporated herein by reference as though set forth in full.
    Type: Grant
    Filed: August 21, 2018
    Date of Patent: December 15, 2020
    Inventors: Alan Flake, Emily Partridge, Marcus Davey
  • Publication number: 20200268582
    Abstract: A system configured to support growth and development of a premature fetus is disclosed. Specifically, a method and apparatus configured to provide extracorporeal support for premature fetuses is disclosed.
    Type: Application
    Filed: April 14, 2020
    Publication date: August 27, 2020
    Inventors: Alan Flake, Marcus Davey
  • Patent number: 10751238
    Abstract: A system configured to support growth and development of a premature fetus is disclosed. Specifically, a method and apparatus configured to provide extracorporeal support for premature fetuses is disclosed.
    Type: Grant
    Filed: June 17, 2016
    Date of Patent: August 25, 2020
    Assignee: The Children's Hospital of Philadelphia
    Inventors: Alan Flake, Marcus Davey
  • Publication number: 20190380900
    Abstract: A system configured to enclose a premature fetus within an extracorporeal environment to promote growth of the fetus and increase viability of the fetus. The system includes a chamber having an interior space configured to enclose the fetus, a first fluid circuit that delivers sterile fluid to the chamber, and a second fluid system that transfers oxygen to the fetus. The system chamber includes a stop mechanism including a clamp and an actuator, the clamp positioned in the interior space, the actuator coupled to the clamp such that movement of the actuator moves the clamp, and the actuator positioned at least partially outside the interior space.
    Type: Application
    Filed: December 13, 2017
    Publication date: December 19, 2019
    Inventors: Alan FLAKE, Marcus DAVEY
  • Publication number: 20190008712
    Abstract: Extracorporeal membrane oxygenation systems and methods of use are disclosed. Several publications and patent documents are cited throughout the specification in order to describe the state of the art to which this invention pertains. Full citations of these references can be found throughout the specification. Each of these citations is incorporated herein by reference as though set forth in full.
    Type: Application
    Filed: August 21, 2018
    Publication date: January 10, 2019
    Inventors: Alan Flake, Emily Partridge, Marcus Davey
  • Patent number: 10085907
    Abstract: Extracorporeal membrane oxygenation systems and methods of use are disclosed. Several publications and patent documents are cited throughout the specification in order to describe the state of the art to which this invention pertains. Full citations of these references can be found throughout the specification. Each of these citations is incorporated herein by reference as though set forth in full.
    Type: Grant
    Filed: March 17, 2014
    Date of Patent: October 2, 2018
    Assignee: The Children's Hospital of Philadelphia
    Inventors: Alan Flake, Emily Partridge, Marcus Davey
  • Publication number: 20180168901
    Abstract: A system configured to support growth and development of a premature fetus is disclosed. Specifically, a method and apparatus configured to provide extracorporeal support for premature fetuses is disclosed.
    Type: Application
    Filed: June 17, 2016
    Publication date: June 21, 2018
    Inventors: Alan FLAKE, Marcus DAVEY
  • Publication number: 20160022524
    Abstract: Extracorporeal membrane oxygenation systems and methods of use are disclosed. Several publications and patent documents are cited throughout the specification in order to describe the state of the art to which this invention pertains. Full citations of these references can be found throughout the specification. Each of these citations is incorporated herein by reference as though set forth in full.
    Type: Application
    Filed: March 17, 2014
    Publication date: January 28, 2016
    Inventors: Alan Flake, Emily Partridge, Marcus Davey
  • Publication number: 20060134224
    Abstract: An engineered bone marrow composition, preferably comprising bone marrow cells, pulverized bone, and type 1 collagen, can be transplanted into the portal system of a patient. The engineered bone marrow provides a microenvironment, for engraftment of hematopoietic stem cells, that increases levels of chimerism while decreasing or eliminating failure of engraftment.
    Type: Application
    Filed: December 28, 2005
    Publication date: June 22, 2006
    Inventors: Alan Flake, Alexander Krupnick