Patents by Inventor Alan Florjancic

Alan Florjancic has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • NOVEL COMPOUNDS AS CANNABINOID RECEPTOR LIGANDS AND USES THEREOF
    Publication number: 20080064699
    Abstract: The present invention relates to compounds of formula (I), or pharmaceutically acceptable salts, prodrugs, salts of prodrugs, or combinations thereof, wherein R1, R2, R3, R4, and L2, are defined in the specification, compositions comprising such compounds, and methods of treating conditions and disorders using such compounds and compositions.
    Type: Application
    Filed: May 31, 2007
    Publication date: March 13, 2008
    Inventors: Alan Florjancic, Michael Dart, Keith Ryther, Arturo Perez-Medrano, William Carroll, Meena Patel, Karin Tietje, Tongmei Li, Teodozyj Kolasa, Megan Gallagher, Sridhar Peddi, Jennifer Frost, Derek Nelson
  • NOVEL COMPOUNDS AS CANNABINOID RECEPTOR LIGANDS AND USES THEREOF
    Publication number: 20080058335
    Abstract: The present invention relates to compounds of formula (I), or pharmaceutical salts, prodrugs, salts of prodrugs, or combinations thereof, wherein R1, R2, R3, and L1 are defined in the specfication, compositions comprising such compounds, and methods of treating conditions and disorders using such compounds and compositions. The present invention also relates to compounds of formula (II), or pharmaceutical salts, prodrugs, salts of prodrugs, or combinations thereof, wherein R1a, R2a and (Rx)n are as defined in the specification, compositions comprising such compounds, and methods of treating conditions and disorders using such compounds and compositions.
    Type: Application
    Filed: May 30, 2007
    Publication date: March 6, 2008
    Inventors: Alan Florjancic, Michael Dart, Keith Ryther, Arturo Perez-Medrano, William Carroll, Meena Patel, Karin Tietje, Tongmei Li, Teodozyj Kolasa, Megan Gallagher, Sridhar Peddi, Jennifer Frost, Derek Nelson
  • Cyanoamidine P2X7 Antagonists for the Treatment of Pain
    Publication number: 20070232686
    Abstract: Novel cyanoamidines compounds of formula (I) and (II) and their derivatives wherein R1-R12 are as defined in the specification act as antagonists of the P2X7 receptor. These compounds are particularly useful in the treatment of pain, inflammation and neurodegeneration states.
    Type: Application
    Filed: May 18, 2007
    Publication date: October 4, 2007
    Inventors: William Carroll, Arturo Perez-Medrano, Sridhar Peddi, Alan Florjancic
  • P2X7 receptor antagonists and methods of use
    Publication number: 20070105842
    Abstract: The invention is directed to compounds that are P2X7 antagonist and have the formula (I) or (II) or a pharmaceutically acceptable salt, prodrug, salt of a prodrug or a combination thereof, wherein R1, R2, and R3 are defined in the specification. The invention is also directed to a method of selectively inhibiting P2X7 activity comprising administering to a patient in need of such treatment a therapeutically effective amount of a compound of formula (III), (IV) or (V) wherein R6, R7, R8, R9, R10, and R11 are defined in the specification.
    Type: Application
    Filed: November 6, 2006
    Publication date: May 10, 2007
    Inventors: William Carroll, Alan Florjancic, Arturo Perez-Medrano, Sridhar Peddi
  • Amino-tetrazoles analogues and methods of use
    Publication number: 20070049584
    Abstract: A compound having Formula (I) or Formula (II) is disclosed as an P2X7 antagonist, wherein A, B, C, Y, Y, Z, m, v, R1, R2, R3, R4, and R5, are as defined in the description. Methods and compositions for treating disease or condition modulated by P2X7 are also disclosed.
    Type: Application
    Filed: April 29, 2005
    Publication date: March 1, 2007
    Inventors: William Carroll, Arturo Perez-Medrano, Alan Florjancic, Derek Nelson, Sridhar Peddi, Tongmei Li, Eric Bunnelle, Gavin Hirst, Biquin Li
  • Amino-tetrazole analogues and methods of use
    Publication number: 20060052374
    Abstract: A compound having Formula (I) or Formula (II) is disclosed as an P2X7 antagonist, wherein A, B, C, Y, Y, Z, m, v, R1, R2, R3, R4, and R5, are as defined in the description. Methods and compositions for treating disease or condition modulated by P2X7 are also disclosed.
    Type: Application
    Filed: September 7, 2005
    Publication date: March 9, 2006
    Inventors: William Carroll, Arturo Perez-Medrano, Alan Florjancic, Derek Nelson, Sridhar Peddi, Tongmei Li, Eric Bunnelle, Gavin Hirst, Biquin Li
  • Cyanoamidine P2X7 antagonists for the treatment of pain
    Publication number: 20060025614
    Abstract: Novel cyanoamidines compounds of formula (I) and (II) and their derivatives wherein R1-R12 are as defined in the specification act as antagonists of the P2X7 receptor. These compounds are particularly useful in the treatment of pain, inflammation and neurodegeneration states.
    Type: Application
    Filed: August 2, 2004
    Publication date: February 2, 2006
    Inventors: William Carroll, Arturo Perez-Medrano, Sridhar Peddi, Alan Florjancic
  • Biphenyl hydroxamate inhibitors of matrix metalloproteinases
    Patent number: 5665777
    Abstract: Compounds of formula ##STR1## or a pharmaceutically acceptable salt thereof inhibit matrix metalloproteinases and TNF.alpha. secretion and are useful in the treatment of inflammatory disease states. Also disclosed are matrix metalloproteinases and TNF.alpha. secretion inhibiting compositions and a method for inhibiting matrix metalloproteinases and TNF.alpha. secretion.
    Type: Grant
    Filed: November 14, 1995
    Date of Patent: September 9, 1997
    Assignee: Abbott Laboratories
    Inventors: Stephen W. Fesik, James B. Summers, Jr., Steven K. Davidsen, George S. Sheppard, Douglas H. Steinman, George M. Carrera, Jr., Alan Florjancic, James H. Holms