Patents by Inventor Alan Frankel
Alan Frankel has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 10154992Abstract: Provided herein, inter alia, are methods and compounds for treating an HIV infection.Type: GrantFiled: July 12, 2017Date of Patent: December 18, 2018Assignees: The Regents of the University of California, Advanced Genetic Systems, Inc.Inventors: Robert Nakamura, Mark Burlingame, Alan Frankel, Adam Renslo
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Publication number: 20180015077Abstract: Provided herein, inter alia, are methods and compounds for treating an HIV infection.Type: ApplicationFiled: July 12, 2017Publication date: January 18, 2018Inventors: Robert Nakamura, Mark Burlingame, Alan Frankel, Adam Renslo
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Patent number: 8148129Abstract: The present invention provides methods and compositions for regulating gene expression using transcription factors linked to proteins that localize to the transcriptional machinery.Type: GrantFiled: June 20, 2007Date of Patent: April 3, 2012Assignee: The Regents of the University of CaliforniaInventors: Alan Frankel, Robert Nakamura, Chandreyee Das, Ivan D'Orso, Jocelyn Grunwell
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Patent number: 7996223Abstract: A system and method may be disclosed for facilitating the conversion of dictation into usable and formatted documents by providing a method of post processing speech recognition output. In particular, the post processing system may be configured to implement rewrite rules and process raw speech recognition output or other raw data according to those rewrite rules. The application of the rewrite rules may format and/or normalize the raw speech recognition output into formatted or finalized documents and reports. The system may thereby reduce or eliminate the need for post processing by transcriptionists or dictation authors.Type: GrantFiled: September 29, 2004Date of Patent: August 9, 2011Assignee: Dictaphone CorporationInventors: Alan Frankel, Ana Santisteban
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Patent number: 7937263Abstract: The present invention pertains to a system and method for the tokenization of text. The featurizer may be configured to receive input text and convert the input text into tokens. According to one aspect of the invention, the tokens may include only one type of character, the characters selected from the group consisting of letters, numbers, and punctuation. The tokenizer may also include a classifier. The classifier may be configured to receive the tokens from the featurizer. Furthermore, the classifier may be configured to analyze the tokens received from the featurizer to determine if the tokens may be input into a predetermined classification model using a preclassifier. If one of the tokens passes the preclassifier, then the token is classified using the predetermined classification model. Additionally, according to a first aspect of the invention, the tokenizer may also include a finalizer. The finalizer may be configured to receive the tokens and may be configured to produce a final output.Type: GrantFiled: December 1, 2004Date of Patent: May 3, 2011Assignee: Dictaphone CorporationInventors: Jill Carrier, Alwin B. Carus, William F. Cote, John Dowd, Kathryn Del La Femina, Alan Frankel, Wensheng(Vincent) Han, Larissa Lapshina, Bernardo Rechea, Ana Santisteban, Amy J. Uhrbach
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Patent number: 7860717Abstract: A system and method may be disclosed for facilitating the site-specific customization of automated speech recognition systems by providing a customization client for site-specific individuals to update and modify language model input files and post processor input files. In customizing the input files, the customization client may provide a graphical user interface for facilitating the inclusion of words specific to a particular site. The customization client may also be configured to provide the user with a series of formatting rules for controlling the appearance and format of a document transcribed by an automated speech recognition system.Type: GrantFiled: September 27, 2004Date of Patent: December 28, 2010Assignee: Dictaphone CorporationInventors: Amy J. Urhbach, Alan Frankel, Jill Carrier, Ana Santisteban, William F. Cote
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Publication number: 20080096813Abstract: The present invention provides methods and compositions for regulating gene expression using transcription factors linked to proteins that localize to the transcriptional machinery.Type: ApplicationFiled: June 20, 2007Publication date: April 24, 2008Applicants: REGENTS OF THE UNIVERSITY OF CALIFORNIA Office of Technology Transfer, Advanced Genetic Systems, IncInventors: Alan Frankel, Robert Nakamura, Chandreyee Das, Ivan D'Orso, Jocelyn Grunwell
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Publication number: 20060116862Abstract: The present invention pertains to a system and method for the tokenization of text. The featurizer may be configured to receive input text and convert the input text into tokens. According to one aspect of the invention, the tokens may include only one type of character, the characters selected from the group consisting of letters, numbers, and punctuation. The tokenizer may also include a classifier. The classifier may be configured to receive the tokens from the featurizer. Furthermore, the classifier may be configured to analyze the tokens received from the featurizer to determine if the tokens may be input into a predetermined classification model using a preclassifier. If one of the tokens passes the preclassifier, then the token is classified using the predetermined classification model. Additionally, according to a first aspect of the invention, the tokenizer may also include a finalizer. The finalizer may be configured to receive the tokens and may be configured to produce a final output.Type: ApplicationFiled: December 1, 2004Publication date: June 1, 2006Applicant: Dictaphone CorporationInventors: Jill Carrier, Alwin Carus, William Cote, John Dowd, Kathryn Femina, Alan Frankel, Wensheng Han, Larissa Lapshina, Bernardo Rechea, Ana Santisteban, Amy Uhrbach
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Publication number: 20050114122Abstract: 5 A system and method may be disclosed for facilitating the site-specific customization of automated speech recognition systems by providing a customization client for site-specific individuals to update and modify language model input files and post processor input files. In customizing the input files, the customization client may provide a graphical user interface for facilitating the inclusion of words specific to a particular site. The customization client may also be configured to provide the user with a series of formatting rules for controlling the appearance and format of a document transcribed by an automated speech recognition system.Type: ApplicationFiled: September 27, 2004Publication date: May 26, 2005Applicant: Dictaphone CorporationInventors: Amy Uhrbach, Alan Frankel, Jill Carrier, Ana Santisteban, William Cote
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Publication number: 20050108010Abstract: A system and method may be disclosed for facilitating the conversion of dictation into usable and formatted documents by providing a method of post processing speech recognition output. In particular, the post processing system may be configured to implement rewrite rules and process raw speech recognition output or other raw data according to those rewrite rules. The application of the rewrite rules may format and/or normalize the raw speech recognition output into formatted or finalized documents and reports. The system may thereby reduce or eliminate the need for post processing by transcriptionists or dictation authors.Type: ApplicationFiled: September 29, 2004Publication date: May 19, 2005Applicant: Dictaphone CorporationInventors: Alan Frankel, Ana Santisteban
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Patent number: 6316003Abstract: This invention relates to delivery of biologically active cargo molecules, such as polypeptides and nucleic acids, into the cytoplasm and nuclei of cells in vitro and in vivo. Intracellular delivery of cargo molecules according to this invention is accomplished by the use of novel transport polypeptides which include HIV tat protein or one or more portions thereof, and which are covalently attached to cargo molecules. The transport polypeptides in preferred embodiments of this invention are characterized by the presence of the tat basic region (amino acids 49-57), the absence of the tat cysteine-rich region (amino acids 22-36) and the absence of the tat exon 2-encoded carboxy-terminal domain (amino acids 73-86) of the naturally-occurring tat protein. By virtue of the absence of the cysteine-rich region, the preferred transport polypeptides of this invention solve the potential problems of spurious trans-activation and disulfide aggregation.Type: GrantFiled: April 28, 1994Date of Patent: November 13, 2001Assignees: Whitehead Institute for Biomedical Research, Johns Hopkins Univ. School of Medicine, Biogen, Inc.Inventors: Alan Frankel, Carl Pabo, James G. Barsoum, Stephen E. Fawell, R. Blake Pepinsky
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Patent number: 5834184Abstract: The invention provides methods and kits suitable for large-scale in vivo screening of polypeptides for specific binding affinity to a selected RNA recognition sequence. Polypeptide(s) are screened as fusion proteins with a polypeptide having antitermination activity. Polypeptides having binding activity are identified by their capacity to activate transcription of a reporter gene via binding of the polypeptide being screened to the selected RNA recognition sequence. The invention also provides methods of screening RNA molecules for binding to a selected polypeptide.Type: GrantFiled: May 17, 1995Date of Patent: November 10, 1998Inventors: Kazuo Harada, Shelley S. Martin, Alan Frankel
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Patent number: 5804604Abstract: This invention relates to delivery of biologically active cargo molecules, such as polypeptides and nucleic acids, into the cytoplasm and nuclei of cells in vitro and in vivo. Intracellular delivery of cargo molecules according to this invention is accomplished by the use of novel transport polypeptides which comprise HIV tat protein or one or more portions thereof, and which are covalently attached to cargo molecules. The transport polypeptides in preferred embodiments of this invention are characterized by the presence of the tat basic region (amino acids 49-57), the absence of the tat cysteine-rich region (amino acids 22-36) and the absence of the tat exon 2-encoded carboxy-terminal domain (amino acids 73-86) of the naturally-occurring tat protein. By virtue of the absence of the cysteine-rich region, the preferred transport polypeptides of this invention solve the potential problems of spurious trans-activation and disulfide aggregation.Type: GrantFiled: May 25, 1995Date of Patent: September 8, 1998Assignee: Biogen, Inc.Inventors: Alan Frankel, Carl Pabo, James G. Barsoum, Stephen E. Fawell, R. Blake Pepinsky
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Patent number: 5747641Abstract: This invention relates to delivery of biologically active cargo molecules, such as polypeptides and nucleic acids, into the cytoplasm and nuclei of cells in vitro and in vivo. Intracellular delivery of cargo molecules according to this invention is accomplished by the use of novel transport polypeptides which comprise HIV tat protein or one or more portions thereof, and which are covalently attached to cargo molecules. The transport polypeptides in preferred embodiments of this invention are characterized by the presence of the tat basic region (amino acids 49-57), the absence of the tat cysteine-rich region (amino acids 22-36) and the absence of the tat exon 2-encoded carboxy-terminal domain (amino acids 73-86) of the naturally-occurring tat protein. By virtue of the absence of the cysteine-rich region, the preferred transport polypeptides of this invention solve the potential problems of spurious trans-activation and disulfide aggregation.Type: GrantFiled: May 25, 1995Date of Patent: May 5, 1998Inventors: Alan Frankel, Carl Pabo, James G. Barsoum, Stephen E. Fawell, R. Blake Pepinsky
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Patent number: 5674980Abstract: This invention relates to delivery of biologically active cargo molecules, such as polypeptides and nucleic acids, into the cytoplasm and nuclei of cells in vitro and in vivo. Intracellular delivery of cargo molecules according to this invention is accomplished by the use of novel transport polypeptides which comprise HIV tat protein or one or more portions thereof, and which are covalently attached to cargo molecules. The transport polypeptides in preferred embodiments of this invention are characterized by the presence of the tat basic region (amino acids 49-57), the absence of the tat cysteine-rich region (amino acids 22-36) and the absence of the tat exon 2-encoded carboxy-terminal domain (amino acids 73-86) of the naturally-occurring tat protein. By virtue of the absence of the cysteine-rich region, the preferred transport polypeptides of this invention solve the potential problems of spurious trans-activation and disulfide aggregation.Type: GrantFiled: May 25, 1995Date of Patent: October 7, 1997Inventors: Alan Frankel, Carl Pabo, James G. Barsoum, Stephen E. Fawell, R. Blake Pepinsky
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Patent number: 5670617Abstract: This invention relates to delivery of biologically active cargo molecules, such as polypeptides and nucleic acids, into the cytoplasm and nuclei of cells in vitro and in vivo. Intracellular delivery of cargo molecules according to this invention is accomplished by the use of novel transport polypeptides which comprise HIV tat protein or one or more portions thereof, and which are covalently attached to cargo molecules. The transport polypeptides in preferred embodiments of this invention are characterized by the presence of the tat basic region (amino acids 49-57), the absence of the tat cysteine-rich region (amino acids 22-36) and the absence of the tat exon 2-encoded carboxy-terminal domain (amino acids 73-86) of the naturally-occurring tat protein. By virtue of the absence of the cysteine-rich region, the preferred transport polypeptides of this invention solve the potential problems of spurious trans-activation and disulfide aggregation.Type: GrantFiled: May 25, 1995Date of Patent: September 23, 1997Inventors: Alan Frankel, Carl Pabo, James G. Barsoum, Stephen E. Fawell, R. Blake Pepinsky
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Patent number: 5654398Abstract: Compositions and methods for identifying compositions which inhibit binding of the Rev protein to the Rev-responsive element in cells infected by HIV-1 are provided. The compositions display or mimic the electronic configuration of a binding domain within the native Rev protein, but are free from those portions responsible for REV activity and are preferably modified to display enhanced binding affinity to the RRE. Screening methods for identifying polypeptides and other compositions having such enhanced binding affinity are also described.Type: GrantFiled: June 3, 1993Date of Patent: August 5, 1997Assignee: The Regents of the University of CaliforniaInventors: Alan Frankel, Ruoying Tan, Derek Hudson
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Patent number: 5652122Abstract: This invention relates to delivery of biologically active cargo molecules, such as polypeptides and nucleic acids, into the cytoplasm and nuclei of cells in vitro and in vivo. Intracellular delivery of cargo molecules according to this invention is accomplished by the use of novel transport polypeptides which comprise HIV tat protein or one or more portions thereof, and which are covalently attached to cargo molecules. The transport polypeptides in preferred embodiments of this invention are characterized by the presence of the tat basic region (amino acids 49-57), the absence of the tat cysteine-rich region (amino acids 22-36) and the absence of the tat exon 2-encoded carboxy-terminal domain (amino acids 73-86) of the naturally-occurring tat protein. By virtue of the absence of the cysteine-rich region, the preferred transport polypeptides of this invention solve the potential problems of spurious trans-activation and disulfide aggregation.Type: GrantFiled: May 25, 1995Date of Patent: July 29, 1997Inventors: Alan Frankel, Carl Pabo, James G. Barsoum, Stephen E. Fawell, R. Blake Pepinsky